Abstract: The present disclosure is directed to methods and systems for detecting a chemical substance. The methods and systems include chemically modifying a sample of a substance of interest through combination with a reagent to increase the volatility of the substance of interest. The systems and methods further include performing an analysis of the substance of interest.

Abstract: A method is provided for reducing the severity and/or frequency of symptoms or clinical manifestations resulting from gluten ingestion by administering to a seropositive patient with symptomatic celiac disease, gluten intolerance, or gluten sensitivity latiglutenase (ALV003) in an amount from about 100 mg to about 1200 mg per day.

Abstract: The present disclosure is directed to methods and systems for detecting a chemical substance. The methods and systems include chemically modifying a sample of a substance of interest through combination with a reagent to increase the volatility of the substance of interest. The systems and methods further include performing an analysis of the substance of interest.

Abstract: The present disclosure is directed to methods and systems for detecting a chemical substance. The methods and systems include chemically modifying a sample of a substance of interest through combination with a reagent to increase the volatility of the substance of interest. The systems and methods further include performing an analysis of the substance of interest.

Abstract: The present disclosure is directed to methods and systems for detecting a chemical substance. The methods and systems include chemically modifying a sample of a substance of interest through combination with a reagent to increase the volatility of the substance of interest. The systems and methods further include performing an analysis of the substance of interest.

Abstract: A mass spectrometer system includes a sample injection device defining a sample injection aperture. The system also includes an ion trap defining an ion outlet aperture. The ion trap is coupled to the sample injection device. The system further includes a detector positioned downstream of the ion outlet aperture. The system also includes an ion source coupled to the ion trap. The ion source is configured to ionize a sample injected into the ion trap and generate a plurality of ionized molecules within the ion trap. The ion trap is configured to maintain the plurality of ionized molecules therein while a plurality of neutral molecules migrate out of the ion trap until a predetermined pressure is attained in the ion trap.

Abstract: A dual source ionizer includes a first ionization source and a second ionization source. The first ionization source is configured to generate a first electric field. The first electric field has a first field strength that is insufficient to form NOx? ions. The second ionization source is configured to generate a second electric field. The second electric field has a second field strength that is sufficient to form ozone and the NOx? ions.

Abstract: A dual source ionizer includes a first ionization source and a second ionization source. The first ionization source is configured to generate a first electric field. The first electric field has a first field strength that is insufficient to form NOx? ions. The second ionization source is configured to generate a second electric field. The second electric field has a second field strength that is sufficient to form ozone and the NOx? ions.

Abstract: The present disclosure is directed to methods and systems for detecting a chemical substance. The methods and systems include chemically modifying a sample of a substance of interest through combination with a reagent to increase the volatility of the substance of interest. The systems and methods further include performing an analysis of the substance of interest.

Abstract: The present disclosure is directed to methods and systems for detecting a chemical substance. The methods and systems include chemically modifying a sample of a substance of interest through combination with a reagent to increase the volatility of the substance of interest. The systems and methods further include performing an analysis of the substance of interest.

Abstract: The present disclosure is directed to methods and systems for detecting a chemical substance. The methods and systems include mixing a sample of a substance of interest with an additive and then producing an adduct using an ionization source. The systems and methods further include performing a spectrometric analysis of the adduct and identifying the sample using comparative spectrometric data.

Abstract: A dual source ionizer includes a first ionization source and a second ionization source. The first ionization source is configured to generate a first electric field. The first electric field has a first field strength that is insufficient to form NOx? ions. The second ionization source is configured to generate a second electric field. The second electric field has a second field strength that is sufficient to form ozone and the NOx? ions.

Abstract: The present disclosure is directed to methods and systems for detecting a chemical substance. The methods and systems include chemically modifying a sample of a substance of interest through combination with a reagent to increase the volatility of the substance of interest. The systems and methods further include performing an analysis of the substance of interest.

Abstract: The present disclosure is directed to methods and systems for detecting a chemical substance. The methods and systems include chemically modifying a sample of a substance of interest through combination with a reagent to increase the volatility of the substance of interest. The systems and methods further include performing an analysis of the substance of interest.

Abstract: A mass spectrometer system includes a sample injection device defining a sample injection aperture. The system also includes an ion trap defining an ion outlet aperture. The ion trap is coupled to the sample injection device. The system further includes a detector positioned downstream of the ion outlet aperture. The system also includes an ion source coupled to the ion trap. The ion source is configured to ionize a sample injected into the ion trap and generate a plurality of ionized molecules within the ion trap. The ion trap is configured to maintain the plurality of ionized molecules therein while a plurality of neutral molecules migrate out of the ion trap until a predetermined pressure is attained in the ion trap.

Abstract: A mass spectrometer system includes a pulsed ion source configured to generate ionized molecules and neutral molecules. The system also includes a first enclosure coupled in flow communication with the pulsed ion source. The first enclosure defines a first vacuum chamber and an ion inlet aperture. The system further includes a detector positioned within said first enclosure and a plurality of ion transmission devices positioned within the first vacuum chamber and aligned with the ion inlet aperture. The plurality of ion transmission devices is configured to channel and accelerate ionized molecules through a first transmission path such that the ionized molecules and the neutral molecules are physically separated in space and temporally separated.

Abstract: A method for detecting a chemical substance includes collecting a sample of a substance of interest and mixing the sample and at least one additive within a reaction chamber. The at least one additive includes a plurality of isotopes. The method also includes producing a plurality of adduct ions of the sample. The plurality of adduct ions has a plurality of isotopes. The method further includes performing a spectrometric analysis of the plurality of adduct ions and performing sample identification using comparative spectrometric data of the isotopes of the plurality of adduct ions.

Abstract: The present disclosure is directed to methods and systems for detecting a chemical substance. The methods and systems include mixing a sample of a substance of interest with an additive and then producing an adduct using an ionization source. The systems and methods further include performing a spectrometric analysis of the adduct and identifying the sample using comparative spectrometric data.

Abstract: A dual source ionizer includes a first ionization source and a second ionization source. The first ionization source is configured to generate a first electric field. The first electric field has a first field strength that is insufficient to form NOx? ions. The second ionization source is configured to generate a second electric field. The second electric field has a second field strength that is sufficient to form ozone and the NOx? ions.

Abstract: A mass spectrometer system includes a pulsed ion source configured to generate ionized molecules and neutral molecules. The system also includes a first enclosure coupled in flow communication with the pulsed ion source. The first enclosure defines a first vacuum chamber and an ion inlet aperture. The system further includes a detector positioned within said first enclosure and a plurality of ion transmission devices positioned within the first vacuum chamber and aligned with the ion inlet aperture. The plurality of ion transmission devices is configured to channel and accelerate ionized molecules through a first transmission path such that the ionized molecules and the neutral molecules are physically separated in space and temporally separated.