Patents by Inventor Jack D. Barchas
Jack D. Barchas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7049102Abstract: This invention relates to the use of promoters for ribonucleic acid amplification and other genetic manipulations. Processes are provided wherein complementary deoxyribonucleic acid (cDNA) is synthesized from a ribonucleic acid (RNA) sequence using a complementary primer linked to an RNA polymerase promoter region complement and then anti-sense RNA (aRNA) is transcribed from the cDNA by introducing an RNA polymerase capable of binding to the promoter region. Additional processes using the resulting aRNA are also described.Type: GrantFiled: November 15, 2000Date of Patent: May 23, 2006Assignee: Board of Trustees of Leland Stanford UniversityInventors: Russell N. Van Gelder, Mark E. Von Zastrow, Jack D. Barchas, James H. Eberwine
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Patent number: 6291170Abstract: This invention relates to the use of promoters for ribonucleic acid amplification and other genetic manipulations. Processes are provided wherein complementary deoxyribonucleic acid (cDNA) is synthesized from a ribonucleic acid (RNA) sequence using a complementary primer linked to an RNA polymerase promoter region complement and then anti-sense RNA (aRNA) is transcribed from the cDNA by introducing an RNA polymerase capable of binding to the promoter region. Additional processes using the resulting aRNA are also described.Type: GrantFiled: April 5, 1999Date of Patent: September 18, 2001Assignee: Board of Trustees of Leland Stanford UniversityInventors: Russell N. Van Gelder, Mark E. Von Zastrow, Jack D. Barchas, James D. Eberwine
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Patent number: 5891636Abstract: This invention relates to the use of promoters for ribonucleic acid amplification and other genetic manipulations. Processes are provided wherein complementary deoxyribonucleic acid (cDNA) is synthesized from a ribonucleic acid (RNA) sequence using a complementary primer linked to an RNA polymerase promoter region complement and then anti-sense RNA (aRNA) is transcribed from the cDNA by introducing an RNA polymerase capable of binding to the promoter region. Additional processes using the resulting aRNA are also described.Type: GrantFiled: September 3, 1997Date of Patent: April 6, 1999Assignee: Board of Trustees of Leland Stanford UniversityInventors: Russell N. Van Gelder, Mark E. Von Zastrow, Jack D. Barchas, James H. Eberwine
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Patent number: 5716785Abstract: This invention relates to the use of promoters for ribonucleic acid amplification and other genetic manipulations. Processes are provided wherein complementary deoxyribonucleic acid (cDNA) is synthesized from a ribonucleic acid (RNA) sequence using a complementary primer linked to an RNA polymerase promoter region complement and then anti-sense RNA (aRNA) is transcribed from the cDNA by introducing an RNA polymerase capable of binding to the promoter region. Additional processes using the resulting aRNA are also described.Type: GrantFiled: April 19, 1996Date of Patent: February 10, 1998Assignee: Board of Trustees of Leland Stanford Junior UniversityInventors: Russell N. Van Gelder, Mark E. Von Zastrow, Jack D. Barchas, James H. Eberwine
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Patent number: 5545522Abstract: This invention relates to the use of promoters for ribonucleic acid amplification and other genetic manipulations. Processes are provided wherein complementary deoxyribonucleic acid (cDNA) is synthesized from a ribonucleic acid (RNA) sequence using a complementary primer linked to an RNA polymerase promoter region complement and then anti-sense RNA (aRNA) is transcribed from the cDNA by introducing an RNA polymerase capable of binding to the promoter region. Additional processes using the resulting aRNA are also described.Type: GrantFiled: October 5, 1992Date of Patent: August 13, 1996Inventors: Russell N. Van Gelder, Mark E. Von Zastrow, Jack D. Barchas, James H. Eberwine
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Patent number: 5169852Abstract: Compounds of formula I are useful for suppressing appetite, and for altering macronutrient preferences, ##STR1## where the R.sub.2 -R.sub.9 substituents are so selected as to meet a defined quantitative structure activity relationship (QSAR) quantity relating to the partition coefficient of the compound, the net charge on the ring nitrogen, and the radical superfdelocalizability at the position-8 ring carbon.Type: GrantFiled: December 14, 1990Date of Patent: December 8, 1992Assignee: Neurex CorporationInventors: Jack D. Barchas, Glen R. Elliott, Peter I. Adriaenssens, Robert S. Bitner, Stephen S. Bowersox
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Patent number: 5168038Abstract: In situ transcription is provided by hybridizing cells or tissue with a primer, and extending the primer bound to any template mRNA or DNA with transverse transcriptase or DNA polymerase in the presence of labeled nucleotides, which allows for detection of cells containing the template. The resulting cDNA may be eluted and used in a polymerase chain reaction for isolation of the DNA, and/or the cDNA electrophoresed, which may provide for information concerning the sequence, or the like.Type: GrantFiled: March 18, 1991Date of Patent: December 1, 1992Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Laurence Tecott, Jack D. Barchas, James Eberwine
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Patent number: 5021335Abstract: In situ transcription is provided by hybridizing cells or tissue with a primer, and extending the primer bound to any template mRNA or DNA with reverse transcriptase or DNA polymerase in the presence of labeled nucleotides, which allows for detection of cells containing the template. The resulting cDNA may be eluted and used in a polymerase chain reaction for isolation of the DNA, and/or the cDNA electrophoresed, which may provide for information concerning the sequence, or the like.Type: GrantFiled: June 17, 1988Date of Patent: June 4, 1991Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Laurence Tecott, Jack D. Barchas, James Eberwine
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Patent number: 4978669Abstract: Compounds of formula I are useful for suppressing appetite, for altering macronutrient preferences, for suppressing obsessive-compulsive behavior, and for inhibiting cravings and substance abuse: ##STR1## wherein R.sub.1 and R.sub.3 are each independently H, hydroxy-alkyl, alpha-cyanoalkyl, SO.sub.3 H, SO.sub.2 NH.sub.2, or C(O)R, where R is OH, NH.sub.2, lower alkoxy, benzyloxy, or aliphatic amino acyl;R.sub.2 and R.sub.9 are each independently H, lower alkyl, benzyl, succinyl, or C(O)R.sub.4, where R.sub.4 is H, lower alkyl, hydrocarboxy-lower alkylene, or lower alkoxycarboxy-lower alkylene; andR.sub.5, R.sub.6, R.sub.7, and R.sub.8 are each independently H, halo, lower alkyl, hydroxy, lower alkoxy, or two adjacent radicals form methylenedioxy or ethylenedioxy;with the proviso that R.sub.1, R.sub.2, R.sub.3, R.sub.5, R.sub.6, R.sub.7, R.sub.8, and R.sub.9 are not simultaneously H.Type: GrantFiled: June 8, 1989Date of Patent: December 18, 1990Assignee: Neurex CorporationInventors: Jack D. Barchas, Glen R. Elliott, Peter I. Adriaenssens, Robert S. Bitner, Stephen S. Bowersox, Laszlo Nadasdi
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Patent number: 4613586Abstract: Novel peptides having gastrin releasing peptide-like activity having the structures Ala-Pro-Val-Ser-Val-Gly-Gly-Gly-Thr-Val-Leu-Ala-Lys-Met-Tyr-Pro-NH.sub.2 and Gly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met-NH.sub.2, have been isolated from rat and guinea pig brain extracts and synthesized by a solid phase peptide synthesis methods. The GRP-like peptides are useful as pharmaceuticals to lower body temperature, increase respiratory activity, reduce food intake, stimulate pancreatic hormone release, stimulate pituitary hormone release and suppress thyroid hormone release in mammals.Type: GrantFiled: April 19, 1984Date of Patent: September 23, 1986Assignee: Board of Trustees of the Leland Stanford Junior UniversityInventors: Jack D. Barchas, Eckard Weber, Christopher J. Evans, Jaw-Kang Chang, Robin G. Lorenz, Kevin A. Roth
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Patent number: 4587233Abstract: A method is provided for elevating blood pressure in mammals comprising the step of administering a polypeptide containing the C-terminal residue L-Arg-L-Phe or C-terminal esters or amides thereof.Type: GrantFiled: November 7, 1983Date of Patent: May 6, 1986Assignee: Board of Trustees of the Leland Stanford Junior UniversityInventors: Jack D. Barchas, Eckard Weber, Christopher J. Evans, E. T. Wei, J. K. Chang, Ingbert Fuchs, Gabriele Mues
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Patent number: 4490363Abstract: A morphine-like amidated opioid octapeptide metorphamide having the struce Try-Gly-Gly-Phe-Met-Arg-Arg-Val-NH.sub.2 has been isolated from bovine caudate nucleus extracts and synthesized by solid phase peptide synthesis methods. Metorphamide is thus far the only natural opioid peptide having a high .mu.-binding activity.Type: GrantFiled: June 24, 1983Date of Patent: December 25, 1984Assignee: Board of Trustees of The Leland Stanford Junior University Stanford Univ.Inventors: Jack D. Barchas, Eckard Weber, Christopher J. Evans