Patents by Inventor Jack HEATH

Jack HEATH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRISPR/RNA-guided nuclease systems and methods
    Patent number: 11963982
    Abstract: Genome editing systems, guide RNAs, dead guide RNAs, and CRISPR-mediated methods are provided for altering portions of a target nucleic acid.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: April 23, 2024
    Assignee: EDITAS MEDICINE, INC.
    Inventors: Edouard Aupepin De Lamothe-Dreuzy, Jack Heath, Jennifer Leah Gori, Luis Barrera
  • GENOME EDITING COMPOSITIONS AND METHODS FOR TREATMENT OF CHRONIC GRANULOMATOUS DISEASE
    Publication number: 20240011007
    Abstract: Provided herein are compositions and methods of using prime editing systems comprising prime editors and prime editing guide RNAs for treatment of genetic disorders.
    Type: Application
    Filed: August 14, 2023
    Publication date: January 11, 2024
    Inventors: Jennifer Gori, David Waterman, Jack Heath, Andrew V. Anzalone
  • Systems and methods for the treatment of hemoglobinopathies
    Patent number: 11851690
    Abstract: Genome editing systems, guide RNAs, and CRISPR-mediated methods are provided for altering portions of the HBG1 and HBG2 loci, portions of the erythroid specific enhancer of the BCL11A gene, or a combination thereof, in cells and increasing expression of fetal hemoglobin.
    Type: Grant
    Filed: September 12, 2019
    Date of Patent: December 26, 2023
    Assignee: EDITAS MEDICINE, INC.
    Inventors: Jennifer Leah Gori, Luis A. Barrera, Edouard Aupepin De Lamothe-Dreuzy, Jack Heath
  • SYSTEMS AND METHODS FOR THE TREATMENT OF HEMOGLOBINOPATHIES
    Publication number: 20220073951
    Abstract: Genome editing systems, guide RNAs, and CRISPR-mediated methods are provided for altering portions of the HBG1 and HBG2 loci in cells and increasing expression of fetal hemoglobin.
    Type: Application
    Filed: September 11, 2020
    Publication date: March 10, 2022
    Inventors: Jennifer Leah GORI, Edouard AUPEPIN DE LAMOTHE-DREUZY, Jack HEATH
  • SYSTEMS AND METHODS FOR THE TREATMENT OF HEMOGLOBINOPATHIES
    Publication number: 20220047637
    Abstract: Genome editing systems, guide RNAs, and CRISPR-mediated methods are provided for altering portions of the HBG1 and HBG2 loci, portions of the erythroid specific enhancer of the BCL11A gene, or a combination thereof, in cells and increasing expression of fetal hemoglobin.
    Type: Application
    Filed: November 27, 2019
    Publication date: February 17, 2022
    Applicant: EDITAS MEDICINE, INC.
    Inventors: Edouard AUPEPIN DE LAMOTHE-DREUZY, KaiHsin CHANG, Jack HEATH
  • SYSTEMS AND METHODS FOR THE TREATMENT OF HEMOGLOBINOPATHIES
    Publication number: 20220025363
    Abstract: Genome editing systems, guide RNAs, and CRISPR-mediated methods are provided for altering portions of the HBG1 and HBG2 loci, portions of the erythroid specific enhancer of the BCL11A gene, or a combination thereof, in cells and increasing expression of fetal hemoglobin.
    Type: Application
    Filed: December 8, 2020
    Publication date: January 27, 2022
    Applicant: EDITAS MEDICINE, INC.
    Inventors: Jennifier Leah GORI, Edouard AUPEPIN DE LAMOTHE-DREUZY, Jack HEATH, John Anthony ZURIS, KaiHsin CHANG
  • SYSTEMS AND METHODS FOR THE TREATMENT OF HEMOGLOBINOPATHIES
    Publication number: 20210254061
    Abstract: Genome editing systems, guide RNAs, and CRISPR-mediated methods are provided for altering portions of the HBG1 and HBG2 loci, portions of the erythroid specific enhancer of the BCL11A gene, or a combination thereof, in cells and increasing expression of fetal hemoglobin.
    Type: Application
    Filed: September 11, 2020
    Publication date: August 19, 2021
    Inventors: Jennifer Leah GORI, Edouard AUPEPIN DE LAMOTHE-DREUZY, Jack HEATH, John Anthony ZURIS, KaiHsin CHANG
  • SYSTEMS AND METHODS FOR THE TREATMENT OF HEMOGLOBINOPATHIES
    Publication number: 20210230638
    Abstract: Genome editing systems, guide RNAs, and CRISPR-mediated methods are provided for altering portions of the HBG1 and HBG2 loci in cells and increasing expression of fetal hemoglobin.
    Type: Application
    Filed: September 4, 2020
    Publication date: July 29, 2021
    Applicant: EDITAS MEDICINE, INC.
    Inventors: Edouard AUPEPIN DE LAMOTHE-DREUZY, KaiHsin CHANG, Minerva Elaine SANCHEZ, Jack HEATH
  • Tubular wellhead assembly
    Patent number: 10890044
    Abstract: A wellhead assembly of a well system for installation in a wellbore, the wellhead assembly having a longitudinal axis and including a wellhead housing including a central passage defined by an inner surface, a hanger configured to be received within the passage of the wellhead housing and couple to the inner surface of the housing, a tubular string configured to be received in the passage of the wellhead housing, wherein the tubular string includes a passage, a choke coupled to the tubular string and configured to control a fluid flow through the passage of the tubular string, and a wellhead connector configured to releasably couple to an end of the wellhead housing and including a first passage in fluid communication with passage of the tubular string when the wellhead connector is coupled to the wellhead housing.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: January 12, 2021
    Assignee: ONESUBSEA IP UK LIMITED
    Inventor: Jack Heath Vincent
  • SYSTEMS AND METHODS FOR THE TREATMENT OF HEMOGLOBINOPATHIES
    Publication number: 20200157515
    Abstract: Genome editing systems, guide RNAs, and CRISPR-mediated methods are provided for altering portions of the HBG1 and HBG2 loci, portions of the erythroid specific enhancer of the BCL11A gene, or a combination thereof, in cells and increasing expression of fetal hemoglobin.
    Type: Application
    Filed: September 12, 2019
    Publication date: May 21, 2020
    Inventors: Jennifer Leah GORI, Luis A. Barrera, Edouard Aupepin De Lamothe-Dreuzy, Jack Heath
  • CRISPR/RNA-GUIDED NUCLEASE SYSTEMS AND METHODS
    Publication number: 20200155606
    Abstract: Genome editing systems, guide RNAs, dead guide RNAs, and CRISPR-mediated methods are provided for altering portions of a target nucleic acid.
    Type: Application
    Filed: November 8, 2019
    Publication date: May 21, 2020
    Applicant: Editas Medicine, Inc.
    Inventors: Edouard AUPEPIN DE LAMOTHE-DREUZY, Jack HEATH, Jennifer LEAH GORI, Luis BARRERA
  • TUBULAR WELLHEAD ASSEMBLY
    Publication number: 20180119513
    Abstract: A wellhead assembly of a well system for installation in a wellbore, the wellhead assembly having a longitudinal axis and including a wellhead housing including a central passage defined by an inner surface, a hanger configured to be received within the passage of the wellhead housing and couple to the inner surface of the housing, a tubular string configured to be received in the passage of the wellhead housing, wherein the tubular string includes a passage, a choke coupled to the tubular string and configured to control a fluid flow through the passage of the tubular string, and a wellhead connector configured to releasably couple to an end of the wellhead housing and including a first passage in fluid communication with passage of the tubular string when the wellhead connector is coupled to the wellhead housing.
    Type: Application
    Filed: October 28, 2016
    Publication date: May 3, 2018
    Inventor: Jack Heath VINCENT