Patents by Inventor Jack Mathew Webster
Jack Mathew Webster has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220242923Abstract: Disclosed herein are compositions and methods directed to non-antibody protein scaffolds derived from cold-shock proteins.Type: ApplicationFiled: January 31, 2022Publication date: August 4, 2022Inventor: Jack Mathew WEBSTER
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Patent number: 9468693Abstract: Imaging agents are described that comprise labeled substrates capable of being introduced into cells via the cystine/glutamate antiporter. The substrates may be used for imaging or detecting oxidative stress in cells by introducing the labeled agents into cells via the cystine/glutamate antiporter and subsequent detection.Type: GrantFiled: January 23, 2014Date of Patent: October 18, 2016Assignee: General Electric CompanyInventors: Bruce Allan Hay, Jack Mathew Webster
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Patent number: 9468692Abstract: Imaging agents are described that comprise labeled substrates capable of being introduced into cells via the cystine/glutamate antiporter. The substrates may be used for imaging or detecting oxidative stress in cells by introducing the labeled agents into cells via the cystine/glutamate antiporter and subsequent detection.Type: GrantFiled: January 23, 2014Date of Patent: October 18, 2016Assignee: General Electric CompanyInventors: Bruce Allan Hay, Jack Mathew Webster
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Patent number: 9297770Abstract: A calorie estimating device for measuring a calorie content of a food item is provided. The device comprises a holder substrate, a transmitter antenna configured to transmit ultra-wide band (UWB) signals to at least a portion of the food item disposed on a side of the holder substrate, wherein the transmitter antenna comprises a planar antenna, a first receiver antenna configured to receive at least a portion of UWB signals reflected by the food item, wherein the first receiver antenna comprises a planar antenna, and a second receiver antenna configured to receive at least a portion of UWB signals propagated through the food item, wherein the second receiver antenna comprises a planar antenna.Type: GrantFiled: July 29, 2011Date of Patent: March 29, 2016Assignee: General Electric CompanyInventors: Nilesh Tralshawala, John Frederick Graf, Jack Mathew Webster, Vasile Bogdan Neculaes, Sarah Lillian Katz
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Patent number: 9244049Abstract: A system for measuring nutritional parameters of food items is provided. The system includes a holding cavity. The system further includes a sensor assembly that includes a transmitter antenna and at least one receiver antenna. The transmitter antenna is configured to transmit signals to a food item in the holding cavity. The receiver antenna is configured to receive response signals from the food item. The system includes at least one switch coupled to each antenna. The switch, in a first state, is configured to set the sensor assembly to an electric potential equal to that of the holding cavity. In a second state, the switch is configured to couple the sensor assembly to a power source. The system also includes a processing unit to process the signals received to determine the nutritional parameters of the food item.Type: GrantFiled: May 7, 2013Date of Patent: January 26, 2016Assignee: General Electric CompanyInventors: Yongjae Lee, Aghogho Atemu Obi, Seog Tae Kim, William Chester Platt, James William Bray, Yuri Alexeyevich Plotnikov, Jack Mathew Webster, Vasile Bogdan Neculaes
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Publication number: 20150202333Abstract: Imaging agents are described that comprise labeled substrates capable of being introduced into cells via the cystine/glutamate antiporter. The substrates may be used for imaging or detecting oxidative stress in cells by introducing the labeled agents into cells via the cystine/glutamate antiporter and subsequent detection.Type: ApplicationFiled: January 23, 2014Publication date: July 23, 2015Applicant: General Electric CompanyInventors: Bruce Allan Hay, Jack Mathew Webster
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Publication number: 20150202332Abstract: Imaging agents are described that comprise labeled substrates capable of being introduced into cells via the cystine/glutamate antiporter. The substrates may be used for imaging or detecting oxidative stress in cells by introducing the labeled agents into cells via the cystine/glutamate antiporter and subsequent detection.Type: ApplicationFiled: January 23, 2014Publication date: July 23, 2015Applicant: GENERAL ELECTRIC COMPANYInventors: Bruce Allan Hay, Jack Mathew Webster
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Publication number: 20140331796Abstract: A system for measuring nutritional parameters of food items is provided. The system includes a holding cavity. The system further includes a sensor assembly that includes a transmitter antenna and at least one receiver antenna. The transmitter antenna is configured to transmit signals to a food item in the holding cavity. The receiver antenna is configured to receive response signals from the food item. The system includes at least one switch coupled to each antenna. The switch, in a first state, is configured to set the sensor assembly to an electric potential equal to that of the holding cavity. In a second state, the switch is configured to couple the sensor assembly to a power source. The system also includes a processing unit to process the signals received to determine the nutritional parameters of the food item.Type: ApplicationFiled: May 7, 2013Publication date: November 13, 2014Applicant: General Electric CompanyInventors: Yongjae Lee, Aghogho Atemu Obi, Seog Tae Kim, William Chester Platt, James William Bray, Yuri Alexeyevich Plotnikov, Jack Mathew Webster, Vasile Bogdan Neculaes
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Patent number: 8834839Abstract: Imaging agents that comprise labeled substrates of the cystine/glutamate antiporter of cells, whereby the methods of use comprise introducing the labeled agents into cells via the cystine/glutamate antiporter, which are then reduced to a labeled cysteine, and subsequently detected in the cell.Type: GrantFiled: April 27, 2009Date of Patent: September 16, 2014Assignee: General Electric CompanyInventors: Paul Schaffer, Brian Duh-Lan Lee, Kande Kankanamalage Dayarathna Amarasinghe, Faisal Ahmed Syud, Rong Zhang, Jack Mathew Webster, Jennifer Lynne Huntington
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Patent number: 8784774Abstract: Imaging agents are described that comprise labeled substrates capable of being introduced into cells via the cystine/glutamate antiporter. The substrates may be used for imaging or detecting oxidative stress in cells by introducing the labeled agents into cells via the cystine/glutamate antiporter and subsequent detection.Type: GrantFiled: September 16, 2011Date of Patent: July 22, 2014Assignee: General Electric CompanyInventors: Jack Mathew Webster, Bruce Fletcher Johnson, Brian Duh-Lan Lee, Chittari Pabba, Michael James Rishel
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Publication number: 20130071332Abstract: Imaging agents are described that comprise labeled substrates capable of being introduced into cells via the cystine/glutamate antiporter. The substrates may be used for imaging or detecting oxidative stress in cells by introducing the labeled agents into cells via the cystine/glutamate antiporter and subsequent detection.Type: ApplicationFiled: September 16, 2011Publication date: March 21, 2013Applicant: GENERAL ELECTRIC COMPANYInventors: Jack Mathew Webster, Bruce Fletcher Johnson, Brian Duh-Lan Lee, Chittari Pabba, Michael James Rishel
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Publication number: 20130027060Abstract: A calorie estimating device for measuring a calorie content of a food item is provided. The device comprises a holder substrate, a transmitter antenna configured to transmit ultra-wide band (UWB) signals to at least a portion of the food item disposed on a side of the holder substrate, wherein the transmitter antenna comprises a planar antenna, a first receiver antenna configured to receive at least a portion of UWB signals reflected by the food item, wherein the first receiver antenna comprises a planar antenna, and a second receiver antenna configured to receive at least a portion of UWB signals propagated through the food item, wherein the second receiver antenna comprises a planar antenna.Type: ApplicationFiled: July 29, 2011Publication date: January 31, 2013Applicant: GENERAL ELECTRIC COMPANYInventors: Nilesh Tralshawala, John Frederick Graf, Jack Mathew Webster, Vasile Bogdan Neculaes, Sarah Lillian Katz
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Patent number: 8318456Abstract: Provided herein are isolated polypeptides derived from the staphylococcal protein A protein B domain comprising a pair of anti-parallel alpha helices that are capable of binding a target. Also provided are nucleic acid sequences encoding such two helix binders, vectors containing the nucleic acid sequences encoding for two helix binders, and host cells transformed with vectors containing the nucleic acid sequences encoding for the two-helix binders. Also provided are methods of using the two helix binders.Type: GrantFiled: May 23, 2012Date of Patent: November 27, 2012Assignee: General Electric CompanyInventors: Faisal Ahmed Syud, Jack Mathew Webster
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Publication number: 20120253006Abstract: Provided herein are isolated polypeptides derived from the staphylococcal protein A protein B domain comprising a pair of anti-parallel alpha helices that are capable of binding a target. Also provided are nucleic acid sequences encoding such two helix binders, vectors containing the nucleic acid sequences encoding for two helix binders, and host cells transformed with vectors containing the nucleic acid sequences encoding for the two-helix binders. Also provided are methods of using the two helix binders.Type: ApplicationFiled: May 23, 2012Publication date: October 4, 2012Applicant: General Electric CompanyInventors: Faisal Ahmed Syud, Jack Mathew Webster
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Patent number: 8198043Abstract: Provided herein are isolated polypeptides derived from the staphylococcal protein A protein B domain comprising a pair of anti-parallel alpha helices that are capable of binding a target. Also provided are nucleic acid sequences encoding such two helix binders, vectors containing the nucleic acid sequences encoding for two helix binders, and host cells transformed with vectors containing the nucleic acid sequences encoding for the two-helix binders. Also provided are methods of using the two helix binders.Type: GrantFiled: December 8, 2006Date of Patent: June 12, 2012Assignee: General Electric CompanyInventors: Faisal Ahmed Syud, Jack Mathew Webster
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Publication number: 20120053426Abstract: A system includes an estimating unit to non-destructively estimate a fat content and a water content of a food sample. The system further includes a processing unit operatively coupled to the estimating unit to determine a calorie content based solely on the fat content and the water content of the food sample.Type: ApplicationFiled: August 31, 2010Publication date: March 1, 2012Applicant: GENERAL ELECTRIC COMPANYInventors: Jack Mathew Webster, Vasile Bogdan Neculaes
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Patent number: 7989216Abstract: An isolated polypeptide, Z domain, derived from B domain of Staphylococcal protein A, comprising a pair of anti-parallel alpha helices that are capable of binding a target, is provided herein. Introduction of different natural amino acid mutations in the polypeptide are provided here. Also provided are methods of using the two-helix binders.Type: GrantFiled: December 18, 2008Date of Patent: August 2, 2011Assignee: General Electric CompanyInventors: Rong Zhang, Faisal Ahmed Syud, Jack Mathew Webster
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Patent number: 7981691Abstract: An isolated polypeptide, Z domain, derived from B domain of Staphylococcal protein A, comprising a pair of anti-parallel alpha helices that are capable of binding a target, is provided herein. Introduction of a covalent bridge between two modified amino acids in the polypeptide is provided here. Also provided are methods of using the two-helix binders.Type: GrantFiled: December 18, 2008Date of Patent: July 19, 2011Assignee: General Electric CompanyInventors: Joshua Kendall Hoerner, Rong Zhang, Faisal Ahmed Syud, Jack Mathew Webster
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Patent number: 7977118Abstract: An isolated polypeptide, Z domain, derived from B domain of Staphylococcal protein A, comprising a pair of anti-parallel alpha helices that are capable of binding a target, is provided herein. Introduction of an un-natural amino acid in the polypeptide is provided here. Also provided are methods of using the two-helix binders.Type: GrantFiled: December 18, 2008Date of Patent: July 12, 2011Assignee: General Electric CompanyInventors: Rong Zhang, Faisal Ahmed Syud, Jack Mathew Webster
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Publication number: 20100272641Abstract: Imaging agents that comprise labeled substrates of the cystine/glutamate antiporter of cells, whereby the methods of use comprise introducing the labeled agents into cells via the cystine/glutamate antiporter, which are then reduced to a labeled cysteine, and subsequently detected in the cell.Type: ApplicationFiled: April 27, 2009Publication date: October 28, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: JACK MATHEW WEBSTER, FAISAL AHMED SYUD, BRIAN DUH-LAN LEE, PAUL SCHAFFER, RONG ZHANG, JENNIFER LYNNE HUNTINGTON, KANDE KANKANAMALAGE DAYARATHNA AMARASINGHE