Abstract: Provided are methods for and compounds for modulating the complement system. In particular, compounds are provided that inhibit complement activation and compounds are provided that promote complement activation. The compounds are therapeutics by virtue of their effects on the complement system. Hence, the compounds that inhibit complement activation can be used for treatment of ischemic and reperfusion disorders, including myocardial infarction and stroke, sepsis, autoimmune diseases, inflammatory diseases and diseases with an inflammatory component, including Alzheimer's Disease and other neurodegenerative disorder.

Abstract: Disclosed herein are methods for creating and using mutein proteases with altered specificity for the target molecules they cleave. The invention further discloses methods of using wild-type and mutein granzyme B to target VEGFR proteins to treat diseases, such as cancer. Cleaving VEGFR at certain substrate sequences with wild-type and mutein granzyme B proteases is a method for treating pathologies associated with angiogenesis.

Abstract: MT-SP1 mutein proteases with altered specificity for the target molecules they cleave can be used to treat human diseases, such as cancer. Cleaving VEGF or VEGFR at certain substrate sequences with wild-type and mutein MT-SP1 proteases can be used to treat pathologies associated with angiogenesis.

Abstract: Disclosed herein are methods for generating proteases with altered specificity for the target molecules they cleave. The invention further discloses methods of using these proteases to treat diseases in which the target proteins are involved with. Cleaving certain target proteins at certain substrate sequences with a protease is a method for treating these pathologies.

Abstract: The present invention provides methods of identifying modulators of apoptosis.

Abstract: A cleaning dispenser assembly to be used in connection with a toilet tank is coupled to a fill valve and an overflow tube of the tank. The dispenser assembly includes a container with a removable lid. A refill tube is coupled to a fill valve of the tank and the container. Tall and short discharge tubes are coupled to the container at different heights to facilitate the withdrawal of fluid from the container while preventing a vacuum from developing within the closed container. U-traps are formed in the refill tube and the discharge tubes to retain a portion of liquid in a steady state so as to seal the passageways in order to prevent gases from escaping into the tank.

Abstract: A cleaning dispenser assembly to be used in connection with a toilet tank is coupled to a fill valve and an overflow tube of the tank. The dispenser assembly includes a container with a removable lid. A refill tube is coupled to a fill valve of the tank and the container. Tall and short discharge tubes are coupled to the container at different heights to facilitate the withdrawal of fluid from the container while preventing a vacuum from developing within the closed container. U-traps are formed in the refill tube and the discharge tubes to retain a portion of liquid in a steady state so as to seal the passageways in order to prevent gases from escaping into the tank.