Patents by Inventor Jack R. Wands

Jack R. Wands has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of Alzheimer's Disease
    Patent number: 7226730
    Abstract: Disclosed are transgenic animals and transfected cell lines expressing a protein associated with Alzheimer's Disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. Also disclosed is the use of such transgenic animals and transfected cell lines to screen potential drug candidates for treating or preventing Alzheimer's disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. The invention also relates to new antisense oligonucleotides, ribozymes, triplex forming DNA and external guide sequences that can be used to treat or prevent Alzheimer's disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas.
    Type: Grant
    Filed: February 26, 1998
    Date of Patent: June 5, 2007
    Assignee: The General Hospital Corporation
    Inventors: Suzanne De La Monte, Jack R. Wands
  • Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of Alzheimer's disease
    Patent number: 7138380
    Abstract: Disclosed are transgenic animals and transfected cell lines expressing a protein associated with Alzheimer's Disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. Also disclosed is the use of such transgenic animals and transfected cell lines to screen potential drug candidates for treating or preventing Alzheimer's disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. The invention also relates to new antisense oligonucleotides, ribozymes, triplex forming DNA and external guide sequences that can be used to treat or prevent Alzheimer's disease, neuroectodermnal tumors, malignant astrocytomas, and glioblastomas.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: November 21, 2006
    Assignee: The General Hospital Corporation
    Inventors: Suzanne De La Monte, Jack R Wands
  • Methods of inhibiting metastases
    Patent number: 7122541
    Abstract: The invention relates to methods for preventing and treating disseminating cancers. Inhibition metastases of a primary tumor to a liver tissue is carried out by directly contacting a liver tissue with Taurolidine.
    Type: Grant
    Filed: June 21, 2004
    Date of Patent: October 17, 2006
    Assignee: Rhode Island Hospital
    Inventors: Jack R. Wands, Rolf I. Carlson, Paul Maggio
  • Diagnosis and treatment of malignant neoplasms
    Patent number: 7094556
    Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: August 22, 2006
    Assignee: Rhode Island Hospital
    Inventors: Jack R. Wands, Suzanne M de la Monte, Nedim Ince, Rolf I. Carlson
  • Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of Alzheimer's disease
    Patent number: 7045616
    Abstract: Disclosed are transgenic animals and transfected cell lines expressing a protein associated with Alzheimer's Disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. Also disclosed is the use of such transgenic animals and transfected cell lines to screen potential drug candidates for treating or preventing Alzheimer's disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. The invention also relates to new antisense oligonucleotides, ribozymes, triplex forming DNA and external guide sequences that can be used to treat or prevent Alzheimer's disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: May 16, 2006
    Assignee: The General Hospital Corporation
    Inventors: Suzanne de la Monte, Jack R Wands
  • Diagnosis and treatment of malignant neoplasms
    Patent number: 6835370
    Abstract: The invention features a method for diagnosing and inhibiting growth of a malignant neoplasm in a mammal by contacting a cell or a bodily fluid of the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide. Methods of immunization to generate an HAAH-specific immune response are also within the invention.
    Type: Grant
    Filed: May 17, 2001
    Date of Patent: December 28, 2004
    Assignee: Rhode Island Hospital
    Inventors: Jack R. Wands, Suzanne M. de la Monte, Alan H. Deutch, Hossein A. Ghanbari
  • Diagnosis and treatment of malignant neoplasms
    Patent number: 6815415
    Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: November 9, 2004
    Assignee: Rhode Island Hospital
    Inventors: Jack R. Wands, Suzanne M. de la Monte, Nedim Ince, Rolf I. Carlson
  • Diagnosis and treatment of malignant neoplasms
    Patent number: 6812206
    Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: November 2, 2004
    Assignee: Rhode Island Hospital
    Inventors: Jack R. Wands, Suzanne M. de la Monte, Nedim Ince, Rolf I. Carlson
  • Diagnosis and treatment of malignant neoplasms
    Patent number: 6797696
    Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: September 28, 2004
    Assignee: Rhode Island Hospital
    Inventors: Jack R. Wands, Suzanne M. de la Monte, Nedim Ince, Rolf I. Carlson
  • Diagnosis and treatment of malignant neoplasms
    Patent number: 6783758
    Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: August 31, 2004
    Assignee: Rhode Island Hospital
    Inventors: Jack R. Wands, Suzanne M. de la Monte, Nedim Ince, Rolf I. Carlson
  • Non-Transgenic nonhuman model for Alzheimer's Disease using a AD7c-NTP nucleic acid
    Patent number: 6770797
    Abstract: The invention features a non-transgenic model of Alzheimer's Disease, method for inducing prolonged in vivo gene expression in a mammal, and methods of inhibiting Alzheimer's Disease-associated neuronal cell death.
    Type: Grant
    Filed: June 1, 2001
    Date of Patent: August 3, 2004
    Assignee: Rhode Island Hospital
    Inventors: Jack R. Wands, Suzanne M. de la Monte
  • Methods of inhibiting metastases
    Patent number: 6753328
    Abstract: The invention relates to methods for preventing and treating disseminating cancers. Inhibition metastases of a primary tumor to a liver tissue is carried out by directly contacting a liver tissue with Taurolidine.
    Type: Grant
    Filed: October 1, 2002
    Date of Patent: June 22, 2004
    Assignee: Rhode Island Hospital
    Inventors: Jack R. Wands, Rolf I. Carlson, Paul Maggio
  • Method for treating or preventing Alzheimer's disease
    Publication number: 20040060077
    Abstract: Disclosed is a method for treating or preventing Alzheimer's disease by restricting the level of metabolizable carbohydrate in the diet and/or administering to the patient an effective amount of an agent which reduces serum insulin levels.
    Type: Application
    Filed: September 23, 2003
    Publication date: March 25, 2004
    Inventors: Robert W. Esmond, Jack R. Wands, Suzanne de la Monte
  • Method for treating or preventing Alzheimer's disease
    Publication number: 20040058873
    Abstract: Disclosed is a method for treating or preventing Alzheimer's disease by restricting the level of metabolizable carbohydrate in the diet and/or administering to the patient an effective amount of an agent which reduces serum insulin levels.
    Type: Application
    Filed: September 23, 2003
    Publication date: March 25, 2004
    Inventors: Robert W. Esmond, Jack R. Wands, Suzanne de la Monte
  • Methods of inhibiting metastases
    Publication number: 20030069229
    Abstract: The invention relates to methods for preventing and treating disseminating cancers. Inhibition metastases of a primary tumor to a liver tissue is carried out by directly contacting a liver tissue with Taurolidine.
    Type: Application
    Filed: October 1, 2002
    Publication date: April 10, 2003
    Inventors: Jack R. Wands, Rolf I. Carlson, Paul Maggio
  • Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of Alzheimer's Disease
    Publication number: 20030066097
    Abstract: Disclosed are transgenic animals and transfected cell lines expressing a protein associated with Alzheimer's Disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. Also disclosed is the use of such transgenic animals and transfected cell lines to screen potential drug candidates for treating or preventing Alzheimer's disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. The invention also relates to new antisense oligonucleotides, ribozymes, triplex forming DNA and external guide sequences that can be used to treat or prevent Alzheimer's disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas.
    Type: Application
    Filed: September 28, 2001
    Publication date: April 3, 2003
    Inventors: Suzanne De La Monte, Jack R. Wands
  • Inhibition of neurodegeneration
    Publication number: 20030050262
    Abstract: The invention features a non-transgenic model of Alzheimer's Disease, method for inducing prolonged in vivo gene expression in a mammal, and methods of inhibiting Alzheimer's Disease-associated neuronal cell death.
    Type: Application
    Filed: June 1, 2001
    Publication date: March 13, 2003
    Inventors: Jack R. Wands, Suzanne M. de la Monte
  • Dominant negative mutants of IRS-1 and uses thereof
    Patent number: 6528479
    Abstract: Dominant negative mutants of mammalian IRS-1 proteins and therapeutic compositions containing such mutants. Also featured are methods of using the dominant negative mutants to inhibit tyrosyl phosphorylation of endogenous IRS-1 in mammalian cells and methods of treating a mammalian malignancy in which tyrosyl phosphorylation of endogenous IRS-1 plays a causative role.
    Type: Grant
    Filed: November 4, 1997
    Date of Patent: March 4, 2003
    Assignee: The General Hospital Corporation
    Inventors: Shinji Tanaka, Jack R. Wands
  • DIAGNOSIS AND TREATMENT OF MALIGNANT NEOPLASMS
    Publication number: 20030031670
    Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
    Type: Application
    Filed: November 8, 1999
    Publication date: February 13, 2003
    Inventors: JACK R. WANDS, SUZANNE M. DE LA MONTE, NEDIM INCE, ROLF I. CARLSON
  • Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of Alzheimer's disease
    Publication number: 20030033621
    Abstract: Disclosed are transgenic animals and transfected cell lines expressing a protein associated with Alzheimer's Disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. Also disclosed is the use of such transgenic animals and transfected cell lines to screen potential drug candidates for treating or preventing Alzheimer's disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. The invention also relates to new antisense oligonucleotides, ribozymes, triplex forming DNA and external guide sequences that can be used to treat or prevent Alzheimer's disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas.
    Type: Application
    Filed: September 28, 2001
    Publication date: February 13, 2003
    Inventors: Suzanne De La Monte, Jack R. Wands