Patents by Inventor Jack Silver
Jack Silver has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5104865Abstract: Compounds in which two or more rings, being a 3-hydroxpypyrid-2-one, 3-hydroxypyrid-4-one or 1-hydroxpyrid-2-one, are linked are of value in the treatment of patients having a toxic concentration of a metal, particularly iron, in the body while the iron complexes of such compounds are of value in the treatment of iron deficiency anaemia.Type: GrantFiled: September 1, 1989Date of Patent: April 14, 1992Assignee: National Research Development CorporationInventors: Robert C. Hider, George Kontoghiorghes, Jack Silver, Michael A. Stockham
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Patent number: 4912118Abstract: Compounds in which two or more rings, being a 3-hydroxpypyrid-2-one, 3-hydroypyrid-4-one or 1-hydropyrid-2-one, are linked are of value in the treatment of patients having a toxic concentration of a metal, particularly iron, in the body while the iron complexes of such compounds are of value in the treatment of iron deficienType: GrantFiled: December 22, 1986Date of Patent: March 27, 1990Assignee: National Research Development CorporationInventors: Robert C. Hider, George Kontoghiorghes, Jack Silver, Michael A. Stockham
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Patent number: 4894455Abstract: Zinc(II) complexes in which at least one ligand is provided by a compound being:(1) 3-hydroxy-4-pyrone or a 3-hydroxy-4-pyrone in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by an aliphatic hydrocarbon group of 1 to 6 carbon atoms; or(2) a 3-hydroxypyrid-2-one or 3-hydroxypyrid-4-one in which the hydrogen atom attached to the nitrogen atom is replaced by an aliphatic acyl group, by an aliphatic hydrocarbon group of 1 to 6 carbon atoms, or by an aliphatic hydrocarbon group substituted by one or, except in the case of ionizable groups, more than one substituent selected from aliphatic acyl, alkoxy, aliphatic amine, aliphatic amide, carboxy, aliphatic ester, halogen, hydroxy and sulpho groups and, optionally, in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by one of said substituents, by an aliphatic hydrocarbon group of 1 to 6 carbon atoms, or by an aliphatic hydrocarbon group substituted by an alkoxy, aliphatic ester, halogen or hydroType: GrantFiled: February 18, 1987Date of Patent: January 16, 1990Assignee: National Research Development CorporationInventors: Robert C. Hider, George Kontoghiorghes, Jack Silver, Michael A. Stockham
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Patent number: 4840958Abstract: Pharmaceutical compositions containing a 3-hydroxyprid-2-one or 3-hydroxypyrid-4-one in which the hydrogen atom attached to the nitrogen atom is replaced by an aliphatic hydrocarbon group of 1 to 6 carbon atoms and, optionally, in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by an aliphatic hydrocarbon group of 1 to 6 carbon atoms, or a salt thereof containing a physiologically acceptable cation, are of value for removing toxic amounts of metals, particularly iron, from the body. These compositions are useful in the treatment of iron overloads.Type: GrantFiled: November 20, 1986Date of Patent: June 20, 1989Assignee: National Research Development CorporationInventors: Robert C. Hider, George Kontoghiorghes, Jack Silver
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Patent number: 4775227Abstract: An electrochromic device consists of the layers: tin-oxide-coated glass; rare earth diphthalocyanine (REDPC); membrane electrolyte; REDPC; tin-oxide-coated glass. The REDPC is the electrochromic layer and contains a mixture of rare earths as obtained from a natural deposit without being individually separated. The REDPC is preheated to purify it and then sublimed into position as the device is assembled.The device is driven by a controller which is limited to the voltage range +2V to -1V, whereby only the colors red, green and blue are obtainable, that is, although the REDPC at -1.5V would show purple, this is deliberately foregone to prolong its life.The REDPC may be further mixed with tin phthalocyanine chloride or ruthenium, iron, zinc or cobalt phthalocyanine.Type: GrantFiled: June 3, 1986Date of Patent: October 4, 1988Assignee: National Research Development CorporationInventor: Jack Silver
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Patent number: 4666927Abstract: Compounds in which two or more rings, being a 3-hydroxypypyrid-2-one, 3-hydroxypyrid-4-one or 1-hydroxpyrid-2-one, are linked are of value in the treatment of patients having a toxic concentration of a metal, particularly iron, in the body while the iron complexes of such compounds are of value in the treatment of iron deficiency anaemia.Type: GrantFiled: September 18, 1984Date of Patent: May 19, 1987Assignee: National Research Development CorporationInventors: Robert C. Hider, George Kontoghiorghes, Jack Silver, Michael A. Stockham
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Patent number: 4665064Abstract: Zinc(II) complexes in which at least one ligand is provided by a compound being:(1) 3-hydroxy-4-pyrone or a 3-hydroxy-4-pyrone in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by an aliphatic hydrocarbon group of 1 to 6 carbon atoms; or(2) a 3-hydroxypyrid-2-one or 3-hydroxypyrid-4-one in which the hydrogen atom attached to the nitrogen atom is replaced by an aliphatic acyl group, by an aliphatic hydrocarbon group of 1 to 6 carbon atoms, or by an aliphatic hydrocarbon group substituted by one or, except in the case of ionizable groups, more than one substituent selected from aliphatic acyl, alkoxy, aliphatic amine, aliphatic amide, carboxy, aliphatic ester, halogen, hydroxy and sulpho groups and, optionally, in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by one of said substituents, by an aliphatic hydrocarbon group of 1 to 6 carbon atoms, or by an aliphatic hydrocarbon group substituted by an alkoxy, aliphatic ester, halogen or hydroType: GrantFiled: October 31, 1984Date of Patent: May 12, 1987Assignee: National Research Development CorporationInventors: Robert C. Hider, George Kontoghiorghes, Jack Silver, Michael A. Stockham
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Patent number: 4650793Abstract: Pharmaceutical compositions containing an iron complex of a 3-hydroxypyrid-2-one or 3-hydroxypyrid-4-one in which the hydrogen atom attached to the nitrogen atom is replaced by an aliphatic acyl group, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by one or, except in the case of ionizable groups, more than one substituent selected from aliphatic acyl, alkoxy, aliphatic amine, aliphatic amide, carboxy, aliphatic ester, halogen, hydroxy and sulpho groups and, optionally, in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by one of said substituents, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by an alkoxy, aliphatic ester, halogen or hydroxy group, but excluding compounds in which said replacement of hydrogen atoms in the compound is effected only by aliphatic hydrocarbon groups, are of value for the treatment of iron deficiency anemia.Type: GrantFiled: March 22, 1984Date of Patent: March 17, 1987Assignee: National Research Development CorporationInventors: Robert C. Hider, George Kontoghiorghes, Jack Silver, Michael A. Stockham
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Patent number: 4587240Abstract: Compounds which are a 1-hydroxypyrid-2-one in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by a substituent selected from aliphatic acyl, aliphatic amide, aliphatic amine, carboxy, cyano, aliphatic ester, halogen, hydroxy and sulpho groups, alkoxy groups and alkoxy groups substituted by an alkoxy, aliphatic amide, aliphatic amine, aliphatic ester, halogen or hydroxy group, aliphatic hydrocarbon groups and aliphatic hydrocarbon groups substituted by an alkoxy, aliphatic ester, halogen or hydroxy group, but excluding compounds in which said replacement of hydrogen atoms in the compound is effected only by substituents selected from aliphatic hydrocarbon groups, halogen groups and aliphatic hydrocarbon groups substituted by a halogen group, or a salt thereof containing a physiolgically acceptable ion or ions, are of value in the treatment of patients having a toxic concentration of a metal, particularly iron, in the body whilst the iron complexes of such compounds are of valType: GrantFiled: September 18, 1984Date of Patent: May 6, 1986Assignee: National Research Development Corp.Inventors: Robert C. Hider, George Kontoghiorghes, Jack Silver, Michael A. Stockham
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Patent number: 4585780Abstract: Pharmaceutical compositions containing a 3-hydroxypyrid-2-one or 3-hydroxypyrid-4-one in which the hydrogen atom attached to the nitrogen atom is replaced by an aliphatic acyl group, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by one or, except in the case of ionizable groups, more than one substituent selected from aliphatic acyl, alkoxy, aliphatic amine, aliphatic amide, carboxy, aliphatic ester, halogen, hydroxy and sulpho groups and, optionally, in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by one of said substituents, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by an alkoxy, aliphatic ester, halogen or hydroxy group, but excluding compounds in which said replacement of hydrogen atoms in the compound is effected only by aliphatic hydrocarbon groups, or a salt thereof containing a physiologically acceptable ion or ions, are of value for removing toxic amounts of metals, particularly iron,Type: GrantFiled: March 22, 1984Date of Patent: April 29, 1986Assignee: National Research Development Corp.Inventors: Robert C. Hider, George Kontoghiorghes, Jack Silver
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Patent number: 4550101Abstract: Pharmaceutical compositions containing an iron complex of a 3-hydroxypyrid-2-one or 3-hydroxypyrid-4-one in which the hydrogen atom attached to the nitrogen atom is replaced by an aliphatic hydrocarbon group and, optionally, in which one or more of the hydrogen atoms attached to ring carbon atoms are also replaced by an aliphatic hydrocarbon group, are of value for the treatment of iron deficiency anemia.Type: GrantFiled: March 24, 1983Date of Patent: October 29, 1985Assignee: National Research Development CorporationInventors: Robert C. Hider, George Kontoghiorghes, Jack Silver, Michael A. Stockham
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Patent number: RE34313Abstract: Compounds which are a 1-hydroxypyrid-2-one in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by a substituent selected from aliphatic acyl, aliphatic amide, aliphatic amine, carboxy, cyano, aliphatic ester, halogen, hydroxy and sulpho groups, alkoxy groups and alkoxy groups substituted by an alkoxy, aliphatic amide, aliphatic amine, aliphatic ester, halogen or hydroxy group, aliphatic hydrocarbon groups and aliphatic hydrocarbon groups substituted by an alkoxy, aliphatic ester, halogen or hydroxy group, but excluding compounds in which said replacement of hydrogen atoms in the compound is effected only by substituents selected from aliphatic hydrocarbon groups, halogen groups and aliphatic hydrocarbon groups substituted by a halogen group, or a salt thereof containing a physiolgically acceptable ion or ions, are of value in the treatment of patients having a toxic concentration of a metal, particularly iron, in the body whilst the iron complexes of such compounds are of valType: GrantFiled: October 1, 1991Date of Patent: July 13, 1993Assignee: National Research Development CorporationInventors: Robert C. Hider, George Kontoghiorghes, Jack Silver, Michael A. Stockham