Patents by Inventor Jack Spira
Jack Spira has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11896668Abstract: The present invention is directed to novel lyophilized pharmaceutical preparations comprising a cytotoxic dipeptides such as melphalan flufenamide and one or more excipient(s) selected from the group comprising a polysorbate; a polyethylene glycol; ?-cyclodextrin; ocyclodextrin; hydroxypropyl-?-cyclodextrin; sulfobutylether-?-cyclodextrin; lactose; benzyl alcohol; disodium succinate; propylene glycol; Cremophor EL; Dimethyl sulfoxide; D-mannitol; Trehalose; Sucrose and an amino acid. This preparation may be further formulated and is useful in cancer therapy.Type: GrantFiled: April 27, 2022Date of Patent: February 13, 2024Assignee: Oncopeptides ABInventors: Jack Spira, Fredrik Lehmann
-
Publication number: 20220323585Abstract: The present invention is directed to novel lyophilized pharmaceutical preparations comprising a cytotoxic dipeptides such as melphalan flufenamide and one or more excipient(s) selected from the group comprising a polysorbate; a polyethylene glycol; ?-cyclodextrin; ocyclodextrin; hydroxypropyl-?-cyclodextrin; sulfobutylether-?-cyclodextrin; lactose; benzyl alcohol; disodium succinate; propylene glycol; Cremophor EL; Dimethyl sulfoxide; D-mannitol; Trehalose; Sucrose and an amino acid. This preparation may be further formulated and is useful in cancer therapy.Type: ApplicationFiled: April 27, 2022Publication date: October 13, 2022Applicant: ONCOPEPTIDES ABInventors: Jack SPIRA, Fredrik LEHMANN
-
Patent number: 11344622Abstract: The present invention is directed to novel lyophilized pharmaceutical preparations comprising a cytotoxic dipeptides such as melphalan flufenamide and one or more excipient(s) selected from the group comprising a polysorbate; a polyethylene glycol; ?-cyclodextrin; ocyclodextrin; hydroxypropyl-?-cyclodextrin; sulfobutylether-?-cyclodextrin; lactose; benzyl alcohol; disodium succinate; propylene glycol; Cremophor EL; Dimethyl sulfoxide; D-mannitol; Trehalose; Sucrose and an amino acid. This preparation may be further formulated and is useful in cancer therapy.Type: GrantFiled: July 22, 2020Date of Patent: May 31, 2022Assignee: ONCOPEPTIDES ABInventors: Jack Spira, Fredrik Lehmann
-
Patent number: 11191839Abstract: A pharmaceutical composition for treating infertility in a female subject substantially consists of local anesthetic of amide type such as lidocaine, human albumin, viscosity controlling agent selected from recombinant hyaluronic acid and combination of recombinant hyaluronic acid and water-soluble cellulose ether, optionally citrate, glucose, and/or amino acid, water optionally comprising one or more ions selected from the group consisting of sodium, potassium, magnesium, calcium, acetate, chloride, sulfate. Also disclosed is a method of treating infertility by administration of the composition to a female subject in need thereof.Type: GrantFiled: October 11, 2016Date of Patent: December 7, 2021Assignee: ISIFER ABInventor: Jack Spira
-
Patent number: 11040013Abstract: The present invention is directed towards a compacted powder shaped to comprise: a) a substantially annular girdle having opposing circumferential edges, the girdle having a diameter (x); and b) a dome protruding from each of the opposing circumferential edges of the girdle, wherein the height of each dome (hd) from the circumferential edge is, individually, about 0.18x to about 0.28x.Type: GrantFiled: November 9, 2016Date of Patent: June 22, 2021Assignee: Sensidose ABInventor: Jack Spira
-
Patent number: 10869928Abstract: The present invention is directed to novel lyophilized pharmaceutical preparations comprising a cytotoxic dipeptides such as melphalan flufenamide and one or more excipient(s) selected from the group comprising a polysorbate; a polyethylene glycol; ?-cyclodextrin; ocyclodextrin; hydroxypropyl-?-cyclodextrin; sulfobutylether-?-cyclodextrin; lactose; benzyl alcohol; disodium succinate; propylene glycol; Cremophor EL; Dimethyl sulfoxide; D-mannitol; Trehalose; Sucrose and an amino acid. This preparation may be further formulated and is useful in cancer therapy.Type: GrantFiled: December 19, 2019Date of Patent: December 22, 2020Assignee: ONCOPEPTIDES ABInventors: Jack Spira, Fredrik Lehmann
-
Publication number: 20200345848Abstract: The present invention is directed to novel lyophilized pharmaceutical preparations comprising a cytotoxic dipeptides such as melphalan flufenamide and one or more excipient(s) selected from the group comprising a polysorbate; a polyethylene glycol; ?-cyclodextrin; ocyclodextrin; hydroxypropyl-?-cyclodextrin; sulfobutylether-?-cyclodextrin; lactose; benzyl alcohol; diso dium succinate; propylene glycol; Cremophor EL; Dimethyl sulfoxide; D-mannitol; Trehalose; Sucrose and an amino acid. This preparation may be further formulated and is useful in cancer therapy.Type: ApplicationFiled: July 22, 2020Publication date: November 5, 2020Applicant: ONCOPEPTIDES ABInventors: Jack SPIRA, Fredrik LEHMANN
-
Publication number: 20200168310Abstract: A system comprising a prescription-determination-module that is configured to: receive patient-model-data, wherein the patient-model-data comprises one or more dose-effect-parameters that represent how a patient is expected to react to a dose of medicament over time; apply a plurality of different dosage-parameters to the patient-model-data, in order to determine a plurality of dosage-effect-data; apply one or more selection-criteria to the plurality of dosage-effect-data in order to determine one or more of the associated dosage-parameters as selected-dosage-parameters; and provide an output-signal based on the selected-dosage-parameters.Type: ApplicationFiled: May 30, 2018Publication date: May 28, 2020Inventors: Jerker Westin, Ilias Thomas, Mevludin Memedi, Jack Spira
-
Publication number: 20200121794Abstract: The present invention is directed to novel lyophilized pharmaceutical preparations comprising a cytotoxic dipeptides such as melphalan flufenamide and one or more excipient(s) selected from the group comprising a polysorbate; a polyethylene glycol; ?-cyclodextrin; ocyclodextrin; hydroxypropyl-?-cyclodextrin; sulfobutylether-?-cyclodextrin; lactose; benzyl alcohol; disodium succinate; propylene glycol; Cremophor EL; Dimethyl sulfoxide; D-mannitol; Trehalose; Sucrose and an amino acid. This preparation may be further formulated and is useful in cancer therapy.Type: ApplicationFiled: December 19, 2019Publication date: April 23, 2020Applicant: ONCOPEPTIDES ABInventors: Jack SPIRA, Fredrik LEHMANN
-
Patent number: 10543274Abstract: The present invention is directed to novel lyophilized pharmaceutical preparations comprising a cytotoxic dipeptides such as melphalan flufenamide and one or more excipient(s) selected from the group comprising a polysorbate; a polyethylene glycol; ?-cyclodextrin; ocyclodextrin; hydroxypropyl-?-cyclodextrin; sulfobutylether-?-cyclodextrin; lactose; benzyl alcohol; disodium succinate; propylene glycol; Cremophor EL; Dimethyl sulfoxide; D-mannitol; Trehalose; Sucrose and an amino acid. This preparation may be further formulated and is useful in cancer therapy.Type: GrantFiled: April 12, 2019Date of Patent: January 28, 2020Assignee: ONCOPEPTIDES ABInventors: Jack Spira, Fredrik Lehmann
-
Publication number: 20200009252Abstract: The present invention is directed to novel lyophilized pharmaceutical preparations comprising a cytotoxic dipeptides such as melphalan flufenamide and one or more excipient(s) selected from the group comprising a polysorbate; a polyethylene glycol; ?-cyclodextrin; ocyclodextrin; hydroxypropyl-?-cyclodextrin; sulfobutylether-?-cyclodextrin; lactose; benzyl alcohol; disodium succinate; propylene glycol; Cremophor EL; Dimethyl sulfoxide; D-mannitol; Trehalose; Sucrose and an amino acid. This preparation may be further formulated and is useful in cancer therapy.Type: ApplicationFiled: June 28, 2019Publication date: January 9, 2020Applicant: ONCOPEPTIDES ABInventors: Jack SPIRA, Fredrik LEHMANN
-
Publication number: 20190240338Abstract: A pharmaceutical composition for treating infertility in a female subject substantially consists of local anesthetic of amide type such as lidocaine, human albumin, viscosity controlling agent selected from recombinant hyaluronic acid and combination of recombinant hyaluronic acid and water-soluble cellulose ether, optionally citrate, glucose, and/or amino acid, water optionally comprising one or more ions selected from the group consisting of sodium, potassium, magnesium, calcium, acetate, chloride, sulfate. Also disclosed is a method of treating infertility by administration of the composition to a female subject in need thereof.Type: ApplicationFiled: October 11, 2016Publication date: August 8, 2019Inventor: Jack SPIRA
-
Publication number: 20190240332Abstract: The present invention is directed to novel lyophilized pharmaceutical preparations comprising a cytotoxic dipeptides such as melphalan flufenamide and one or more excipient(s) selected from the group comprising a polysorbate; a polyethylene glycol; ?-cyclodextrin; ocyclodextrin; hydroxypropyl-?-cyclodextrin; sulfobutylether-?-cyclodextrin; lactose; benzyl alcohol; disodium succinate; propylene glycol; Cremophor EL; Dimethyl sulfoxide; D-mannitol; Trehalose; Sucrose and an amino acid. This preparation may be further formulated and is useful in cancer therapy.Type: ApplicationFiled: April 12, 2019Publication date: August 8, 2019Applicant: ONCOPEPTIDES ABInventors: Jack SPIRA, Fredrik LEHMANN
-
Patent number: 10322182Abstract: The present invention is directed to novel lyophilized pharmaceutical preparations comprising a cytotoxic dipeptides such as melphalan flufenamide and one or more excipient(s) selected from the group comprising a polysorbate; a polyethylene glycol; ?-cyclodextrin; ocyclodextrin; hydroxypropyl-?-cyclodextrin; sulfobutylether-?-cyclodextrin; lactose; benzyl alcohol; disodium succinate; propylene glycol; Cremophor EL; Dimethyl sulfoxide; D-mannitol; Trehalose; Sucrose and an amino acid. This preparation may be further formulated and is useful in cancer therapy.Type: GrantFiled: August 1, 2016Date of Patent: June 18, 2019Assignee: ONCOPEPTIDES ABInventors: Jack Spira, Fredrik Lehmann
-
Patent number: 10285946Abstract: The present invention is directed to lyophilized pharmaceutical preparations comprising melphalan flufenamide, or pharmaceutically acceptable salts thereof, and sucrose. Further independent claims are directed to methods for their preparation, compositions comprising the lyophilized pharmaceutical preparations and their use in the treatment of cancer.Type: GrantFiled: October 24, 2013Date of Patent: May 14, 2019Assignee: Oncopeptides ABInventors: Jack Spira, Fredrik Lehmann
-
Patent number: 10285947Abstract: The present invention is directed to lyophilized pharmaceutical preparations comprising melphalan flufenamide, or pharmaceutically acceptable salts thereof, methods for their preparation, compositions comprising the lyophilized pharmaceutical preparations and their use in the treatment of cancer.Type: GrantFiled: May 9, 2016Date of Patent: May 14, 2019Assignee: Oncopeptides ABInventors: Jack Spira, Fredrik Lehmann
-
Publication number: 20180325823Abstract: The present invention is directed towards a compacted powder shaped to comprise: a) a substantially annular girdle having opposing circumferential edges, the girdle having a diameter (x); and b) a dome protruding from each of the opposing circumferential edges of the girdle, wherein the height of each dome (hd) from the circumferential edge is, individually, about 0.18x to about 0.28x.Type: ApplicationFiled: November 9, 2016Publication date: November 15, 2018Inventor: Jack SPIRA
-
Patent number: 10098817Abstract: A device for dispensing articles, the device comprising: a conveying member comprising n receptacles, of which n?m are suitable for receiving articles, the receptacles being movable between an article receiving position and an article dispensing position; a sensor for sensing the presence of articles in the receptacles, the sensor positioned between the receiving position and the dispensing position; wherein m of said receptacles is a blank receptacle which is unable to receive an article and the sensor is unable to distinguish an empty receptacle from a blank receptacle such that the maximum number of detectable articles conveyed once n receptacles have passed the sensor is n?m, where m is at least 1.Type: GrantFiled: January 24, 2014Date of Patent: October 16, 2018Assignee: Sensidose ABInventors: Lars Tegborg, Jack Spira
-
Publication number: 20170049894Abstract: The present invention is directed to novel lyophilized pharmaceutical preparations comprising a cytotoxic dipeptides such as melphalan flufenamide and one or more excipient(s) selected from the group comprising a polysorbate; a polyethylene glycol; ?-cyclodextrin; ocyclodextrin; hydroxypropyl-?-cyclodextrin; sulfobutylether-?-cyclodextrin; lactose; benzyl alcohol; disodium succinate; propylene glycol; Cremophor EL; Dimethyl sulfoxide; D-mannitol; Trehalose; Sucrose and an amino acid. This preparation may be further formulated and is useful in cancer therapy.Type: ApplicationFiled: August 1, 2016Publication date: February 23, 2017Applicant: ONCOPEPTIDES ABInventors: Jack SPIRA, Fredrik LEHMANN
-
Publication number: 20160271065Abstract: The present invention is directed to lyophilized pharmaceutical preparations comprising melphalan flufenamide, or pharmaceutically acceptable salts thereof, methods for their preparation, compositions comprising the lyophilized pharmaceutical preparations and their use in the treatment of cancer.Type: ApplicationFiled: May 9, 2016Publication date: September 22, 2016Applicant: ONCOPEPTIDES ABInventors: Jack SPIRA, Fredrik LEHMANN