Patents by Inventor Jack Zilfou

Jack Zilfou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20110313021
    Abstract: The majority of human cancers inactivate the p53 tumor suppressor network, and consequently, p53 is one of the most studied proteins in cancer biology. Peering into the intricacies of the p53 network should provide insight into the etiology of cancer, which may lead to the identification of molecular targets for therapeutic intervention. p53 carries out its tumor suppressor functions by inducing potent biological outputs, such as programmed cell death, in cells destined for becoming cancerous. p53 is a transcription factor that can regulate expression of numerous genes. The present invention discloses a novel method of rapidly determining the critical p53 target genes that can be utilized for therapeutic intervention. Additionally, this invention discloses suppression of MCAK as a treatment of human cancers and other diseases where p53 levels are elevated.
    Type: Application
    Filed: June 20, 2011
    Publication date: December 22, 2011
    Inventor: Jack Zilfou
  • Publication number: 20100186097
    Abstract: The invention provides, among other things, methods for performing RNA interference in stem cells and methods for using the stem cells in vivo.
    Type: Application
    Filed: July 6, 2009
    Publication date: July 22, 2010
    Applicant: Cold Spring Harbor Laboratory
    Inventors: Scott W. LOWE, Michael HEMANN, Gregory J. HANNON, Patrick J. PADDISON, Jack ZILFOU, Jordan FRIDMAN, Michelle A. CARMELL, Ross DICKINS, Thomas A. ROSENQUIST, Stephen J. ELLEDGE
  • Publication number: 20090217404
    Abstract: The invention provides, among other things, methods for performing RNA interference (RNAi) in stem cells (such as embryonic stem cells) and methods for using such stem cells in vivo. The invention also provides various animal models based on conditional/inducible, reversible, tissue-specific/spacial, and/or developmental stage-specific/temporal RNAi of certain target genes, which animal model may be useful for, e.g., drug target identification and/or validation.
    Type: Application
    Filed: February 23, 2008
    Publication date: August 27, 2009
    Inventors: Scott W. Lowe, Michelle A. Carmell, Gregory J. Hannon, Patrick Paddison, Jack Zilfou, Jordan Fridman, Ross Dickins, Michael Hemann, Thomas A. Rosenquist, Prem Premsrirut
  • Publication number: 20080226553
    Abstract: This invention provides, among other things, methods for performing RNA interference in stem cells and methods for using stem cells in vivo.
    Type: Application
    Filed: September 29, 2003
    Publication date: September 18, 2008
    Applicant: Cold Spring Harbor Laboratory
    Inventors: Scott W. Lowe, Michelle A. Carmell, Gregory J. Hannon, Patrick J. Paddison, Jack Zilfou, Jordan Fridman, Michelle A. Carmell, Ross Dickins, Thomas A. Rosenquist, Stephen J. Elledge