Abstract: A syringe is disclosed having a large syringe housing which can be fitted with a large needle holder which in turn holds a large introducer needle. The introducer needle defines a passageway. A small seeker needle which is designed to fit within and through the passageway of the large introducer needle is attached by way of a small needle holder to a small syringe housing. A washer adapter attaches to the front of the small needle holder in order to have the small syringe housing move within a large syringe housing as a plunger for the large syringe housing. The small syringe housing in turn receives on one end a small syringe plunger which may define a small plunger lumen or chamber which can be used for transduction. Another embodiment has a modified needle having a port in the shaft within the syringe to allow sampling.