Abstract: Aspects and embodiments of the present invention generally include a device for patient self-administration of a prescribed medication. The device makes available for administration the precise quantity of medication constituting a dose at times designated by a health care provider (HCP). Preferably, the device also detects and transmits information to a remote management system accessible to the HCP, including detected attempts to tamper with the device. Advantageously, HCPs may render oversight and control over the device and its use to mitigate risks associated with patients self-administering medication without in-person supervision. This control may include establishing prerequisites the patient must meet prior to a dose being made available, or remote deactivation of the device. This oversight by the HCP may include patient-specific and aggregate data analysis for optimization of treatment or evaluation of the safety and efficacy of a treatment.

Abstract: A brassiere for enhancing cleavage between the breasts of a wearer and including a torso shaping body member, which can be worn under a garment which is strapless, off the shoulder and/or cut low in the back. The present invention comprises a pair of breast cups disposed in spaced apart yet communicating relation with one another. Each breast cup preferably includes an upper half and a lower half and an underwire which is structured and disposed to wrap substantially around each breast of the wearer so as to effectively lift the breasts upwardly. As a unique feature, the improved brassier of the present invention includes a tensioner member interposed between the breast cups and preferably, which has a generally "V" shape, so as to effectively squeeze the breasts together. The present invention additionally comprises a body member, with optional straps for securing the brassier about the torso of the wearer in proper orientation so that the breast cups are disposed to support the wearer's breasts.