Patents by Inventor Jacob Becraft

Jacob Becraft has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • EXPRESSION CONSTRUCTS AND USES THEREOF
    Publication number: 20240166707
    Abstract: The present disclosure relates to an isolated polynucleotide comprising a sequence that encodes an interleukin (IL)-12 molecule, and a delivery system that can carry the polynucleotides. The disclosure also includes methods of making the polynucleotides and methods of treatment using the same.
    Type: Application
    Filed: January 10, 2022
    Publication date: May 23, 2024
    Applicant: STRAND THERAPEUTICS INC.
    Inventors: Tasuku KITADA, Jacob BECRAFT, Ryan SOWELL, Jaspreet KHURANA, Anna SIMON, Joseph BARBERIO, Weiyu ZHAO, Alexander LEMAIRE, Aalok SHAH
  • LIPID NANOPARTICLE COMPRISING MODIFIED NUCLEOTIDES
    Publication number: 20230295257
    Abstract: The present disclosure relates to a lipid nanoparticle comprising (i) one or more types of lipid; and (ii) a modified mRNA comprising a sequence that encodes an interleukin (IL)-12 molecule, wherein the lipid nanoparticle is capable of triggering immunogenic cell death, and methods of treatment using the same
    Type: Application
    Filed: July 26, 2021
    Publication date: September 21, 2023
    Applicant: STRAND THERAPEUTICS INC.
    Inventors: Jacob BECRAFT, Ryan SOWELL, Jaspreet KHURANA, Tasuku KITADA
  • RNA-BASED LOGIC CIRCUITS WITH RNA BINDING PROTEINS, APTAMERS AND SMALL MOLECULES
    Publication number: 20220395585
    Abstract: Engineered synthetic RNA-based genetic circuits are provided that are regulated exclusively at the post-transcriptional level.
    Type: Application
    Filed: May 3, 2022
    Publication date: December 15, 2022
    Applicants: Massachusetts Institute of Technology, Kyoto University
    Inventors: Ron Weiss, Liliana Wroblewska, Velia Siciliano, Tasuku Kitada, Maria Hottelet Foley, Katie Bodner, Hirohide Saito, Kei Endo, Darrell J. Irvine, Tyler Wagner, Jacob Becraft
  • RNA-based logic circuits with RNA binding proteins, aptamers and small molecules
    Patent number: 11351271
    Abstract: Engineered synthetic RNA-based genetic circuits are provided that are regulated exclusively at the post-transcriptional level.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: June 7, 2022
    Assignees: Massachusetts Institute of Technology, Kyoto University
    Inventors: Ron Weiss, Liliana Wroblewska, Velia Siciliano, Tasuku Kitada, Maria Hottelet Foley, Katie Bodner, Hirohide Saito, Kei Endo, Darrell J. Irvine, Tyler Wagner, Jacob Becraft
  • DNA LAUNCHED RNA REPLICON SYSTEM (DREP) AND USES THEREOF
    Publication number: 20200283796
    Abstract: Provided herein, in some aspects, are antibody expression systems comprising DNA launched RNA replicons for high level antibody expression. In some embodiments, the antibody is a therapeutic antibody. In some embodiments, the antibody is an immune check point inhibitor. Methods of using the antibody expression system for treating diseases (e.g., cancer) are also provided.
    Type: Application
    Filed: March 5, 2020
    Publication date: September 10, 2020
    Applicant: Massachusetts Institute of Technology
    Inventors: Ron Weiss, Jin Huh, Jacob Becraft
  • RNA-BASED LOGIC CIRCUITS WITH RNA BINDING PROTEINS, APTAMERS AND SMALL MOLECULES
    Publication number: 20190151474
    Abstract: Engineered synthetic RNA-based genetic circuits are provided that are regulated exclusively at the post-transcriptional level.
    Type: Application
    Filed: September 8, 2015
    Publication date: May 23, 2019
    Applicants: Massachusetts Institute of Technology, Kyoto University
    Inventors: Ron Weiss, Liliana Wroblewska, Velia Siciliano, Tasuku Kitada, Maria Hottelet Foley, Katie Bodner, Hirohide Saito, Kei Endo, Darrell J. Irvine, Tyler Wagner, Jacob Becraft
  • RNA-BASED LOGIC CIRCUITS WITH RNA BINDING PROTEINS, APTAMERS AND SMALL MOLECULES
    Publication number: 20180296702
    Abstract: Engineered synthetic RNA-based genetic circuits are provided that are regulated exclusively at the post-transcriptional level.
    Type: Application
    Filed: September 8, 2015
    Publication date: October 18, 2018
    Applicants: Massachusetts Institute of Technology, Kyoto University
    Inventors: Ron Weiss, Liliana Wroblewska, Velia Siciliano, Tasuku Kitada, Maria Hottelet Foley, Katie Bodner, Hirohide Saito, Kei Endo, Darrell J. Irvine, Tyler Wagner, Jacob Becraft