Abstract: The present disclosure generally relates to a magnesium alloy including about 2-7% by weight zinc; about 0.2-3% by weight calcium; about 0-1.0% by weight of an alloying element; and a balance of magnesium. The magnesium alloy may include a ternary absorption profile including a first absorption rate, second absorption rate, and third absorption rate, the second absorption rate being approximately slower than the first absorption rate and the third absorption rate. The magnesium alloy may be formed as a portion or more of a bodily implant.

Abstract: A prosthetic knee includes a hydraulic resistance system with an extension hydraulic circuit and a flexion hydraulic circuit. The flexion hydraulic circuit includes a switchable resistance assembly with a mechanical switch. The mechanical switch has an engaged position and a released position. The switchable resistance assembly provides a first level of hydraulic resistance when the mechanical switch is in the released position and a second level of hydraulic resistance when the mechanical switch is in the engaged position, the second level being less than the first level. The mechanical switch moves to the engaged position when the hydraulic resistance element reaches a predetermined extension position and moves back to the released position when fluid flow falls below a predetermined threshold.

Abstract: A bioerodible endoprosthesis includes a bioerodible magnesium alloy. The bioerodible magnesium alloy has magnesium and one or more additional alloying elements, including aluminum. The alloy has a microstructure comprising equiaxed Mg-rich solid solution phase grains having an average grain diameter of less than or equal to 5 microns and continuous or discontinuous second-phase precipitates in grain boundaries between the Mg-rich solid solution-phase grains, the second-phase precipitates having an average longest dimension of 0.5 micron or less.

Abstract: A prosthetic knee includes a hydraulic resistance system with an extension hydraulic circuit and a flexion hydraulic circuit. The flexion hydraulic circuit includes a switchable resistance assembly with a mechanical switch. The mechanical switch has an engaged position and a released position. The switchable resistance assembly provides a first level of hydraulic resistance when the mechanical switch is in the released position and a second level of hydraulic resistance when the mechanical switch is in the engaged position, the second level being less than the first level. The mechanical switch moves to the engaged position when the hydraulic resistance element reaches a predetermined extension position and moves back to the released position fluid flow falls below a predetermined threshold.

Abstract: A hydraulic prosthetic device has upper and lower portions and a hydraulic cylinder coupled thereto for damping relative motion. The cylinder has a movable piston and a first and second chamber. A three-way valve includes a housing and a movable portion cooperating to define a hydraulic circuit. The movable portion has a master port, an inlet port and an outlet port, and the housing has an inlet opening, an outlet opening, and a master opening each positioned to fluidly communicate with the respective port. The inlet port and/or the inlet opening, and the outlet port and/or the outlet opening are shaped such that movement of the movable portion of the valve relative to the housing varies a resistance to the fluid flow related to movement or the prosthetic portions in both directions.

Abstract: A bioerodible endoprosthesis includes a bioerodible body including an alloy comprising at least 85 weight percent magnesium and at least one high-melting-temperature element having a melting temperature of greater than 700° C. The alloy has a microstructure including equiaxed magnesium-rich phase grains and optionally high-melting-temperature intermetallic phases. The equiaxed magnesium-rich phase grains have an average grain diameter of less than or equal to 10 microns. High-melting-temperature intermetallic phases, if present, can have an average longest dimension of 3 microns or less.

Abstract: A bioerodible endoprosthesis includes a bioerodible magnesium alloy including between 50 weight percent and 92 weight percent magnesium, at least 5.5 weight percent in sum of one or more elements selected from the group consisting of Ho, Er, Lu, Tb and Tm, and at least 2.0 weight percent in sum of one or more elements selected from the group consisting of Y, Nd and Gd. The bioerodible magnesium alloy has a microstructure including equiaxed Mg-rich solid solution-phase grains having an average grain diameter of less than or equal to 15 microns and second-phase precipitates and/or ceramic nanoparticles in grain boundaries between the equiaxed Mg-rich solid solution-phase grains. The secondary-phase precipitates or ceramic nanoparticles have an average longest dimension of 2.0 micron or less. The microstructure can be produced by one or more equal-channel high-strain processes.

Abstract: Disclosed herein are systems and methods for data learning and classification for rapidly processing extremely large volumes of input data using one or more computing devices, that are application and platform independent, participating in a distributed parallel processing environment. In one embodiments, a system may comprise a plurality of parallel Map Reduction Aggregation Processors operating on the one or more computing devices, and configured to receive different sets of input data for data aggregation.

Abstract: A bioerodible endoprosthesis includes a bioerodible magnesium alloy. The bioerodible magnesium alloy has a microstructure including equiaxed Mg-rich solid solution-phase grains having an average grain diameter of less than or equal to 5 microns and second-phase precipitates in grain boundaries between the equiaxed Mg-rich solid solution-phase grains. The beta-phase precipitates have an average longest dimension of 0.5 micron or less. The microstructure can be produced by one or more equal-channel high-strain processes.

Abstract: A bioerodible endoprosthesis includes a bioerodible magnesium alloy. The bioerodible magnesium alloy has a microstructure including equiaxed Mg-rich solid solution-phase grains having an average grain diameter of less than or equal to 5 microns and second-phase precipitates in grain boundaries between the equiaxed Mg-rich solid solution-phase grains. The beta-phase precipitates have an average longest dimension of 0.5 micron or less. The microstructure can be produced by one or more equal-channel high-strain processes.

Abstract: A bioerodible endoprosthesis includes a bioerodible magnesium alloy including between 50 weight percent and 92 weight percent magnesium, at least 5.5 weight percent in sum of one or more elements selected from the group consisting of Ho, Er, Lu, Tb and Tm, and at least 2.0 weight percent in sum of one or more elements selected from the group consisting of Y, Nd and Gd. The bioerodible magnesium alloy has a microstructure including equiaxed Mg-rich solid solution-phase grains having an average grain diameter of less than or equal to 15 microns and second-phase precipitates and/or ceramic nanoparticles in grain boundaries between the equiaxed Mg-rich solid solution-phase grains. The secondary-phase precipitates or ceramic nanoparticles have an average longest dimension of 2.0 micron or less. The microstructure can be produced by one or more equal-channel high-strain processes.

Abstract: A bioerodible endoprosthesis includes a bioerodible magnesium alloy including between 50 weight percent and 92 weight percent magnesium, at least 5.5 weight percent in sum of one or more elements selected from the group consisting of Ho, Er, Lu, Tb and Tm, and at least 2.0 weight percent in sum of one or more elements selected from the group consisting of Y, Nd and Gd. The bioerodible magnesium alloy has a microstructure including equiaxed Mg-rich solid solution-phase grains having an average grain diameter of less than or equal to 15 microns and second-phase precipitates and/or ceramic nanoparticles in grain boundaries between the equiaxed Mg-rich solid solution-phase grains. The secondary-phase precipitates or ceramic nanoparticles have an average longest dimension of 2.0 micron or less. The microstructure can be produced by one or more equal-channel high-strain processes.

Abstract: A bioerodible endoprosthesis includes a composite including a matrix comprising a bioerodible magnesium alloy and a plurality of ceramic nanoparticles within the matrix. The bioerodible magnesium alloy has a microstructure including equiaxed Mg-rich solid solution-phase grains having an average grain diameter of less than or equal to 5 microns. The microstructure can be produced by one or more equal-channel high-strain processes.

Abstract: A bioerodible endoprosthesis includes a bioerodible body including an alloy comprising at least 85 weight percent magnesium and at least one high-melting-temperature element having a melting temperature of greater than 700° C. The alloy has a microstructure including equiaxed magnesium-rich phase grains and optionally high-melting-temperature intermetallic phases. The equiaxed magnesium-rich phase grains have an average grain diameter of less than or equal to 10 microns. High-melting-temperature intermetallic phases, if present, can have an average longest dimension of 3 microns or less.

Abstract: A stent delivery catheter comprising at least one catheter shaft, the catheter shaft having an inner surface and an outer surface and a distal end and a proximal end, the catheter shaft defining a guidewire lumen, the guidewire lumen comprising a diameter defined by the inner surface of the catheter shaft, a stent disposed within the distal end of the catheter shaft and in contact with the inner surface of the catheter shaft, and a stylet disposed within the distal end of the catheter shaft, the stylet comprising a wave geometry.

Abstract: A bioerodible endoprosthesis includes a bioerodible magnesium alloy including between 50 weight percent and 92 weight percent magnesium, at least 5.5 weight percent in sum of one or more elements selected from the group consisting of Ho, Er, Lu, Tb and Tm, and at least 2.0 weight percent in sum of one or more elements selected from the group consisting of Y, Nd and Gd. The bioerodible magnesium alloy has a microstructure including equiaxed Mg-rich solid solution-phase grains having an average grain diameter of less than or equal to 15 microns and second-phase precipitates and/or ceramic nanoparticles in grain boundaries between the equiaxed Mg-rich solid solution-phase grains. The secondary-phase precipitates or ceramic nanoparticles have an average longest dimension of 2.0 micron or less. The microstructure can be produced by one or more equal-channel high-strain processes.

Abstract: A bioerodible endoprosthesis includes a composite including a matrix comprising a bioerodible magnesium alloy and a plurality of ceramic nanoparticles within the matrix. The bioerodible magnesium alloy has a microstructure including equiaxed Mg-rich solid solution-phase grains having an average grain diameter of less than or equal to 5 microns. The microstructure can be produced by one or more equal-channel high-strain processes.

Abstract: A bioerodible endoprosthesis includes a bioerodible magnesium alloy. The bioerodible magnesium alloy has a microstructure including equiaxed Mg-rich solid solution-phase grains having an average grain diameter of less than or equal to 5 microns and second-phase precipitates in grain boundaries between the equiaxed Mg-rich solid solution-phase grains. The beta-phase precipitates have an average longest dimension of 0.5 micron or less. The microstructure can be produced by one or more equal-channel high-strain processes.

Abstract: Disclosed herein are systems and methods for data learning and classification for rapidly processing extremely large volumes of input data using one or more computing devices, that are application and platform independent, participating in a distributed parallel processing environment. In one embodiments, a system may comprise a plurality of parallel Map Reduction Aggregation Processors operating on the one or more computing devices, and configured to receive different sets of input data for data aggregation.