Patents by Inventor Jacob FREAKE
Jacob FREAKE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11820966Abstract: A perfusion manifold assembly is described that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate. A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body.Type: GrantFiled: December 30, 2019Date of Patent: November 21, 2023Assignee: EMULATE, INC.Inventors: Christopher David Hinojosa, Guy Robert Thompson, II, Joshua Gomes, Jacob Freake, Doug Sabin
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Publication number: 20230058647Abstract: This disclosure describes hardware for microfluidic chips and an associated support module for facilitating operation of one or more microfluidic chips. The microfluidic chips described herein are designed for supporting multiple different tissue types, including kidney tissue, liver tissue, adipose cells, and so forth. Chip geometry facilities fluid flow through one or more channels of the chip with a particular flow rate. For example, shear forces are reduced where needed to ensure proper flow rate of fluid in the channels. The chamber geometry and the geometry of the channels ensures that a desired amount of oxygen is delivered to sample cells or tissues in a controlled manner.Type: ApplicationFiled: August 19, 2022Publication date: February 23, 2023Inventors: Murat Cirit, Douglas G. Sabin, Peter Conway, Jacob Freake, Corbin Munn, Joseph Von Shoppe, Renee Hester, Emily Geishecker, Shiny Rajan, Abraham LeMole
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Publication number: 20220403312Abstract: A perfusion manifold assembly is described that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate. A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body.Type: ApplicationFiled: December 30, 2019Publication date: December 22, 2022Inventors: Christopher David Hinojosa, Guy Robert Thompson, Joshua Gomes, Jacob Freake, Doug Sabin
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Publication number: 20220396836Abstract: Samples, systems for collecting samples, and methods of preserving samples from menstrual fluid are provided.Type: ApplicationFiled: October 30, 2020Publication date: December 15, 2022Inventors: Stephen GIRE, Ridhi TARIYAL, Trevor RUGGIERO, Adrienne CLARK, Corbin MUNN, Jacob FREAKE
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Patent number: 11311009Abstract: An incubator assembly includes an incubator enclosure having an internal chamber in which a controlled environment is maintained and which is defined by one or more walls. The incubator assembly further includes a jacket assembly mounted adjacent to at least one of the walls and having an internal airspace in which an internal fluid is enclosed for maintaining a homogenous temperature within the internal chamber. The jacket assembly further has a vent movable between a plurality of positions including an open position in which the internal fluid is allowed to exit the internal airspace into an ambient environment.Type: GrantFiled: March 17, 2016Date of Patent: April 26, 2022Assignee: President and Fellows of Harvard CollegeInventors: Jacob Freake, Josh Gomes, Christopher David Hinojosa, Daniel Levner, Doug Sabin, Guy Thompson, II
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Publication number: 20220093006Abstract: Provided are stomach simulating devices and methods for simulating a stomach. Stomach simulating devices can comprise a bag-shaped conduit, a mechanical constrictor, and a valve. The conduit can have a body portion, a first diameter at an inlet portion, and a second diameter at an outlet portion, wherein the first diameter at the inlet portion is greater than the second diameter at the outlet portion, the body portion is located between the inlet portion and the outlet portion, and at least a portion of the conduit is curved in a direction from the inlet portion the outlet portion. The mechanical constrictor can he configured to constrict at least a portion of the body portion of the conduit. The valve can be configured to at least partially close a portion of the conduit closer to the outlet portion than the inlet portion of the conduit.Type: ApplicationFiled: December 3, 2019Publication date: March 24, 2022Inventors: Rosemary KANASTY, Tyler GRANT, John James HEALY, Benjamin August Rothenberg PETERSON, Todd William ROBERTS, Nathan Andrew HERRMANN, Erik Robert Waldemar RYDE, David C. DUFOUR, Carmi MANDELKERN, Jacob FREAKE, Kristofer KURTIN, Doug SABIN
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Patent number: 10988722Abstract: The invention relates to a perfusion manifold assembly that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with an assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.Type: GrantFiled: December 19, 2018Date of Patent: April 27, 2021Assignee: EMULATE, Inc.Inventors: Daniel Levner, Josiah Daniel Sliz, Christopher David Hinojosa, Guy Robert Thompson, II, Petrus Wilhelmus Martinus van Ruijven, Matthew Daniel Solomon, Christian Alexander Potzner, Patrick Sean Tuohy, Joshua Gomes, Norman Wen, Jacob Freake, Doug Sabin
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Publication number: 20200190455Abstract: A perfusion manifold assembly is described that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate. A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body.Type: ApplicationFiled: December 30, 2019Publication date: June 18, 2020Inventors: Christopher David Hinojosa, Guy Robert Thompson, Joshua Gomes, Jacob Freake, Doug Sabin
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Patent number: 10519410Abstract: A perfusion manifold assembly is described that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate. A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body.Type: GrantFiled: December 17, 2018Date of Patent: December 31, 2019Assignee: Emulate, IncInventors: Christopher David Hinojosa, Guy Robert Thompson, II, Joshua Gomes, Jacob Freake, Doug Sabin
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Publication number: 20190169557Abstract: A perfusion manifold assembly is described that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate. Drop-to-drop connection schemes are described for putting a microfluidic device in fluidic communication with a fluid source or another microfluidic device, including but not limited to, putting a microfluidic device in fluidic communication with the perfusion manifold assembly.Type: ApplicationFiled: December 19, 2018Publication date: June 6, 2019Inventors: Daniel Levner, Josiah Daniel Sliz, Christopher David Hinojosa, Guy Robert Thompson, II, Petrus Wilhelmus Martinus van Ruijven, Matthew Daniel Solomon, Christian Alexander Potzner, Patrick Sean Tuohy, Joshua Gomes, Norman Wen, Jacob Freake, Doug Sabin
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Patent number: 10273441Abstract: The invention relates to a perfusion manifold assembly that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with an assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate. The invention further relates to a drop-to-drop connection scheme for putting a microfluidic device in fluidic communication with a fluid source or another microfluidic device, including but not limited to, putting a microfluidic device in fluidic communication with the perfusion manifold assembly.Type: GrantFiled: August 26, 2016Date of Patent: April 30, 2019Assignee: EMULATE, Inc.Inventors: Daniel Levner, Josiah Daniel Sliz, Christopher David Hinojosa, Guy Robert Thompson, II, Petrus Wilhelmus Martinus van Ruijven, Matthew Daniel Solomon, Christian Alexander Potzner, Patrick Sean Tuohy, Joshua Gomes, Norman Wen, Jacob Freake, Doug Sabin
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Publication number: 20190112566Abstract: A perfusion manifold assembly is described that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate. A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body.Type: ApplicationFiled: December 17, 2018Publication date: April 18, 2019Inventors: Christopher David Hinojosa, Guy Robert Thompson, II, Joshua Gomes, Jacob Freake, Doug Sabin
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Patent number: 10233416Abstract: A perfusion manifold assembly is described that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate. A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body.Type: GrantFiled: August 26, 2016Date of Patent: March 19, 2019Assignee: EMULATE, INC.Inventors: Christopher David Hinojosa, Guy Robert Thompson, II, Joshua Gomes, Jacob Freake, Doug Sabin
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Publication number: 20180363683Abstract: Systems and methods for providing a soft robot is provided. In one system, a robotic device includes a flexible body having a fluid chamber, where a portion of the flexible body includes an elastically extensible material and a portion of the flexible body is strain limiting relative to the elastically extensible material. The robotic device can further include a pressurizing inlet in fluid communication with the fluid chamber, and a pressurizing device in fluid communication with the pressurizing inlet, the pressurizing device including a reaction chamber configured to accommodate a gas-producing chemical reaction for providing pressurized gas to the pressurizing inlet.Type: ApplicationFiled: April 13, 2018Publication date: December 20, 2018Inventors: Robert F. SHEPHERD, Adam STOKES, Stephen A. MORIN, Ludovico CADEMARTIRI, Jacob FREAKE, Rui NUNES, Xin CHEN, George M. WHITESIDES
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Patent number: 9945397Abstract: Systems and methods for providing a soft robot is provided. In one system, a robotic device includes a flexible body having a fluid chamber, where a portion of the flexible body includes an elastically extensible material and a portion of the flexible body is strain limiting relative to the elastically extensible material. The robotic device can further include a pressurizing inlet in fluid communication with the fluid chamber, and a pressurizing device in fluid communication with the pressurizing inlet, the pressurizing device including a reaction chamber configured to accommodate a gas-producing chemical reaction for providing pressurized gas to the pressurizing inlet.Type: GrantFiled: April 2, 2014Date of Patent: April 17, 2018Assignee: President and Fellows of Harvard CollegeInventors: Robert F. Shepherd, Adam Stokes, Stephen A. Morin, Ludovico Cademartiri, Jacob Freake, Rui Nunes, Xin Chen, George M. Whitesides
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Publication number: 20180049430Abstract: An incubator assembly includes an incubator enclosure having an internal chamber in which a controlled environment is maintained and which is defined by one or more walls. The incubator assembly further includes a jacket assembly mounted adjacent to at least one of the walls and having an internal airspace in which an internal fluid is enclosed for maintaining a homogenous temperature within the internal chamber. The jacket assembly further has a vent movable between a plurality of positions including an open position in which the internal fluid is allowed to exit the internal airspace into an ambient environment.Type: ApplicationFiled: March 17, 2016Publication date: February 22, 2018Inventors: Jacob Freake, Josh Gomes, Christopher David Hinojosa, Daniel Levner, Doug Sabin, Guy Thompson, II
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Publication number: 20170055522Abstract: A perfusion manifold assembly is described that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate. Drop-to-drop connection schemes are described for putting a microfluidic device in fluidic communication with a fluid source or another microfluidic device, including but not limited to, putting a microfluidic device in fluidic communication with the perfusion manifold assembly.Type: ApplicationFiled: August 26, 2016Publication date: March 2, 2017Inventors: Daniel Levner, Josiah Daniel Sliz, Christopher David Hinojosa, Guy Robert Thompson, Petrus Wilhelmus Martinus van Ruijven, Matthew Daniel Solomon, Christian Alexander Potzner, Patrick Sean Tuohy, Joshua Gomes, Norman Wen, Jacob Freake, Doug Sabin
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Publication number: 20170058248Abstract: A perfusion manifold assembly is described that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate. A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body.Type: ApplicationFiled: August 26, 2016Publication date: March 2, 2017Inventors: Christopher David Hinojosa, Guy Robert Thompson, Joshua Gomes, Jacob Freake, Doug Sabin
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Publication number: 20170030381Abstract: Systems and methods for providing a soft robot is provided. In one system, a robotic device includes a flexible body having a fluid chamber, where a portion of the flexible body includes an elastically extensible material and a portion of the flexible body is strain limiting relative to the elastically extensible material. The robotic device can further include a pressurizing inlet in fluid communication with the fluid chamber, and a pressurizing device in fluid communication with the pressurizing inlet, the pressurizing device including a reaction chamber configured to accommodate a gas-producing chemical reaction for providing pressurized gas to the pressurizing inlet.Type: ApplicationFiled: April 2, 2014Publication date: February 2, 2017Applicant: President and Fellows of Harvard CollegeInventors: Robert F. SHEPHERD, Adam STOKES, Stephen A. MORIN, Ludovico CADEMARTIRI, Jacob FREAKE, Rui NUNES, Xin CHEN, George M. WHITESIDES
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Publication number: 20140208731Abstract: Systems and methods for providing a soft robot is provided. In one system, a robotic device includes a flexible body having a fluid chamber, where a portion of the flexible body includes an elastically extensible material and a portion of the flexible body is strain limiting relative to the elastically extensible material. The robotic device can further include a pressurizing inlet in fluid communication with the fluid chamber, and a pressurizing device in fluid communication with the pressurizing inlet, the pressurizing device including a reaction chamber configured to accommodate a gas-producing chemical reaction for providing pressurized gas to the pressurizing inlet.Type: ApplicationFiled: April 2, 2014Publication date: July 31, 2014Applicant: President and Fellows of Harvard CollegeInventors: Robert F. SHEPHERD, Adam STOKES, Stephen A. MORIN, Ludovico CADEMARTIRI, Jacob FREAKE, Rui NUNES, Xin CHEN, George M. WHITESIDES