Patents by Inventor Jacob K. Freudenthal
Jacob K. Freudenthal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240159677Abstract: An instrument for processing and/or measuring a biological process comprises a plurality of filter assemblies configured to be interchangeably located along at least one of the optical paths. The plurality of filter components includes a first filter assembly characterized by a first optical power and a first filter having a first filter function, the first filter function characterized by at least one of a first low-pass wavelength or a first high-pass wavelength. The second filter assembly is characterized by a second optical power and a second filter having a second filter function, the second filter function comprising at least one of a second low-pass wavelength that is different than the first low-pass wavelength or a second high-pass wavelength that is different than the first high-pass wavelength.Type: ApplicationFiled: November 9, 2023Publication date: May 16, 2024Inventors: Kevin MAHER, Mingsong CHEN, Jacob K. FREUDENTHAL, Kuan Moon BOO, Soo Yong LAU, David FORTESCUE, Ming SHEN, Woon Liang Terence SOH
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Patent number: 11815460Abstract: A method of analyzing a plurality of biological sample volumes comprises emitting, along an excitation optical path toward a sample holder holding the plurality of biological sample volumes, electromagnetic radiation from a broadband LED, wherein the broadband LED emits the electromagnetic radiation across a range of wavelengths at a total output power of at least 5 watts and at a maximum intensity at a wavelength less than 600 nanometers and at an intensity less than 30 percent of the maximum intensity at a wavelength of 650 or 670 nanometers, and receiving, by a sensor, an electromagnetic emission transmitted from the sample holder along an emission optical path.Type: GrantFiled: May 26, 2022Date of Patent: November 14, 2023Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Kevin Maher, Mingsong Chen, Jacob K. Freudenthal, Kuan Moon Boo, Soo Yong Lau, David Fortescue, Ming Shen, Woon Liang Terence Soh
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Publication number: 20230106558Abstract: An instrument for processing and/or measuring a biological process comprises a sample processing system and an excitation source exhibiting a spectral function of output power or intensity verses wavelength of output power or intensity. The spectral function has a minima wavelength corresponding to a local minima value of the output power or intensity; a first maxima wavelength corresponding to a first local maxima of output power or intensity, the output power or intensity at the first local maxima being greater than the output power or intensity at any wavelength less than the minima wavelength; a second maxima wavelength corresponding to a second local maxima of output power or intensity, the output power or intensity at the second local maxima being greater than the output at any wavelength greater than the minima wavelength; the minima wavelength is between the first maxima wavelength and the second maxima wavelength.Type: ApplicationFiled: October 7, 2022Publication date: April 6, 2023Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Mingsong CHEN, Mauro AGUANNO, Kuan Moon BOO, Woon Liang Terence SOH, Jacob K. FREUDENTHAL, Jeffrey A. MARKS
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Publication number: 20220412890Abstract: An instrument for processing and/or measuring a biological process comprises a plurality of filter assemblies configured to be interchangeably located along at least one of the optical paths. The plurality of filter components includes a first filter assembly characterized by a first optical power and a first filter having a first filter function, the first filter function characterized by at least one of a first low-pass wavelength or a first high-pass wavelength. The second filter assembly is characterized by a second optical power and a second filter having a second filter function, the second filter function comprising at least one of a second low-pass wavelength that is different than the first low-pass wavelength or a second high-pass wavelength that is different than the first high-pass wavelength.Type: ApplicationFiled: May 26, 2022Publication date: December 29, 2022Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Kevin MAHER, Mingsong CHEN, Jacob K. FREUDENTHAL, Kuan Moon BOO, Soo Yong LAU, David FORTESCUE, Ming SHEN, Woon Liang Terence SOH
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Patent number: 11467092Abstract: An instrument for processing and/or measuring a biological process contains a sample processing system, an excitation source, an excitation optical system, an optical sensor, and an emission optical system. The sample processing system is configured to retain a first sample holder and a second sample holder, wherein the number of sample cells is different for each sample holder or a characteristic dimension for the first sample cells is different from that of the second sample holder. The instrument also includes an excitation source temperature controller comprising a temperature sensor that is coupled to the excitation source. The temperature controller is configured to produce a first target temperature when the first sample holder is retained by the instrument and to produce a second target temperature when the second sample holder is retained by the instrument.Type: GrantFiled: February 21, 2020Date of Patent: October 11, 2022Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Mingsong Chen, Mauro Aguanno, Kuan Moon Boo, Woon Liang Terence Soh, Jacob K. Freudenthal, Jeffrey A. Marks
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Patent number: 11339425Abstract: A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lends can be a bi-convex lens.Type: GrantFiled: April 12, 2019Date of Patent: May 24, 2022Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Jacob K. Freudenthal, Geoffrey Dahlhoff, Kevin Maher, Ming Song Chen, Gary Lim, Ronald Danehy, David Fortescue, Ming Shen, Woon Liang Soh, Francis T. Cheng, Ruoyun Wu, Thiam Chye Lee, Gary A. Chappell, Chee Kiong Lim, Jeff Dere, Ted Straub, Jorge Fonseca, Kuan Moon Boo, Soo Yong Lau
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Publication number: 20200191719Abstract: An instrument for processing and/or measuring a biological process contains a sample processing system, an excitation source, an excitation optical system, an optical sensor, and an emission optical system. The sample processing system is configured to retain a first sample holder and a second sample holder, wherein the number of sample cells is different for each sample holder or a characteristic dimension for the first sample cells is different from that of the second sample holder. The instrument also includes an excitation source temperature controller comprising a temperature sensor that is coupled to the excitation source. The temperature controller is configured to produce a first target temperature when the first sample holder is retained by the instrument and to produce a second target temperature when the second sample holder is retained by the instrument.Type: ApplicationFiled: February 21, 2020Publication date: June 18, 2020Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Mingsong CHEN, Mauro AGUANNO, Kuan Moon BOO, Woon Liang Terence SOH, Jacob K. FREUDENTHAL, Jeffrey A. MARKS
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Patent number: 10625258Abstract: Microfluidic devices, assemblies, and systems are provided, as are methods of manipulating micro-sized samples of fluids. Microfluidic devices having a plurality of specialized processing features are also provided.Type: GrantFiled: October 19, 2015Date of Patent: April 21, 2020Assignee: Applied Biosystems, LLCInventors: Sean M. Desmond, Zbigniew T. Bryning, John S. Shigeura, Gary Lim, Adrian Fawcett, Jacob K. Freudenthal, Gary Bordenkircher
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Patent number: 10591416Abstract: An instrument for processing and/or measuring a biological process contains a sample processing system, an excitation source, an excitation optical system, an optical sensor, and an emission optical system. The sample processing system is configured to retain a first sample holder and a second sample holder, wherein the number of sample cells is different for each sample holder or a characteristic dimension for the first sample cells is different from that of the second sample holder. The instrument also includes an excitation source temperature controller comprising a temperature sensor that is coupled to the excitation source. The temperature controller is configured to produce a first target temperature when the first sample holder is retained by the instrument and to produce a second target temperature when the second sample holder is retained by the instrument.Type: GrantFiled: February 24, 2014Date of Patent: March 17, 2020Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Mingsong Chen, Mauro Aguanno, Kuan Moon Boo, Woon Liang Terence Soh, Jacob K. Freudenthal, Jeffrey A. Marks
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Publication number: 20190300936Abstract: A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lends can be a bi-convex lens.Type: ApplicationFiled: April 12, 2019Publication date: October 3, 2019Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Jacob K. FREUDENTHAL, Geoffrey DAHLHOFF, Kevin MAHER, Ming Song CHEN, Gary LIM, Ronald DANEHY, David FORTESCUE, Ming SHEN, Woon Liang Soh, Francis T. CHENG, Ruoyun WU, Thiam Chye LEE, Gary A. CHAPPELL, Chee Kiong LIM, Jeff DERE, Ted E. STRAUB, Jorge FONSECA, Kuan Moon BOO, Soo Yong LAU
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Patent number: 10323274Abstract: A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lens can be a bi-convex lens.Type: GrantFiled: September 28, 2012Date of Patent: June 18, 2019Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Jacob K. Freudenthal, Kevin Maher, Ming Song Chen, Theodore E. Straub, Kuan Moon Boo, Soo Yong Lau
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Publication number: 20170307529Abstract: An instrument for processing and/or measuring a biological process contains an excitation source, a sample holder, an optical sensor, an excitation optical system, and an emission optical system. The sample holder is configured to receive a plurality of biological samples. The optical sensor is configured to receive an emission from the biological samples. The excitation optical system is disposed along an excitation optical path and is configured to direct the electromagnetic radiation from the excitation source to the biological samples. The emission optical system is disposed along an emission optical path and is configured to direct electromagnetic emissions from the biological samples to the optical sensor. The instrument further contains a plurality of filter assemblies configured to be interchangeably located along at least one of the optical paths.Type: ApplicationFiled: July 7, 2017Publication date: October 26, 2017Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Kevin MAHER, Mingsong CHEN, Jacob K. FREUDENTHAL, Kuan Moon BOO, Soo Yong LAU, David FORTESCUE, Ming SHEN, Woon Liang Terence SOH
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Patent number: 9495741Abstract: A method for calibrating a biological instrument is provided. The method comprises the steps of acquiring an image of at least one biological sample array, determining a first region of interest within the image, wherein the first region of interest comprises a first plurality of locations on the at least one biological array; and identifying within the first region of interest, a plurality of image elements associated with each of the first plurality of locations on the at least one biological array.Type: GrantFiled: September 30, 2012Date of Patent: November 15, 2016Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Jacob K. Freudenthal, Jeffrey A. Marks, Francis T. Cheng, Thomas Wessel
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Publication number: 20160107160Abstract: Microfluidic devices, assemblies, and systems are provided, as are methods of manipulating micro-sized samples of fluids. Microfluidic devices having a plurality of specialized processing features are also provided.Type: ApplicationFiled: October 19, 2015Publication date: April 21, 2016Inventors: Sean M. Desmond, Zbigniew T. Bryning, John S. Shigeura, Gary Lim, Adrian Fawcett, Jacob K. Freudenthal, Gary Bordenkircher
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Publication number: 20160011115Abstract: An instrument for processing and/or measuring a biological process contains a sample processing system, an excitation source, an excitation optical system, an optical sensor, and an emission optical system. The sample processing system is configured to retain a first sample holder and a second sample holder, wherein the number of sample cells is different for each sample holder or a characteristic dimension for the first sample cells is different from that of the second sample holder. The instrument also includes an excitation source temperature controller comprising a temperature sensor that is coupled to the excitation source. The temperature controller is configured to produce a first target temperature when the first sample holder is retained by the instrument and to produce a second target temperature when the second sample holder is retained by the instrument.Type: ApplicationFiled: February 24, 2014Publication date: January 14, 2016Inventors: Mingsong CHEN, Mauro AGUANNO, Kuan Moon BOO, Woon Liang Terence SOH, Jacob K. FREUDENTHAL, Jeffrey A. MARKS
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Publication number: 20140294268Abstract: A method for calibrating a biological instrument is provided. The method comprises the steps of acquiring an image of at least one biological sample array, determining a first region of interest within the image, wherein the first region of interest comprises a first plurality of locations on the at least one biological array; and identifying within the first region of interest, a plurality of image elements associated with each of the first plurality of locations on the at least one biological array.Type: ApplicationFiled: September 30, 2012Publication date: October 2, 2014Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Jacob K. Freudenthal, Jeffrey A. Marks, Francis T. Cheng, Thomas Wessel
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Publication number: 20140213487Abstract: A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lens can be a bi-convex lens.Type: ApplicationFiled: September 28, 2012Publication date: July 31, 2014Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Jacob K. Freudenthal, Geoffrey Dahlhoff, Kevin Maher, Ming Song Chen, Gary Lim, Ronald Danehy, David Fortescue, Ming Shen, Woon Liang Soh, Francis T. Cheng, Ruoyun Wu, Thiam Chye Lee, Gary A. Chappell, Chee Kiong Lim, Jeff Dere, Theodore E. Straub, Jorge Fonseca, Kuan Moon Boo, Soo Yong Lau
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Publication number: 20140106364Abstract: Microfluidic devices, assemblies, and systems are provided, as are methods of manipulating micro-sized samples of fluids. Microfluidic devices having a plurality of specialized processing features are also provided.Type: ApplicationFiled: December 20, 2013Publication date: April 17, 2014Applicant: Applied Biosystems, LLCInventors: Sean M. Desmond, Zbigniew T. Bryning, John S. Shigeura, Gary Lim, Adrian Fawcett, Jacob K. Freudenthal, Gary Bordenkircher
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Patent number: 8623296Abstract: Microfluidic devices, assemblies, and systems are provided, as are methods of manipulating micro-sized samples of fluids. Microfluidic devices having a plurality of specialized processing features are also provided.Type: GrantFiled: August 4, 2010Date of Patent: January 7, 2014Assignee: Applied Biosystems, LLCInventors: Sean M. Desmond, Zbigniew T. Bryning, John Shigeura, Gary Lim, Adrian Fawcett, Jacob K. Freudenthal, Gary Bordenkircher
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Publication number: 20100298172Abstract: Microfluidic devices, assemblies, and systems are provided, as are methods of manipulating micro-sized samples of fluids. Microfluidic devices having a plurality of specialized processing features are also provided.Type: ApplicationFiled: August 4, 2010Publication date: November 25, 2010Applicant: Applied Biosystems, LLCInventors: Sean M. DESMOND, Zbigniew T. BRYNING, John SHIGEURA, Gary LIM, Adrian FAWCETT, Jacob K. FREUDENTHAL, Gary BORDENDIRCHER