Patents by Inventor Jacob T. Gilliam
Jacob T. Gilliam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8802932Abstract: Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include amino acid sequences, and variants and fragments thereof, for family members of a novel family of antipathogenic polypeptides. Polynucleotides that encode the antipathogenic polypeptides are also provided. A method for inducing pathogen resistance in a plant using the polynucleotides disclosed herein is further provided. Compositions comprising an antipathogenic polypeptide or a microorganism comprising an antipathogenic polynucleotide of the invention in combination with a carrier and methods of using these compositions to protect a plant from a pathogen are further provided. Plants, plant cells, seeds, and microorganisms comprising an antipathogenic polnucleotide or polypeptide of the invention are also disclosed.Type: GrantFiled: August 9, 2011Date of Patent: August 12, 2014Assignees: Pioneer Hi Bred International Inc, E I Du Pont De Nemours and CompanyInventors: Daniel J. Altier, Jacob T. Gilliam, Eric J. Schepers, Nasser Yalpani
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Publication number: 20120054910Abstract: Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include amino acid sequences, and variants and fragments thereof, for family members of a novel family of antipathogenic polypeptides. Polynucleotides that encode the antipathogenic polypeptides are also provided. A method for inducing pathogen resistance in a plant using the polynucleotides disclosed herein is further provided. Compositions comprising an antipathogenic polypeptide or a microorganism comprising an antipathogenic polynucleotide of the invention in combination with a carrier and methods of using these compositions to protect a plant from a pathogen are further provided. Plants, plant cells, seeds, and microorganisms comprising an antipathogenic polnucleotide or polypeptide of the invention are also disclosed.Type: ApplicationFiled: August 9, 2011Publication date: March 1, 2012Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: Daniel J. Altier, Jacob T. Gilliam, Eric J. Schepers, Nasser Yalpani
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Patent number: 7825294Abstract: Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include an amino acid sequence, and variants and fragments thereof, for an antipathogenic polypeptide that was isolated from a fungal fermentation broth. Nucleic acid molecules that encode the antipathogenic polypeptides of the invention, and antipathogenic domains thereof, are also provided. A method for inducing pathogen resistance in a plant using the nucleotide sequences disclosed herein is further provided. The method comprises introducing into a plant an expression cassette comprising a promoter operably linked to a nucleotide sequence that encodes an antipathogenic polypeptide of the invention. Compositions comprising an antipathogenic polypeptide or a transformed microorganism comprising a nucleic acid of the invention in combination with a carrier and methods of using these compositions to protect a plant from a pathogen are further provided.Type: GrantFiled: July 16, 2009Date of Patent: November 2, 2010Assignees: Pioneer Hi-Bred International, Inc., E.I. du Pont de Nemours and Company, The Regents of the University of CaliforniaInventors: Daniel J. Altier, I. A. Ellanskaya, Jacob T. Gilliam, Jennie Hunter-Cevera, James K Presnail, Eric Schepers, Carl R. Simmons, Tamas Torok, Nasser Yalpani
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Patent number: 7700832Abstract: Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include amino acid sequences, and variants and fragments thereof, for antipathogenic polypeptides that were isolated from fungal fermentation broths. Nucleic acids that encode the antipathogenic polypeptides are also provided. A method for inducing pathogen resistance in a plant using the nucleotide sequences disclosed herein is further provided. The method comprises introducing into a plant an expression cassette comprising a promoter operably linked to a nucleotide sequence that encodes an antipathogenic polypeptide of the invention. Compositions comprising an antipathogenic polypeptide or a transformed microorganism comprising a nucleic acid of the invention in combination with a carrier and methods of using these compositions to protect a plant from a pathogen are further provided.Type: GrantFiled: November 5, 2008Date of Patent: April 20, 2010Assignees: Pioneer Hi-Bred International, Inc., E.I. du Pont de Nemours and Company, The Regents of the University of CaliforniaInventors: Daniel J. Altier, Virginia C. Crane, Irina Ellanskaya, Natalia Ellanskaya, legal representative, Jacob T. Gilliam, Jennie Hunter-Cevera, James K. Presnail, Eric J. Schepers, Carl R. Simmons, Tamas Torok, Nasser Yalpani
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Publication number: 20100031391Abstract: Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include an amino acid sequence, and variants and fragments thereof, for an antipathogenic polypeptide that was isolated from a fungal fermentation broth. Nucleic acid molecules that encode the antipathogenic polypeptides of the invention, and antipathogenic domains thereof, are also provided. A method for inducing pathogen resistance in a plant using the nucleotide sequences disclosed herein is further provided. The method comprises introducing into a plant an expression cassette comprising a promoter operably linked to a nucleotide sequence that encodes an antipathogenic polypeptide of the invention. Compositions comprising an antipathogenic polypeptide or a transformed microorganism comprising a nucleic acid of the invention in combination with a carrier and methods of using these compositions to protect a plant from a pathogen are further provided.Type: ApplicationFiled: July 16, 2009Publication date: February 4, 2010Applicants: Pioneer Hi-Bred International, Inc., E.I. du PONT de NEMOURS and COMPANY, The Regents of The University of CaliforniaInventors: Daniel J. Altier, I.A. Ellanskaya, Jacob T. Gilliam, Jennie Hunter-Cevera, James K. Presnail, Eric Schepers, Carl R. Simmons, Tamas Torok, Nasser Yalpani
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Patent number: 7598346Abstract: The invention relates to compositions including amino acid sequences isolated from fungal fermentation broths and methods for protecting a plant from a pathogen, particularly a fungal pathogen.Type: GrantFiled: May 15, 2007Date of Patent: October 6, 2009Assignees: Pioneer Hi-Bred International, Inc., E. I. du Pont de Nemours and Company, The Regents of the University of CaliforniaInventors: Daniel J. Altier, Virginia C. Crane, Irina Ellanskaya, Natalia Ellanskaya, legal representative, Jacob T. Gilliam, Jennie Hunter-Cevera, James K. Presnail, Eric J. Schepers, Carl R. Simmons, Tamas Torok, Nasser Yalpani
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Patent number: 7589176Abstract: The invention relates to antifungal compositions and methods for protecting a plant from a fungal pathogen. Compositions including antifungal polypeptides isolated from a fungal fermentation broth are provided.Type: GrantFiled: January 24, 2007Date of Patent: September 15, 2009Assignees: Pioneer Hi-Bred International, Inc., E. I. du Pont de Nemours and Company, The Regents of the University of CaliforniaInventors: Daniel J. Altier, Irina Ellanskaya, Natalia Ellanskaya, legal representative, Jacob T. Gilliam, Jennie Hunter-Cevera, James K. Presnail, Eric Schepers, Carl R. Simmons, Tamas Torok, Nasser Yalpani
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Publication number: 20090089895Abstract: Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include amino acid sequences, and variants and fragments thereof, for antipathogenic polypeptides that were isolated from fungal fermentation broths. Nucleic acids that encode the antipathogenic polypeptides are also provided. A method for inducing pathogen resistance in a plant using the nucleotide sequences disclosed herein is further provided. The method comprises introducing into a plant an expression cassette comprising a promoter operably linked to a nucleotide sequence that encodes an antipathogenic polypeptide of the invention. Compositions comprising an antipathogenic polypeptide or a transformed microorganism comprising a nucleic acid of the invention in combination with a carrier and methods of using these compositions to protect a plant from a pathogen are further provided.Type: ApplicationFiled: November 5, 2008Publication date: April 2, 2009Applicants: Pioneer Hi-Bred International, Inc., E.I. du PONT de NEMOURS and COMPANY, The Regents of The University of CaliforniaInventors: Daniel J. Altier, Virginia C. Crane, Irina Ellanskaya, Jacob T. Gilliam, Jennie Hunter-Cevera, James K. Presnail, Eric J. Schepers, Carl R. Simmons, Tamas Torok, Nasser Yalpani, Natalia Ellanskaya
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Patent number: 7241934Abstract: The present invention provides polynucleotides and related polypeptides of the enzyme APAO isolated from Exophiala spinifera and Rhinocladiella atrovirens. The polynucleotides may be mutated to remove glycosylation sites and cysteine residues. Additionally, the present invention provides recombinant expression cassettes, host cells, transgenic plants, and transgenic seed. The present invention also provides for polynucleotides containing both APAO and a fumonisin esterase. In addition, the present invention provides methods for producing the APAO enzyme in both prokaryotic and eukaryotic systems, methods for detecting fumonisins, and methods for identifying transformed plant cells. Methods for degrading fungal toxins in plants, grain, grain processing, silage, food crops and in animal feed are also disclosed.Type: GrantFiled: December 22, 2003Date of Patent: July 10, 2007Assignee: Pioneer Hi-Bred International, Inc.Inventors: Jonathan P. Duvick, Jacob T. Gilliam, Joyce R. Maddox, Aragula Gururaj Rao, Oswald R. Crasta, Otto Folkerts
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Patent number: 6987212Abstract: The present invention provides transformed plants comprising a polynucleotide enconding amino polyol amine oxidase (APAO ) from Exophiala spinifera and a method of expressing APAO transgenic plants and seeds. In this way, transgenic plant can be produced having fumonisin degrading capability, as well as with the capability of producing the degrading enzymes.Type: GrantFiled: July 22, 2003Date of Patent: January 17, 2006Assignees: Pioneer Hi-Bred International, Inc., Curagen CorporationInventors: Jonathan P. Duvick, Jacob T. Gilliam, Joyce R. Maddox, Oswald R. Crasta, Otto Folkerts
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Patent number: 6943279Abstract: The present invention provides polynucleotides and related polypeptides of the enzyme APAO isolated from Exophiala spinifera and Rhinocladiella airovirens. The polynucleotides may be mutated to remove glycosylation sites and cysteine residues. Additionally, the present invention provides recombinant expression cassettes, host cells, transgenic plants, and transgenic seed. The present invention also provides for polynucleotides containing both APAO and a fumonisin esterase. In addition, the present invention provides methods for producing the APAO enzyme in both prokaryotic and eukaryotic systems, methods for detecting fumonisins, and methods for identifying transformed plant cells. Methods for degrading fungal toxins in plants, grain, grain processing, silage, food crops and in animal feed are also disclosed.Type: GrantFiled: September 8, 2000Date of Patent: September 13, 2005Assignee: Pioneer Hi-Bred International, Inc.Inventors: Jonathan P. Duvick, Jacob T. Gilliam, Joyce R. Maddox, Aragula Gururaj Rao, Oswald R. Crasta, Otto Folkerts
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Patent number: 6835569Abstract: The present invention provides polynucleotides and related polypeptides of the enzyme APAO isolated from Exophiala spinifera. Additionally, the polynucleotide encoding for the APAO enzyme can be used to transform plant cells normally susceptible to Fusarium or other toxin-producing fungus infection. Plants can be regenerated from the transformed plant cells. Additionally, the present invention provides for expressing both APAO and a fumonisin esterase in a transgenic plant. In this way, a transgenic plant can be produced with the capability of degrading fumonisin, as well as with the capability of producing the degrading enzymes. In addition, the present invention provides methods for producing the APAO enzyme in both prokaryotic and non-plant eukaryotic systems.Type: GrantFiled: January 26, 2001Date of Patent: December 28, 2004Assignee: Pioneer Hi-Bred International, Inc.Inventors: Jonathan P. Duvick, Jacob T. Gilliam, Joyce R. Maddox, Oswald Crasta, Otto Folkerts
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Patent number: 6812380Abstract: The present invention provides nucleotide sequences encoding zearalenone detoxification polypeptides, and methods for mycotoxin detoxification using the sequences. One method comprises stably incorporating into the genome of a plant cell, a nucleotide sequence of the present invention operably linked to a heterologous promoter and regenerating a stably transformed plant that expresses the nucleotide sequence.Type: GrantFiled: March 26, 2002Date of Patent: November 2, 2004Assignee: Pioneer Hi-Bred International, Inc.Inventors: Petr Karlovsky, Edmund H. Crane, III, Jacob T. Gilliam, Joyce R. Maddox
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Publication number: 20040168212Abstract: The present invention provides polynucleotides and related polypeptides of the enzyme APAO isolated from Exophiala spinifera. Additionally, the polynucleotide encoding for the APAO enzyme can be used to transform plant cells normally susceptible to Fusarium or other toxin-producing fungus infection. Plants can be regenerated from the transformed plant cells. Additionally, the present invention provides for expressing both APAO and a fumonisin esterase in a transgenic plant. In this way, a transgenic plant can be produced with the capability of degrading fumonisin, as well as with the capability of producing the degrading enzymes. In addition, the present invention provides methods for producing the APAO enzyme in both prokaryotic and non-plant eukaryotic systems. Methods for detoxification in grain, grain processing, silage, food crops and in animal feed and rumen microbes are also disclosed.Type: ApplicationFiled: July 22, 2003Publication date: August 26, 2004Applicants: Pioneer Hi-Bred International, Inc., CuraGen Corp.Inventors: Jonathan P. Duvick, Jacob T. Gilliam, Joyce R. Maddox, Oswald R. Crasta, Otto Folkerts
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Patent number: 6737562Abstract: The present invention provides polynucleotides and related polypeptides of the enzyme APAO isolated from Exophiala spinfera and Rhinocladiella atrovirens. Additionally, the polynucleotides encoding for the APAO enzyme can be used to transform plant cells normally susceptible to Fusarium. Plants can be regenerated from the transformed plant cells.Type: GrantFiled: January 26, 2001Date of Patent: May 18, 2004Assignee: Pioneer Hi-Bred International, Inc.Inventors: Jonathan P. Duvick, Jacob T. Gilliam, Joyce R. Maddox
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Patent number: 6670189Abstract: Methods for identifying organisms capable of degrading fumonisin. Fumonisin can be incorporated into culture medium for selection of organisms resistant to fumonisin and/or capable of growing on fumonisin as a sole carbon source. Using this method, several organisms have been identified. These organisms can be used to isolate the enzymes and the genes responsible for conferring fumonisin-resistance. The gene can be cloned and inserted into a suitable expression vector so that the protein can be further characterized. Additionally, the DNA encoding for fumonisin degrading enzymes can be used to transform plant cells normally susceptible to Fusarium or other toxin-producing fungus infection. Plants can be regenerated from the transformed plant cells. In this way, a transgenic plant can be produced with the capability of degrading fumonisin, as well as with the capability of producing the degrading enzymes.Type: GrantFiled: December 5, 2000Date of Patent: December 30, 2003Assignee: Pioneer Hi-Bred International, Inc.Inventors: Jonathan Duvick, Joyce R. Maddox, Tracy A. Rood, Xun Wang, Benjamin A. Bowen, Jacob T. Gilliam
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Publication number: 20030126636Abstract: The present invention provides polynucleotides and related polypeptides of the enzyme APAO isolated from Exophiala spinifera. Additionally, the polynucleotide encoding for the APAO enzyme can be used to transform plant cells normally susceptible to Fusarium or other toxin-producing fungus infection. Plants can be regenerated from the transformed plant cells. Additionally, the present invention provides for expressing both APAO and a fumonisin esterase in a transgenic plant. In this way, a transgenic plant can be produced with the capability of degrading fumonisin, as well as with the capability of producing the degrading enzymes. In addition, the present invention provides methods for producing the APAO enzyme in both prokaryotic and non-plant eukaryotic systems. Methods for detoxification in grain, grain processing, silage, food crops and in animal feed and rumen microbes are also disclosed.Type: ApplicationFiled: January 26, 2001Publication date: July 3, 2003Inventors: Jonathan P. Duvick, Jacob T. Gilliam, Joyce R. Maddox, Oswald R. Crasta, Otto Folkerts
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Publication number: 20030073239Abstract: The present invention provides compositions and methods for detoxification of mycotoxins. Compositions include novel nucleotide sequences encoding zearalenone detoxification polypeptides, and biologically active variants thereof. Further provided are methods for mycotoxin detoxification using the sequences disclosed herein. One method comprises stably incorporating into the genome of a plant cell, a nucleotide sequence of the present invention operably linked to a heterologous promoter and regenerating a stably transformed plant that expresses the nucleotide sequence. An additional method comprises incorporating a nucleotide sequence of the present invention operably linked to a heterologous promoter into a microorganism and applying said microorganism to a plant or grain.Type: ApplicationFiled: March 26, 2002Publication date: April 17, 2003Applicant: Pioneer Hi-Bred International, Inc.Inventors: Petr Karlovsky, Edmund H. Crane, Jacob T. Gilliam, Joyce R. Maddox
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Patent number: 6211435Abstract: The present invention provides polynucleotides and related polypeptides of the enzyme APAO isolated from Exophiala spinifera. Additionally, the polynucleotide encoding for the APAO enzyme can be used to transform plant cells normally susceptible to Fusarium or other toxin-producing fungus infection. Plants can be regenerated from the transformed plant cells. Additionally, the present invention provides for expressing both APAO and a fumonisin esterase in a transgenic plant. In this way, a transgenic plant can be produced with the capability of degrading fumonisin, as well as with the capability of producing the degrading enzymes. In addition, the present invention provides methods for producing the APAO enzyme in both prokaryotic and non-plant eukaryotic systems. Methods for detoxification in grain, grain processing, silage, food crops and in animal feed and rumen microbes are also disclosed.Type: GrantFiled: July 12, 1999Date of Patent: April 3, 2001Assignees: Pioneer Hi-Bred International, Inc., CuraGen CorporationInventors: Jonathan P. Duvick, Jacob T. Gilliam, Joyce R. Maddox, Oswald R. Crasta, Otto Folkerts
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Patent number: 6211434Abstract: The present invention provides polynucleotides and related polypeptides of the enzyme APAO isolated from Exophiala spinifera and Rhinocladiella atrovirens. Additionally, the polynucleotides encoding for the APAO enzyme can be used to transform plant cells normally susceptible to Fusarium or other toxin-producing fungus infection. Plants can be regenerated from the transformed plant cells. Additionally, the present invention provides for expressing both APAO and a fumonisin esterase in a transgenic plant. In this way, a transgenic plant can be produced with the capability of degrading fumonisin, as well as with the capability of producing the degrading enzymes. In addition, the present invention provides methods for producing the APAO enzyme in both prokaryotic and non-plant eukaryotic systems. Methods for detoxification in grain, grain processing, silage, food crops and in animal feed and rumen microbes are also disclosed.Type: GrantFiled: July 12, 1999Date of Patent: April 3, 2001Assignee: Pioneer Hi-Bred International, Inc.Inventors: Jonathan P. Duvick, Jacob T. Gilliam, Joyce R. Maddox