Patents by Inventor Jacob Vincent Micallef

Jacob Vincent Micallef has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR THE DETECTION OF LUNG CANCER
    Publication number: 20240077487
    Abstract: The invention relates to methods and uses of a panel of biomarkers in a body fluid sample for diagnosing and/or monitoring lung cancer, in particular early stage lung cancer. The biomarkers include particular histone modifications present on cell free nucleosomes, in combination with Carcinoembryonic Antigen (CEA).
    Type: Application
    Filed: January 13, 2022
    Publication date: March 7, 2024
    Inventors: Marielle HERZOG, Jacob Vincent MICALLEF
  • DIAGNOSTIC METHOD FOR MULTIPLE SCLEROSIS
    Publication number: 20240019432
    Abstract: The invention relates methods for diagnosing patients with multiple sclerosis by detecting cell free nucleosomes as biomarkers in body fluid samples.
    Type: Application
    Filed: December 8, 2021
    Publication date: January 18, 2024
    Inventors: Jason Bradley TERRELL, Jacob Vincent MICALLEF, Mark Edward ECCLESTON, Marielle HERZOG
  • DEVICE FOR INLINE MONITORING OF FREE NUCLEOSOMES IN BLOOD
    Publication number: 20230355851
    Abstract: The present invention relates to an extracorporeal device or an ex vivo organ perfusion device comprising an inline monitoring method or device for measuring cell free nucleosomes, particularly an apheresis device comprising a monitoring method or device for measuring cell free nucleosomes in the blood of a subject.
    Type: Application
    Filed: September 21, 2021
    Publication date: November 9, 2023
    Inventor: Jacob Vincent Micallef
  • TRIAGING METHOD USING CELL FREE NUCLEOSOME LEVELS
    Publication number: 20230204599
    Abstract: The invention relates to using cell free nucleosome levels to identify patients at risk of developing a NETosis associated adverse reaction to the infection. The methods are used to monitor the progress of a disease and assigning a risk of an adverse outcome in a patient suffering from an infection.
    Type: Application
    Filed: March 19, 2021
    Publication date: June 29, 2023
    Inventors: Jacob Vincent MICALLEF, Mark Edward ECCLESTON, Jason Bradley TERRELL
  • METHOD FOR DETECTING NUCLEOSOMES CONTAINING HISTONE VARIANTS
    Publication number: 20230116530
    Abstract: The invention relates to a method for detecting and measuring the presence of mono-nucleosomes and oligo-nucleosomes and nucleosomes that contain particular histone variants and the use of such measurements for the detection and diagnosis of disease. The invention also relates to a method of identifying histone variant biomarkers for the detection and diagnosis of disease and to biomarkers identified by said method.
    Type: Application
    Filed: December 6, 2022
    Publication date: April 13, 2023
    Inventor: Jacob Vincent Micallef
  • TRIAGING METHOD USING CELL FREE NUCLEOSOME LEVELS
    Publication number: 20230051905
    Abstract: The invention relates to using cell free nucleosome levels to identify patients at risk of developing a NETosis associated adverse reaction to the infection. The methods are used to monitor the progress of a disease and assigning a risk of an adverse outcome in a patient suffering from an infection.
    Type: Application
    Filed: August 25, 2022
    Publication date: February 16, 2023
    Inventors: Jacob Vincent MICALLEF, Mark Edward ECCLESTON, Jason Bradley TERRELL
  • USE OF CELL FREE NUCLEOSOMES AS BIOMARKERS
    Publication number: 20230003735
    Abstract: The invention relates to cell free nucleosomes as biomarkers in plasma samples for vascular or haematological cancers.
    Type: Application
    Filed: December 2, 2020
    Publication date: January 5, 2023
    Inventors: Jacob Vincent MICALLEF, Heather WILSON-ROBLES, Mark Edward ECCLESTON, Marielle Chantal Andree HERZOG, Jason Bradley TERRELL
  • METHOD FOR THE ENRICHMENT OF CIRCULATING TUMOR DNA
    Publication number: 20220334128
    Abstract: The invention relates to the use of histone binding agents for detecting, isolating and/or purifying cell free nucleosomes of tumor origin or circulating tumor DNA from a biological sample. The invention also relates to methods and kits using said histone binding agents.
    Type: Application
    Filed: June 7, 2022
    Publication date: October 20, 2022
    Inventors: Jacob Vincent MICALLEF, Marielle HERZOG, Mark Edward ECCLESTON
  • METHOD FOR THE DETECTION OF PROSTATE CANCER
    Publication number: 20220291221
    Abstract: The invention relates to a body fluid test method for the detection and treatment of prostate cancer, in particular aggressive prostate cancer. It also relates to monitoring of patients with low risk prostate tumours and selection of patients for prostate biopsy as well as selection of patients for prostate surgery or therapy.
    Type: Application
    Filed: May 1, 2020
    Publication date: September 15, 2022
    Inventors: Jacob Vincent MICALLEF, Mark Edward ECCLESTON, Marielle HERZOG, Jason Bradley TERRELL
  • METHOD OF ISOLATING CIRCULATING NUCLEOSOMES
    Publication number: 20220290252
    Abstract: The invention relates to methods for separating circulating cell free nucleosomes comprising linker DNA from a biological fluid sample, in particular nucleosomes of disease origin. Such methods allow for improved analysis of genetic and epigenetic markers associated with nucleosomes of disease origin.
    Type: Application
    Filed: August 27, 2020
    Publication date: September 15, 2022
    Inventors: Mark Edward ECCLESTON, Jacob Vincent MICALLEF
  • METHOD FOR THE DETECTION OF CANCER
    Publication number: 20220221470
    Abstract: The invention relates to body fluid test methods for the detection of cancer using a combination biomarker panel comprising at least one cytokine molecule and at least one cell free chromatin fragment.
    Type: Application
    Filed: May 1, 2020
    Publication date: July 14, 2022
    Inventors: Jacob Vincent MICALLEF, Mark Edward ECCLESTON, Marielle HERZOG, Jason Bradley TERRELL
  • Method for detecting nucleosome adducts
    Patent number: 11193939
    Abstract: The invention relates to a method for detecting and measuring the presence of nucleosome-protein adducts and the use of such measurements for the detection and diagnosis of disease. The invention also relates to a method of identifying nucleosome adduct biomarkers for the detection and diagnosis of disease and to biomarkers identified by said method.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: December 7, 2021
    Assignee: Belgian Volition SPRL
    Inventors: Jacob Vincent Micallef, Mark Edward Eccleston, Marielle Herzog
  • Method for detecting nucleosomes containing nucleotides
    Patent number: 10900064
    Abstract: The invention relates to a method for detecting and measuring the presence of mono-nucleosomes and oligo-nucleosomes and nucleosomes that contain particular nucleotides and the use of such measurements for the detection and diagnosis of disease. The invention also relates to a method of identifying nucleosome associated nucleotide biomarkers for the detection and diagnosis of disease and to biomarkers identified by said method.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: January 26, 2021
    Assignee: Belgian Volition SPRL
    Inventor: Jacob Vincent Micallef
  • USE OF NUCLEOSOME-TRANSCRIPTION FACTOR COMPLEXES FOR CANCER DETECTION
    Publication number: 20200363418
    Abstract: The invention relates to the use of tissue specific transcription factor-nucleosome adducts or transcription cofactor-nucleosome adducts as biomarkers in a biological fluid for the detection or diagnosis of a cancer in a subject. The invention further relates to using said tissue specific transcription factor or cofactor adducts to identify the site of development of a cancer in a subject.
    Type: Application
    Filed: March 22, 2017
    Publication date: November 19, 2020
    Applicant: Belgian Volition SPRL
    Inventors: Jacob Vincent Micallef, Jorge REIS-FILHO
  • METHOD FOR DETECTING NUCLEOSOMES CONTAINING NUCLEOTIDES
    Publication number: 20200347435
    Abstract: The invention relates to a method for detecting and measuring the presence of mono-nucleosomes and oligo-nucleosomes and nucleosomes that contain particular nucleotides and the use of such measurements for the detection and diagnosis of disease. The invention also relates to a method of identifying nucleosome associated nucleotide biomarkers for the detection and diagnosis of disease and to biomarkers identified by said method.
    Type: Application
    Filed: May 15, 2020
    Publication date: November 5, 2020
    Inventor: Jacob Vincent Micallef
  • METHOD FOR DETECTING NUCLEOSOMES CONTAINING HISTONE VARIANTS
    Publication number: 20200341006
    Abstract: The invention relates to a method for detecting and measuring the presence of mono-nucleosomes and oligo-nucleosomes and nucleosomes that contain particular histone variants and the use of such measurements for the detection and diagnosis of disease. The invention also relates to a method of identifying histone variant biomarkers for the detection and diagnosis of disease and to biomarkers identified by said method.
    Type: Application
    Filed: July 9, 2020
    Publication date: October 29, 2020
    Inventor: Jacob Vincent Micallef
  • METHOD FOR THE ENRICHMENT OF CELL FREE NUCLEOSOMES
    Publication number: 20200340997
    Abstract: The present invention relates to the use of a histone H1 binding agent for detecting, isolating and/or purifying cell free nucleosomes of tumor origin from a biological sample. The invention also describes methods of negative or positive selection using histone H1 binding agents, in order to enrich a sample for cell free nucleosomes of tumor origin.
    Type: Application
    Filed: July 14, 2020
    Publication date: October 29, 2020
    Inventors: Mark Edward Eccleston, Jacob Vincent Micallef
  • Method for detecting nucleosomes containing histone modifications and variants
    Patent number: 10768182
    Abstract: The present invention relates to a method for detecting and measuring the presence of cell free mono-nucleosomes and oligo-nucleosomes that contain histone H1 or a histone H1 modification, variant or isoform, and the use of such measurements for the detection and diagnosis of disease.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: September 8, 2020
    Assignee: Belgian Volition SPRL
    Inventors: Mark Edward Eccleston, Jacob Vincent Micallef
  • Method for the enrichment of cell free nucleosomes
    Patent number: 10746746
    Abstract: The present invention relates to the use of a histone H1 binding agent for detecting, isolating and/or purifying cell free nucleosomes of tumor origin from a biological sample. The invention also describes methods of negative or positive selection using histone H1 binding agents, in order to enrich a sample for cell free nucleosomes of tumor origin.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: August 18, 2020
    Assignee: Belgian Volition SPRL
    Inventors: Mark Edward Eccleston, Jacob Vincent Micallef
  • COMBINATION TEST FOR COLORECTAL CANCER
    Publication number: 20200182875
    Abstract: The present invention relates to methods of detecting and/or screening for colorectal cancer (CRC), a colorectal adenoma or a polyp in a patient comprising identifying patients found to be positive for fecal occult blood and further testing for one or more additional factors. Said methods can be used to assess the suitability of a patient for colonoscopy.
    Type: Application
    Filed: July 25, 2017
    Publication date: June 11, 2020
    Applicant: Belgian Volition SPRL
    Inventors: Jacob Vincent Micallef, Jason Terrell