Patents by Inventor Jacobus Theodorus Henricus Van Eupen

Jacobus Theodorus Henricus Van Eupen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical composition comprising amorphous lenalidomide
    Patent number: 10471156
    Abstract: The present invention relates to a pharmaceutical composition comprising an inclusion complex of amorphous lenalidomide, or a pharmaceutically acceptable salt thereof, in non-substituted ?-cyclodextrin and one or more pharmaceutically acceptable excipients. The invention further relates to the use of said composition as a medicament, particularly in the treatment of in the treatment of multiple myeloma and myelodysplastic syndromes.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: November 12, 2019
    Assignee: Synthon B.V.
    Inventors: Rolf Keltjens, Jacobus Theodorus Henricus Van Eupen, Deepak Murpani, Marta Vivancos Martinez, Lisardo Alvarez Fernandez, Luis Nogueiras Nieto
  • Stable pemetrexed arginine salt and compositions comprising it
    Patent number: 10253031
    Abstract: The present invention relates to arginine salt of pemetrexed of formula (1), particularly to a stable solid form thereof, and to pharmaceutical compositions comprising such salt.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: April 9, 2019
    Assignee: Synthon B.V.
    Inventors: Jacobus Theodorus Henricus Van Eupen, Borek Zaludek
  • STABLE PEMETREXED ARGININE SALT AND COMPOSITIONS COMPRISING IT
    Publication number: 20180298014
    Abstract: The present invention relates to arginine salt of pemetrexed of formula (1), particularly to a stable solid form thereof, and to pharmaceutical compositions comprising such salt.
    Type: Application
    Filed: May 25, 2018
    Publication date: October 18, 2018
    Inventors: Jacobus Theodorus Henricus VAN EUPEN, Borek ZALUDEK
  • Pharmaceutical Composition Comprising Amorphous Lenalidomide
    Publication number: 20170368197
    Abstract: The present invention relates to a pharmaceutical composition comprising an inclusion complex of amorphous lenalidomide, or a pharmaceutically acceptable salt thereof, in non-substituted ?-cyclodextrin and one or more pharmaceutically acceptable excipients. The invention further relates to the use of said composition as a medicament, particularly in the treatment of in the treatment of multiple myeloma and myelodyplastic syndromes.
    Type: Application
    Filed: December 16, 2015
    Publication date: December 28, 2017
    Inventors: Rolf KELTJENS, Jacobus Theodorus Henricus VAN EUPEN, Deepak MURPANI, Marta VIVANCOS MARTINEZ, Lisardo ALVAREZ FERNANDEZ, Luis NOGUEIRAS NIETO
  • Lenalidomide salts
    Patent number: 8686153
    Abstract: The present invention relates to acid addition salts of lenalidomide, wherein said acid has a pKa lower than 1, preferably selected from hydrochloric acid, hydrobromic acid, methane sulfonic acid, ethane sulfonic acid, benzene sulfonic acid and p-toluenesulfonic acid, to processes for their making, and use in medicine, and to purification of lenalidomide base.
    Type: Grant
    Filed: August 12, 2009
    Date of Patent: April 1, 2014
    Assignee: Synthon B.V.
    Inventor: Jacobus Theodorus Henricus Van Eupen
  • LENALIDOMIDE SALTS
    Publication number: 20120190711
    Abstract: The present invention relates to acid addition salts of lenalidomide, wherein said acid has a pKa lower than 1, preferably selected from hydrochloric acid, hydrobromic acid, methane sulfonic acid, ethane sulfonic acid, benzene sulfonic acid and p-toluenesulfonic acid, to processes for their making, and use in medicine, and to purification of lenalidomide base.
    Type: Application
    Filed: August 12, 2008
    Publication date: July 26, 2012
    Inventor: Jacobus Theodorus Henricus Van Eupen