Abstract: Provided herein are compounds of Formula (I), their pharmaceutically acceptable salts, and their pharmaceutical compositions: wherein R1, R2, R3a, R3b, R4, R5, and A are defined in the present disclosure. The compounds are potent inhibitors of the main protease (Mpro) of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), and they are useful in treating or preventing COVID-19 in a subject.

Abstract: Methods and systems for providing a secure healthcare communication exchange platform. The methods and systems perform operations comprising: accessing a collection of data records from a plurality of sources, the collection of data records corresponding to a given entity; generating, based on the collection of data records, an aggregated representation of one or more conditions associated with the given entity; determining, based on the aggregated representation, that a given condition of the one or more conditions satisfies an outreach parameter; in response to determining that the given condition satisfies the outreach parameter, triggering an outreach event to communicate with the given entity; generating status information in the aggregated representation, the status information corresponding to the outreach event; and tracking the status information to establish a relationship between the given condition and the outreach parameter.

Abstract: A computer implemented method, data processing system, and computer program product for monitoring system events and providing real-time response to security threats. System data is collected by monitors in the computing system. The expert system of the present invention compares the data against information in a knowledge base to identify a security threat to a system resource in a form of a system event and an action for mitigating effects of the system event. A determination is made as to whether a threat risk value of the system event is greater than an action risk value of the action for mitigating the system event. If the threat risk value is greater, a determination is made as to whether a trust value set by a user is greater than the action risk value. If the trust value is greater, the expert system executes the action against the security threat.

Abstract: Airway monitoring apparatus 30 includes a driver 6 for applying sound in the audible frequency range to the airway of a subject and a detector 7 for monitoring the response of the airway, e.g. by detecting transmitted sound signal components and/or reflected sound signal components. Variations in the detected sound signal, e.g. energy, due to attenuation of the signal, give an indication of the state of the airway, e.g. airway patency, and can be used to monitor sleep-disordered breathing events, such as apnea and hypopnea, and to provide a breathing event index, e.g. AHI. The apparatus may provide servo-control for a respiratory assist device, such as a positive airway pressure device, so as to provide an appropriate pressure level setting. It may allow for home use of such devices and for home titration. It may also assist in discriminating central and obstructive breathing events, and in providing a measure of airway resistance.