Patents by Inventor Jacques P. Dumas

Jacques P. Dumas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TETRACYCLINE COMPOUNDS AND METHODS OF TREATMENT
    Publication number: 20230031954
    Abstract: The present invention is directed to methods of treating hematological cancers, such as acute myleiod leukemia, with tetracyclines, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: August 30, 2017
    Publication date: February 2, 2023
    Inventors: Xiao-Yi Xiao, Jacques P. Dumas, Diana K. Hunt, Cuixiang Sun, Peng Zhao
  • SUBSTITUTED PYRIDINES AND PYRIDAZINES WITH ANGIOGENESIS INHIBITING ACTIVITY
    Publication number: 20110263597
    Abstract: Methods of treating a mammal having a condition characterized by abnormal angiogenesis or hyperpermiability processes using substituted pyridazines having angiogenesis inhibiting activity and the generalized structural formula wherein the ring containing A, B, D, E, and L is phenyl or a nitrogen-containing heterocycle; groups X and Y may be any of a variety of defined linking units; R1 and R2 may be defined independent substituents or together may be a ring-defining bridge; ring J may be an aryl, pyridyl, or cycloalkyl group; and G groups may be any of a variety of defined substituents.
    Type: Application
    Filed: July 7, 2011
    Publication date: October 27, 2011
    Applicant: Bayer HealthCare LLC
    Inventors: Jacques P. Dumas, Stephen James Boyer, Julie A. Dixon, Teddy Kite Joe, Harold C. E. Kluender, Wendy Lee, Dhanapalan Nagarathnam, Robert N. Sibley, Ning Su
  • Substituted pyridines and pyridazines with angiogenesis inhibiting activity
    Patent number: 7977333
    Abstract: Substituted and pyridines and pyridazines having angiogenesis inhibiting activity and the generalized structural formula wherein the ring containing A, B, D, E, and L is phenyl or a nitrogen-containing heterocycle; groups X and Y may be any of a variety of defined linking units; R1 and R2 may be defined independent substituents or together may be a ring-defining bridge; ring J may be an aryl, pyridyl, or cycloalkyl group; and G groups may be any of a variety of defined substituents. Pharmaceutical compositions containing these materials, and methods of treating a mammal having a condition characterized by abnormal angiogenesis or hyperpermiability processes using these materials are also disclosed.
    Type: Grant
    Filed: November 24, 2003
    Date of Patent: July 12, 2011
    Assignee: Bayer Healthcare LLC
    Inventors: Jacques P. Dumas, Stephen J. Boyer, Julie A. Dixon, Teddy K. Joe, Harold C. E. Kluender, Wendy Lee, Dhanapalan Nagarathnam, Robert N. Sibley, Ning Su
  • Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders
    Patent number: 7585888
    Abstract: This invention relates to novel benzofuran and benzothiophene derivatives of the general formula and their use for the treatment of hyper-proliferative disorders.
    Type: Grant
    Filed: March 31, 2008
    Date of Patent: September 8, 2009
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Chengzhi Zhang, Michael J. Burke, Zhi Chen, Jacques P. Dumas, Dongping Fan, Jianmei Fan, Holia Hatoum-Mokdad, Benjamin D. Jones, Gaetan Ladouceur, Wendy Lee, Barton Phillips
  • Substituted phenylamino-benzene derivatives useful for treating hyper-proliferative disorders and diseases associated with mitogen extracellular kinase activity
    Publication number: 20090082328
    Abstract: This invention relates to novel substituted phenylamino-benzene compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: May 9, 2008
    Publication date: March 26, 2009
    Inventors: Yingfu Li, Joachim Rudolph, Jacques P. Dumas, Daniel Auclair, Mario Lobell, Marion Hitchcock, Ingo Hartung, Marcus Koppitz, Dominic Brittain, Florian Puehler, Kirstin Petersen, Judith Guenther
  • Substituted pyridazines and fused pyridazines with angiogenesis inhibiting activity
    Patent number: 6903101
    Abstract: Substituted and Fused pyridazines having angiogenesis inhibiting activity and the generalized structural formula wherein the ring containing A, B, D, E, and L is a nitrogen-containing heterocycle; groups X and Y may be any of a variety of defined linking units; R1 and R2 may be defined independent substituents or together may be a ring-defining bridge; ring J may be an aryl, pyridyl, or cycloalkyl group; and G groups may be any of a variety of defined substituents. Pharmaceutical compositions containing these materials, and methods of treating a mammal having a condition characterized by abnormal angiogenesis or hyperpermiability processes using these materials are also disclosed.
    Type: Grant
    Filed: August 10, 2000
    Date of Patent: June 7, 2005
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Jacques P. Dumas, Stephen James Boyer, Teddy Kite Joe, Holia N. Hatoum-Mokdad, Harold C. E. Kluender, Wendy Lee, Dhanapalan Nagarathnam, Robert N. Sibley, Ning Su
  • Substituted indoles, pharmaceutical compounds containing such indoles and their use as PPAR-&ggr; binding agents
    Patent number: 6787651
    Abstract: Disclosed are substituted indoles, pharmaceutical compositions containing such indoles, and their use in treating or preventing PPAR-&ggr; mediated diseases or conditions, such as osteopenia, osteoporosis, cancer, diabetes and atherosclerosis.
    Type: Grant
    Filed: October 9, 2001
    Date of Patent: September 7, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Andreas Stolle, Jacques P. Dumas, William Carley, Philip D. G. Coish, Steven R. Magnuson, Yamin Wang, Dhanapalan Nagarathnam, Derek B. Lowe, Ning Su, William H. Bullock, Ann-Marie Campbell, Ning Qi, Jeremy L. Baryza, James H. Cook
  • Substituted pyridines and pyridazines with angiogenesis inhibiting activity
    Publication number: 20040092740
    Abstract: Substituted and pyridines and pyridazines having angiogenesis inhibiting activity and the generalized structural formula 1
    Type: Application
    Filed: November 24, 2003
    Publication date: May 13, 2004
    Applicant: Bayer Pharmaceuticals Corporation
    Inventors: Jacques P. Dumas, Stephen James Boyer, Julie A. Dixon, Teddy Kite Joe, Harold C. E. Kluender, Wendy Lee, Dhanapalan Nagarathnam, Robert N. Sibley, Ning Su
  • Substituted pyridines and pyridazines with angiogenesis inhibiting activity
    Patent number: 6689883
    Abstract: Substituted pyridazines having angiogenesis inhibiting activity and the generalized structural formula wherein the ring containing A, B, D, E, and L is phenyl or a nitrogen-containing heterocycle; groups X and Y may be any of a variety of defined linking units; R1 and R2 may be defined independent substituents or together may be a ring-defining bridge; ring J may be an aryl, pyridyl, or cycloalkyl group; and G groups may be any of a variety of defined substituents. Pharmaceutical compositions containing these materials, and methods of treating a mammal having a condition characterized by abnormal angiogenesis or hyperpermiability processes using these materials are also disclosed.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: February 10, 2004
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Jacques P. Dumas, Stephen James Boyer, Julie A. Dixon, Teddy Kite Joe, Harold C. E. Kluender, Wendy Lee, Dhanapalan Nagarathnam, Robert N. Sibley, Ning Su
  • Substituted indoles, pharmaceutical compounds containing such indoles and their use as PPAR-gamma binding agents
    Publication number: 20030087902
    Abstract: Disclosed are substituted indoles, pharmaceutical compositions containing such indoles, and their use in treating or preventing PPAR-&ggr; mediated diseases or conditions, such as osteopenia, osteoporosis, cancer, diabetes and atherosclerosis.
    Type: Application
    Filed: October 9, 2001
    Publication date: May 8, 2003
    Inventors: Andreas Stolle, Jacques P. Dumas, William Carley, Philip D.G. Coish, Steven R. Magnuson, Yamin Wang, Dhanapalan Nagarathnam, Derek B. Lowe, Ning Su, William H. Bullock, Ann-Marie Campbell, Ning Qi, Jeremy L. Baryza, James H. Cook