Abstract: An anchoring system includes an anchor including an anchor body and a distal member located at a distal end of the anchor body, the distal member having a suture receiving aperture; and an implant delivery device, comprising: a cannulated outer shaft, the cannulated outer shaft configured to engage a proximal end of the anchor body for driving the anchor into a bore; and an inner shaft slidably received in the cannulated outer shaft, wherein a distal end of the inner shaft is extendable distally beyond a distal end section of the cannulated outer shaft such that, when the cannulated outer shaft is engaging the proximal end of the anchor body, the distal end of the inner shaft is extendable through the anchor body to a distance beyond the distal end of the anchor body to engage a suture located within the suture receiving aperture, wherein the anchoring system is configured such that the suture can be tensioned at a location within the bore distal from the anchor body before the anchor body is implanted within

Abstract: Methods and compositions generating and using an interleukin-1 receptor antagonist (IL-1ra)-rich solution. Methods for generating and isolating interleukin-1 receptor antagonist include incubating a liquid volume of white blood cells and platelets with polyacrylamide beads to produce interleukin-1 receptor antagonist. The interleukin-1 receptor antagonist is isolated from the polyacrylamide beads to obtain the solution rich in interleukin-1 receptor antagonist. Methods for treating a site of inflammation in a patient include administering to the site of inflammation the solution rich in interleukin-1 receptor antagonist.

Abstract: An anchoring system includes an anchor including an anchor body and a distal member located at a distal end of the anchor body, the distal member having a suture receiving aperture; and an implant delivery device, comprising: a cannulated outer shaft, the cannulated outer shaft configured to engage a proximal end of the anchor body for driving the anchor into a bore; and an inner shaft slidably received in the cannulated outer shaft, wherein a distal end of the inner shaft is extendable distally beyond a distal end section of the cannulated outer shaft such that, when the cannulated outer shaft is engaging the proximal end of the anchor body, the distal end of the inner shaft is extendable through the anchor body to a distance beyond the distal end of the anchor body to engage a suture located within the suture receiving aperture, wherein the anchoring system is configured such that the suture can be tensioned at a location within the bore distal from the anchor body before the anchor body is implanted within

Abstract: An anchoring system includes an anchor including an anchor body and a distal member located at a distal end of the anchor body, the distal member having a suture receiving aperture; and an implant delivery device, comprising: a cannulated outer shaft, the cannulated outer shaft configured to engage a proximal end of the anchor body for driving the anchor into a bore; and an inner shaft slidably received in the cannulated outer shaft, wherein a distal end of the inner shaft is extendable distally beyond a distal end section of the cannulated outer shaft such that, when the cannulated outer shaft is engaging the proximal end of the anchor body, the distal end of the inner shaft is extendable through the anchor body to a distance beyond the distal end of the anchor body to engage a suture located within the suture receiving aperture, wherein the anchoring system is configured such that the suture can be tensioned at a location within the bore distal from the anchor body before the anchor body is implanted within

Abstract: An anchoring system can use an implant delivery device to deploy an implant into a pre-drilled bore, to secure one or more sutures between a threaded outer surface of an implant body and a wall of the bore. The implant delivery device can controllably rotate the implant about its longitudinal axis. The implant delivery device can include a projection extending distally from a distal end of an inner shaft. The implant delivery device can controllably translate a wire between a distally extended position, at which the wire can form a closed loop with the projection and a distal end of the inner shaft, and a proximally retracted position, at which the wire can be at least partially retracted into the distal end of the inner shaft.

Abstract: An anchoring system can use an implant delivery device to deploy an implant into a pre-drilled bore, to secure one or more sutures between a threaded outer surface of an implant body and a wall of the bore. The implant delivery device can controllably rotate the implant about its longitudinal axis. The implant can further include a distal member positioned distal to the implant body and freely rotatable about the longitudinal axis. The implant delivery device can include a finger extending distally from a distal end of an inner shaft. The implant delivery device can controllably translate a wire between a distally extended position, at which the wire can form a closed loop with the finger and a distal end of the inner shaft, and a proximally retracted position, at which the wire can be at least partially retracted into the distal end of the inner shaft.

Abstract: A method and apparatus for securing a suture to bone can include grasping a first suture portion with a grasping member on a positioning tool. The first suture portion can be located into a first cannulation defined in the positioning tool. A cutting member can be advanced through a second cannulation defined on the positioning tool and out through a distal opening defined on the positioning tool. A first bone hole can be cut into the bone with the cutting member. A flexible member advancing tool can be advanced through the first cannulation. The first suture portion can be urged out of the distal opening and into the first bone hole.

Abstract: An anchoring system can use an implant delivery device to deploy an implant into a pre-drilled bore, to secure one or more sutures between a threaded outer surface of an implant body and a wall of the bore. The implant delivery device can controllably rotate the implant about its longitudinal axis. The implant can further include a distal member positioned distal to the implant body and freely rotatable about the longitudinal axis. The implant delivery device can include a finger extending distally from a distal end of an inner shaft. The implant delivery device can controllably translate a wire between a distally extended position, at which the wire can form a closed loop with the finger and a distal end of the inner shaft, and a proximally retracted position, at which the wire can be at least partially retracted into the distal end of the inner shaft.

Abstract: An implant configured for fusing a first bone segment and a second bone segment during an operative procedure and constructed in accordance to one example of the present disclosure includes an implant body, a first bone interfacing portion and a second bone interfacing portion. The implant body can extend longitudinally between an insertion end and an opposite end. The first bone interfacing portion can be provided on the implant body and be configured to be implanted relative to the first bone segment. The second bone interfacing portion can be provided on the implant body and be configured to be implanted relative to the second bone segment. The first and second bone interfacing portions can be inserted dorsally into the first and second bone segments, respectively.

Abstract: An implant having a porous portion with a plurality of interconnected voids for receiving at least one injectable substance such that an injectable substance can elute from the porous portion. A syringe can be inserted into the at least one porous portion for administering the at least one injectable substance into the voids of the porous structure. The implant can be implanted with the at least one porous portion pre-loaded with the at least one injectable substance. The at least one porous portion can be loaded by inserting the syringe into the at least one porous portion after implanting the implant. The porous portion can be re-loaded with the syringe after the at least one injectable substance has eluted from the porous portion or replaced with a different injectable substance.

Abstract: A system and method for remote manufacturing of medical devices are provided. The system can be installed at a facility (e.g., at a hospital or other medical facility), and includes a remote manufacturing unit (RMU) that allows for customized, rapid fabrication of medical devices at the medical facility using suitable manufacturing techniques such as three-dimensional (3D) printing, additive manufacturing, subtractive manufacturing, etc. The RMU can communicate with a computer system which presents a healthcare professional with a digital catalog of medical products, and allows the healthcare professional to select and customize a desired device to be manufactured at the facility.

Abstract: An anchoring system can use an implant delivery device to deploy an implant into a pre-drilled bore, to secure one or more sutures between a threaded outer surface of an implant body and a wall of the bore. The implant delivery device can controllably rotate the implant about its longitudinal axis. The implant delivery device can include a projection extending distally from a distal end of an inner shaft The implant delivery device can controllably translate a wire between a distally extended position, at which the wire can form a closed loop with the projection and a distal end of the inner shaft, and a proximally retracted position, at which the wire can be at least partially retracted into the distal end of the inner shaft.

Abstract: Methods and compositions generating and using an interleukin-1 receptor antagonist (IL-1ra)-rich solution. Methods for generating and isolating interleukin-1 receptor antagonist include incubating a liquid volume of white blood cells and platelets with polyacrylamide beads to produce interleukin-1 receptor antagonist. The interleukin-1 receptor antagonist is isolated from the polyacrylamide beads to obtain the solution rich in interleukin-1 receptor antagonist. Methods for treating a site of inflammation in a patient include administering to the site of inflammation the solution rich in interleukin-1 receptor antagonist.

Abstract: Methods and compositions generating and using an interleukin-1 receptor antagonist (IL-1ra)-rich solution. Methods for generating and isolating interleukin-1 receptor antagonist include incubating a liquid volume of white blood cells and platelets with polyacrylamide beads to produce interleukin-1 receptor antagonist. The interleukin-1 receptor antagonist is isolated from the polyacrylamide beads to obtain the solution rich in interleukin-1 receptor antagonist. Methods for treating a site of inflammation in a patient include administering to the site of inflammation the solution rich in interleukin-1 receptor antagonist.

Abstract: An anchoring system includes an anchor including an anchor body and a distal member located at a distal end of the anchor body, the distal member having a suture receiving aperture; and an implant delivery device, comprising: a cannulated outer shaft, the cannulated outer shaft configured to engage a proximal end of the anchor body for driving the anchor into a bore; and an inner shaft slidably received in the cannulated outer shaft, wherein a distal end of the inner shaft is extendable distally beyond a distal end section of the cannulated outer shaft such that, when the cannulated outer shaft is engaging the proximal end of the anchor body, the distal end of the inner shaft is extendable through the anchor body to a distance beyond the distal end of the anchor body to engage a suture located within the suture receiving aperture, wherein the anchoring system is configured such that the suture can be tensioned at a location within the bore distal from the anchor body before the anchor body is implanted within

Abstract: Methods and compositions generating and using an interleukin-1 receptor antagonist (IL-1ra)-rich solution. Methods for generating and isolating interleukin-1 receptor antagonist include incubating a liquid volume of white blood cells and platelets with polyacrylamide beads to produce interleukin-1 receptor antagonist. The interleukin-1 receptor antagonist is isolated from the polyacrylamide beads to obtain the solution rich in interleukin-1 receptor antagonist. Methods for treating a site of inflammation in a patient include administering to the site of inflammation the solution rich in interleukin-1 receptor antagonist.

Abstract: A system and method for remote manufacturing of medical devices are provided. The system can be installed at a facility (e.g., at a hospital or other medical facility), and includes a remote manufacturing unit (RMU) that allows for customized, rapid fabrication of medical devices at the medical facility using suitable manufacturing techniques such as three-dimensional (3D) printing, additive manufacturing, subtractive manufacturing, etc. The RMU can communicate with a computer system which presents a healthcare professional with a digital catalog of medical products, and allows the healthcare professional to select and customize a desired device to be manufactured at the facility.

Abstract: An implant configured for fusing a first bone segment and a second bone segment during an operative procedure and constructed in accordance to one example of the present disclosure includes an implant body, a first bone interfacing portion and a second bone interfacing portion. The implant body can extend longitudinally between an insertion end and an opposite end. The first bone interfacing portion can be provided on the implant body and be configured to be implanted relative to the first bone segment. The second bone interfacing portion can be provided on the implant body and be configured to be implanted relative to the second bone segment. The first and second bone interfacing portions can be inserted dorsally into the first and second bone segments, respectively.

Abstract: Methods and compositions generating and using an interleukin-1 receptor antagonist (IL-1ra)-rich solution. Methods for generating and isolating interleukin-1 receptor antagonist include incubating a liquid volume of white blood cells and platelets with polyacrylamide beads to produce interleukin-1 receptor antagonist. The interleukin-1 receptor antagonist is isolated from the polyacrylamide beads to obtain the solution rich in interleukin-1 receptor antagonist. Methods for treating a site of inflammation in a patient include administering to the site of inflammation the solution rich in interleukin-1 receptor antagonist.

Abstract: A method and apparatus for securing a suture to bone can include grasping a first suture portion with a grasping member on a positioning tool. The first suture portion can be located into a first cannulation defined in the positioning tool. A cutting member can be advanced through a second cannulation defined on the positioning tool and out through a distal opening defined on the positioning tool. A first bone hole can be cut into the bone with the cutting member. A flexible member advancing tool can be advanced through the first cannulation. The first suture portion can be urged out of the distal opening and into the first bone hole.