Abstract: The present disclosure provides novel heteroaryl compounds of formula (IX). Such compounds are useful for the treatment of cancers.

Abstract: The disclosure features macrocyclic compounds, alone and in combination with other therapeutic agents, as well as pharmaceutical compositions and protein complexes thereof, capable of modulating biological processes including RAS and RAS-RAF inhibition, and their uses in the treatment of cancers.

Abstract: Some embodiments described in this disclosure are directed to electronic devices that present indications of changes to a shared document and/or to the users in a messaging conversation while displaying the messaging conversation. Some embodiments described in this disclosure are directed to electronic devices that present options to update the users with access to shared documents and/or messaging conversations. Some embodiments described in this disclosure are directed to electronic devices that participate in communication sessions associated with a shared document.

Abstract: A separator for a crop harvester configured to harvest sugarcane. The separator includes an extractor body that defines a chamber, the chamber extending through the extractor body and is in fluid communication with a cavity of a fan housing. The extractor body can generally define an inlet opening of the chamber, the inlet opening positioned to allow chopped billets and crop residue that are outputted from a chopper assembly to enter into the chamber. The inlet opening has a non-round, or non-circular configuration and/or cross sectional shape. Further, the inlet opening can have a width similar to a material flow width of the chopped billets and crop residue being outputted from the chopper assembly. Such a configuration can eliminate dead zones with respect to air flow that is to pull the chopped crop materials into the chamber and/or to separate crop residue from the chopped billets.

Abstract: Disclosed is an encoder which receives first to third input frames included first intra period and outputs a bitstream corresponding to the third input frame. The encoder includes a motion compensation unit that generates a first reference frame corresponding to the first input frame and a second reference frame corresponding to the second input frame, a union operation unit that generates an overlap frame by performing a union operation based on the first reference frame and the second reference frame, and an inter prediction unit that generates an occupancy code by performing an inter prediction operation on the overlap frame and the third input frame. In this case, the bitstream includes the occupancy code.

Abstract: The present disclosure provides novel heteroaryl compounds of formula (VII). Such compounds are useful for the treatment of cancers.

Abstract: A multi-band antenna system is provided. The antenna system can be placed under and embedded within a glass exterior surface of a vehicle. Such an antenna system can include a capacitively coupled metallic element on or adjacent to the glass exterior surface, which can serve as both a parasitic element to enhance gain and as a heating element to melt snow and/or ice accumulation over the glass area that covers the antenna. In certain applications, the antenna's structure itself can be used as a heater to improve performance in adverse weather conditions while the heating elements are positioned away from the thermally sensitive electronics. The antenna system with integrated heating can include a spiral antenna.

Abstract: A set of carpal tunnel syndrome relief devices is provided for treatment of a subject. The set includes several devices configured to be applied to a wrist which may have various shapes and sizes. Each device may be configured for an adhesive application to a skin area on a proximal side of a wrist over a median nerve of the subject. One device may be selected to match the profile of the skin of the subject and provide a distance from the peak of the middle portion to the underlying skin of about 3 to 6 mm—so as to achieve optimal pull of the skin above the median nerve and relief of carpal tunnel syndrome. An alternative, subject-specific design of the carpal tunnel syndrome relief device profile is also described.

Abstract: A novel pillow is provided to easily adjust its height by pulling a lever on the side of the pillow to activate the air control valve configured to personalize the head support needed for that individual. Pulling the lever to a fully open position creates a larger air passage to the inflatable bladder and activates an air pump for rapid inflation of the pillow so as to increase its height. With a user head laying over the pillow, pulling a lever slightly opens up a smaller opening suitable for gradual deflation of the pillow and reducing its height caused by the pressure generated by the head. Soft comfort portion on top of the pillow enclosed in a stretchable fabric reduces surface tension and creates a softer feeling for the user thereby improving comfort and consequently sleep quality. An altimeter may be incorporated with the bladder to easily monitor sleep patterns of the user.

Abstract: A set of carpal tunnel syndrome relief devices is provided for treatment of a subject. The set includes several devices configured to be applied to a wrist which may have various shapes and sizes. Each device may be configured for an adhesive application to a skin area on a proximal side of a wrist over a median nerve of the subject. One device may be selected to match the profile of the skin of the subject and provide a distance from the peak of the middle portion to the underlying skin of about 3 to 6 mm—so as to achieve optimal pull of the skin above the median nerve and relief of carpal tunnel syndrome. An alternative, subject-specific design of the carpal tunnel syndrome relief device profile is also described.

Abstract: A novel pillow is provided to easily adjust its height by pulling one or both levers of a unique double-lever air valve. Pulling a first lever opens up a smaller opening suitable for gradual deflation of the pillow and reducing its height under a pressure of a user head laying over the pillow. Pulling both levers together activates an electrically driven air pump to rapidly inflate the pillow through a larger opening so as to increase its height.

Abstract: A device (100, 200, 300) for identifying an arterial location includes a housing (110, 210, 310) with a tactile pressure sensor array (150, 250, 350) configured to detect pulsations of an artery once positioned over the presumed location of an artery. One of several LED lights (132, 232, 332) is energized to guide a clinician towards a preferred location of needle 10 insertion. The method of the invention comprises steps of positioning the device over the artery, reading pressure signals from individual pressure sensors, identifying peaks of pulsations and selecting the individual pressure sensor with the highest pulsation peaks as the closest to the artery located underneath. A corresponding LED light (132, 232, 332) is then activated to facilitate percutaneous access to the artery.

Abstract: Encoding data includes: encoding a residual of a first portion of an array of data to generate a first set of coefficients; decoding the first set of coefficients to generate a decoded representation of the first portion; computing an estimated covariance function for a residual of a second portion of the array of data based on a model that includes a gradient of a plurality of boundary data values located on a boundary of the decoded representation of the first portion; computing a set of transform basis functions from the estimated covariance function; and encoding the residual of the second portion using a first transform that uses the computed set of transform basis functions.

Abstract: A novel pillow is provided to easily adjust its height by pulling one or both levers of a unique double-lever air valve. Pulling a first lever opens up a smaller opening suitable for gradual deflation of the pillow and reducing its height under a pressure of a user head laying over the pillow. Pulling both levers together activates an electrically driven air pump to rapidly inflate the pillow through a larger opening so as to increase its height.

Abstract: A novel pillow is provided to easily adjust its height by pulling a lever on the side of the pillow to activate the air control valve configured to personalize the head support needed for that individual. Pulling the lever to a fully open position creates a larger air passage to the inflatable bladder and activates an air pump for rapid inflation of the pillow so as to increase its height. With a user head laying over the pillow, pulling a lever slightly opens up a smaller opening suitable for gradual deflation of the pillow and reducing its height caused by the pressure generated by the head. Soft comfort portion on top of the pillow enclosed in a stretchable fabric reduces surface tension and creates a softer feeling for the user thereby improving comfort and consequently sleep quality. An altimeter may be incorporated with the bladder to easily monitor sleep patterns of the user.

Abstract: A capacitive tactile sensor for measuring location and force of touch from an external object includes a drive electrode layer separated from a sense electrode layer by a dielectric substrate, which may be a two-sided FPCB. A first deformable conductive shield layer is further provided and is separated from either the drive electrode layer or the sense electrode layer by a first compressible dielectric layer. A control electronics are operatively connected to all of the drive electrode layer, sense electrode layer, and the first conductive shield layer. The control electronics may be configured to measure a change in capacitance upon the external object imparting local mechanical compression onto the first conductive shield layer and the first compressible dielectric layer. The tactile sensor improves reliability of interconnections between drive and sense electrodes and the control electronics.

Abstract: A force sensing touch screen input device is a solid assembly of multiple layers including a display with a touch-sensitive external surface, a first and second electrode layers separated by a compressible dielectric structure—forming a capacitive force-sensing array, and a rigid planar substrate. One or both electrode layers may be formed by metallizing a polymer surface of the rigid substrate or by creating a conductive electrode onto an internal surface of the display. To increase reliability, each layer is permanently adhered to or formed onto an adjacent layer over its entire surface, whereby preventing internal shifts therebetween. To increase response time, the cover glass flexibility, compressible dielectric structure and the gasket structure between the cover glass and the rigid planar substrates are selected to provide elastic compression and recovery during normal operating conditions.

Abstract: Encoding data includes: encoding a residual of a first portion of an array of data to generate a first set of coefficients; decoding the first set of coefficients to generate a decoded representation of the first portion; computing an estimated covariance function for a residual of a second portion of the array of data based on a model that includes a gradient of a plurality of boundary data values located on a boundary of the decoded representation of the first portion; computing a set of transform basis functions from the estimated covariance function; and encoding the residual of the second portion using a first transform that uses the computed set of transform basis functions.