Abstract: Compositions and devices comprising apomorphine or pharmaceutically acceptable salts are described. The compositions may comprise a solution of apomorphine, or a pharmaceutically acceptable salt thereof, and a propellant. The solution may be a non-aqueous solution or an aqueous solution comprising degassed water. Devices may be configured to deliver compositions in form of particles or droplets having a mass median aerodynamic diameter (MMAD) or volume median diameter (VMD) greater than 10 pm; and/or a fine particle fraction (FRF) less than 30%.

Abstract: In an apparatus for collecting aerosolised respirable particles of an inhalable medicinal formulation, aerosolised formulation is drawn pneumatically through a dose collection section comprising an inlet orifice (201) and an air-permeable filter (206), the filter being positioned opposed to said orifice, and extending across the pathway (4) for filtering the pneumatic flow so as to retain particulate material therein on the filter, and the orifice (201) being so dimensioned and configured that it has an unimpeded area that is no less than 75% of the area of the filter (201) on which the dose will be collected. In a method using the apparatus, particles (209, 210) collected on the filter may optionally be subjected to a dissolution test. A good correlation is obtainable between in vitro and in vivo doses with improved independence of loading.

Abstract: Provided herein are pharmaceutical formulations, nasal irrigation fluids, sachets, kits and the like comprising cephalosporin antibiotics, as well as methods of topical treatment of sinusitis and related conditions, methods of delivery of the formulations and fluids to the sinuses, methods of coating the sinuses, and methods of disruption and/or penetration of biofilms in the sinuses.

Abstract: In an apparatus for collecting aerosolised respirable particles of an inhalable medicinal formulation, aerosolised formulation is drawn pneumatically through a dose collection section comprising an inlet orifice (201) and an air-permeable filter (206), the filter being positioned opposed to said orifice, and extending across the pathway (4) for filtering the pneumatic flow so as to retain particulate material therein on the filter, and the orifice (201) being so dimensioned and configured that it has an unimpeded area that is no less than 75% of the area of the filter (201) on which the dose will be collected. In a method using the apparatus, particles (209, 210) collected on the filter may optionally be subjected to a dissolution test. A good correlation is obtainable between in vitro and in vivo doses with improved independence of loading.

Abstract: In an apparatus for collecting aerosolised respirable particles of an inhalable medicinal formulation, aerosolised formulation is drawn pneumatically through a dose collection section comprising an inlet orifice (201) and an air-permeable filter (206), the filter being positioned opposed to said orifice, and extending across the pathway (4) for filtering the pneumatic flow so as to retain particulate material therein on the filter, and the orifice (201) being so dimensioned and configured that it has an unimpeded area that is no less than 75% of the area of the filter (201) on which the dose will be collected. In a method using the apparatus, particles (209, 210) collected on the filter may optionally be subjected to a dissolution test. A good correlation is obtainable between in vitro and in vivo doses with improved independence of loading.

Abstract: Provided herein are pharmaceutical formulations, nasal irrigation fluids, sachets, kits and the like comprising cephalosporin antibiotics, as well as methods of topical treatment of sinusitis and related conditions, methods of delivery of the formulations and fluids to the sinuses, methods of coating the sinuses, and methods of disruption and/or penetration of biofilms in the sinuses.

Abstract: Provided herein are pharmaceutical formulations, nasal irrigation fluids, sachets, kits and the like comprising cephalosporin antibiotics, as well as methods of topical treatment of sinusitis and related conditions, methods of delivery of the formulations and fluids to the sinuses, methods of coating the sinuses, and methods of disruption and/or penetration of biofilms in the sinuses.

Abstract: In an apparatus for collecting aerosolised respirable particles of an inhalable medicinal formulation, aerosolised formulation is drawn pneumatically through a dose collection section comprising an inlet orifice (201) and an air-permeable filter (206), the filter being positioned opposed to said orifice, and extending across the pathway (4) for filtering the pneumatic flow so as to retain particulate material therein on the filter, and the orifice (201) being so dimensioned and configured that it has an unimpeded area that is no less than 75% of the area of the filter (201) on which the dose will be collected. In a method using the apparatus, particles (209, 210) collected on the filter may optionally be subjected to a dissolution test. A good correlation is obtainable between in vitro and in vivo doses with improved independence of loading.

Abstract: Provided herein are pharmaceutical formulations, nasal irrigation fluids, sachets, kits and the like comprising cephalosporin antibiotics, as well as methods of topical treatment of sinusitis and related conditions, methods of delivery of the formulations and fluids to the sinuses, methods of coating the sinuses, and methods of disruption and/or penetration of biofilms in the sinuses.

Abstract: The present invention relates to a simple, robust and effective process for preparing a dry powder inhalation formulation containing at least one drug, preferably a highly active drug, more preferably Tiotropium bromide or Tiotropium bromide monohydrate, and a lactose carrier. The process is characterized in that a three-layered composition containing a drug layer in between layers of the lactose carrier is mixed and the obtained preblend is mixed with additional lactose carrier. The process combines a simple manufacturing procedure with an excellent content uniformity obtained over a wide range of mixing parameters.