Abstract: Compositions and methods of capturing one or more nucleic acid molecules of a cell or subcellular compartment are described. In certain aspects, the compositions comprise a caged molecule comprising one or more photolinkers and an antisense oligonucleotide, which when uncaged hybridizes to a target nucleic acid molecule.

Abstract: The present invention provides a lens capsule incision device capable of applying differential power for lens capsule incision to a lens capsule incising part according to the contact states of electrodes of the lens capsule incising part with the lens capsule. The lens capsule incision device, which has a lens capsule incising part adapted to incise the lens capsule and having electrodes, includes: a measuring part for measuring an impedance in a state in which the electrodes of the lens capsule incising part come into contact with the lens capsule; a state determining part for determining a current contact state of the electrodes with the lens capsule, based on the impedance measured through the measuring part; and a power application part for applying differential power for lens capsule incision to the lens capsule incising part according to the current contact state determined by the state determining part.

Abstract: An apparatus for embedding a sentence feature vector according to an embodiment includes a sentence acquisitor configured to acquire a first sentence and a second sentence, each including one or more words; a vector extractor configured to extract a first feature vector corresponding to the first sentence and a second feature vector corresponding to the second sentence by independently inputting each of the first sentence and the second sentence into a feature extraction network; and a vector compressor configured to compress the first feature vector and the second feature vector into a first compressed vector and a second compressed vector, respectively, by independently inputting each of the first feature vector and the second feature vector into a convolutional neural network (CNN)-based vector compression network.

Abstract: A capsulorhexis device is inserted into an incision site of a cornea to make an incision in an anterior capsule surrounding a crystalline lens. The capsulorhexis device includes a loop having elasticity and conductivity; a moving member having one end fixed and coupled to the loop; an insertion guide configured so that, while the incision is being made in the crystalline lens capsule, a front end thereof is inserted into the incision site of the cornea; and a housing having one end coupled to a rear end of the insertion guide, wherein the loop is housed in the housing and, to make the incision in the crystalline lens capsule, slides in the housing together with the moving member to pass through the insertion guide and be deployed into an anterior chamber of the eye.

Abstract: A surgical apparatus is configured to support at least one bone cut for installation of a prosthetic component. The installed prosthetic component will have reduced alignment error. The surgical apparatus is configured to distract a first compartment to a first predetermined load value while allowing a moving support structure to pivot freely. A distraction lock mechanism is then engaged to prevent movement of a distraction mechanism that raises or lowers the moving support structure relative to a fixed support structure. The moving support structure has M-L tilt angle that is measured. A M-L tilt mechanism is engaged to forcibly equalize the first and second compartments. Engaging the M-L tilt mechanism prevents the moving support structure from freely pivoting. The at least one bone cut relates to the first and second compartments equalized and the M-L tilt angle.

Abstract: A surgical apparatus is configured to support at least one bone cut for installation of a prosthetic component. The installed prosthetic component will have reduced alignment error. The surgical apparatus is configured to distract a first compartment to a first predetermined load value while allowing a moving support structure to pivot freely. A distraction lock mechanism is then engaged to prevent movement of a distraction mechanism that raises or lowers the moving support structure relative to a fixed support structure. The moving support structure has M-L tilt angle that is measured. A M-L tilt mechanism is engaged to forcibly equalize the first and second compartments. Engaging the M-L tilt mechanism prevents the moving support structure from freely pivoting. The at least one bone cut relates to the first and second compartments equalized and the M-L tilt angle.

Abstract: A surgical apparatus for making an incision in a living tissue according to the present disclosure includes a hand piece including a loop-type electrode part and a generator configured to transmit electrical energy to the electrode part, wherein the generator applies electric-field pulse waveforms made of two consecutive pulse groups to the electrode part, the two consecutive pulse groups include a first pulse group and a second pulse group, each pulse group includes mini-pulses, a peak voltage of the first pulse group is less than a peak voltage of the second pulse group, and a duration of the first pulse group is longer than a duration of the second pulse group.

Abstract: Disclosed herein are methods for producing virus-infected cell lines or animal models, wherein an enveloped virus including a lipid bilayer is mixed with a bile acid or a bile acid derivative, which allows the lipid bilayer to be replaced with a lipid bilayer derived from a target animal. Also disclosed herein are the virus-infected cell lines or animal models so produced and methods of screening a therapeutic candidate for a viral disease using the same.

Abstract: The present invention relates to a method for detecting a virus, and more particularly, to a method for detecting a virus including a lipid bilayer envelope, wherein the method allows a surface antigen, which is a lipid bilayer envelope protein, to be effectively exposed from lipoproteins that mask all or part of the envelope protein, thereby revealing the surface antigen that is masked by the lipoproteins, so that a probe such as an antibody can be used to detect the virus with high sensitivity within a short time.

Abstract: A bone cut system comprising a distractor, one or more drill guides, one or more bone cutting jigs, a computer, and a display. The distractor includes electronic circuitry configured to control a measurement process and transmit measurement data. The distractor can include a magnetic distance sensor, a magnetic angle sensor, and load sensors configured to measure a distraction distance, medial-lateral angle, load magnitude applied to the distractor, and position of load in real-time. The distractor equalizes a medial and lateral compartment of a knee joint in flexion or extension at a predetermined loading. Guide holes are drilled to support cuttings with the medial and lateral compartments equalized. The distractor is configured to support one or more bone cuts using cutting jigs coupled to the guide holes that supports installation of a prosthetic component in alignment with a mechanical axis of a leg.

Abstract: Provided herein is a capsulorhexis device (100) inserted into an incision site of a cornea to make an incision in an anterior capsule surrounding a crystalline lens. The capsulorhexis device includes a loop (110) having elasticity and conductivity, a moving member (120) having one end fixed and coupled to the loop (110), a head part (130) including a housing configured to store the loop (110) therein and an insertion guide (131) coupled to one end portion of the housing to communicate therewith, and a body (140) that is coupled to the other end portion of the housing and has a sliding button (141) provided to slide the loop (110) and the moving member (120) through the head part (130).

Abstract: A hanger for preventing reverse flow includes: a body; a pair of supports extending from the body, being apart from each other, and forming a gripping portion housing the cloth inserted in a forward direction; a hanging pressure adjusting piece extending from at least one of the body and the pair of supports; a reverse flow preventing piece obliquely extending towards the body from one of the pair of supports and the hanging pressure adjusting piece and having an extending end that elastically faces the other one of the pair of supports and the hanging pressure adjusting piece; and a hanging pressure adjusting piece projection formed on at least one of the body and the pair of supports so that the hanging pressure adjusting piece is hung thereon to adjust elasticity of the reverse flow preventing piece.

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating a keloid disease or scars. The inventors of the present invention discovered that mortalin expression inhibition and the interaction between mortalin and p53 may be new targets for keloid treatment. In the present invention, apoptosis and an anti-fibrotic effect were verified by preparing a mortalin-specific shRNA (dE1-RGD/GFP/shMOT) and injecting same in a keloid spheroid. Thus, by reducing ECM expression and inducing apoptosis in a keloid spheroid, mortalin knockdown may be very usefully employed for keloid treatment.

Abstract: A surgical apparatus is configured to support at least one bone cut for installation of a prosthetic component. The installed prosthetic component will have reduced alignment error. The surgical apparatus is configured to distract a first compartment to a first predetermined load value while allowing a moving support structure to pivot freely. A distraction lock mechanism is then engaged to prevent movement of a distraction mechanism that raises or lowers the moving support structure relative to a fixed support structure. The moving support structure has M-L tilt angle that is measured. A M-L tilt mechanism is engaged to forcibly equalize the first and second compartments. Engaging the M-L tilt mechanism prevents the moving support structure from freely pivoting. The at least one bone cut relates to the first and second compartments equalized and the M-L tilt angle.

Abstract: A measurement system for installation of a prosthetic component. The measurement system comprises a housing, a slide block, a medial plate, a lateral plate, a fixed plate, and a threaded shaft. The fixed plate couples to the housing. The threaded shaft couples to the slide block. The threaded shaft is rotated to move the slide block within the housing. The slide block includes a free wheel gear. A medial plate and a lateral plate respectively couple to a medial post and a lateral post. The medial post and lateral post each have gear teeth that is configured to couple the free wheel gear. The housing retains, aligns and supports movement of the medial and lateral post parallel to the slide block. A medial brake and a lateral brake is configured to couple to the medial post and the lateral post to prevent movement under user control.

Abstract: The present invention provides a capsulorhexis apparatus for incising the anterior capsule covering the crystalline lens by being inserted into an incision site of the cornea. The capsulorhexis apparatus comprises: an anterior capsule incision part which has a closed curve-shape, is inserted in an incision site of an incised cornea so as to incise one portion of the anterior capsule positioned at the lower part of the cornea, and generates heat by applying a current in order to incise the anterior capsule; a body part in which the anterior capsule incision part slidingly moves so that the anterior capsule incision part is exposed to the outside when same is incising one portion of the anterior capsule, and is inserted inside the body part when same is not incising the anterior capsule; and a button part which is formed on one surface of the body part and slidingly moves the anterior capsule incision part inside the body part.

Abstract: A portable electronic device and a protection case thereof are provided. The portable electronic device includes a memory; a display; and a processor configured to acquire, from a flexible element included in a protection case of the portable electronic device, a characteristic value of the flexible element, the characteristic value changing according to bending of the flexible element through movement of the protection case, and determine a state of the protection case, based in the acquired characteristic value.

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating a keloid disease or scars. The inventors of the present invention discovered that mortalin expression inhibition and the interaction between mortalin and p53 may be new targets for keloid treatment. In the present invention, apoptosis and an anti-fibrotic effect were verified by preparing a mortalin-specific shRNA (dE1-RGD/GFP/shMOT) and injecting same in a keloid spheroid. Thus, by reducing ECM expression and inducing apoptosis in a keloid spheroid, mortalin knockdown may be very usefully employed for keloid treatment.

Abstract: A surgical apparatus is configured to support at least one bone cut for installation of a prosthetic component. The installed prosthetic component will have reduced alignment error. The surgical apparatus is configured to distract a first compartment to a first predetermined load value while allowing a moving support structure to pivot freely. A distraction lock mechanism is then engaged to prevent movement of a distraction mechanism that raises or lowers the moving support structure relative to a fixed support structure. The moving support structure has M-L tilt angle that is measured. A M-L tilt mechanism is engaged to forcibly equalize the first and second compartments. Engaging the M-L tilt mechanism prevents the moving support structure from freely pivoting. The at least one bone cut relates to the first and second compartments equalized and the M-L tilt angle.

Abstract: A measurement system for installation of a prosthetic component. The measurement system comprises a housing, a slide block, a medial plate, a lateral plate, a fixed plate, and a threaded shaft. The fixed plate couples to the housing. The threaded shaft couples to the slide block. The threaded shaft is rotated to move the slide block within the housing. The slide block includes a free wheel gear. A medial plate and a lateral plate respectively couple to a medial post and a lateral post. The medial post and lateral post each have gear teeth that is configured to couple the free wheel gear. The housing retains, aligns and supports movement of the medial and lateral post parallel to the slide block. A medial brake and a lateral brake is configured to couple to the medial post and the lateral post to prevent movement under user control.