Abstract: The present disclosure refers to a process of obtaining a biocrude from biomass, where said process comprises the solvothermal liquefaction of the biomass in the presence of a mixture of solvents, until obtaining a gaseous phase, a solid phase, an aqueous liquid phase and an organic liquid phase comprising the biocrude. Wherein the mixture of solvents comprises between 0.5% w/w to 99.5% w/w of water and at least one solvent; and wherein the solvent is selected from alcohols, ketones, aldehydes, or precursors thereof under the processing conditions. The process described herein allows the use of biomass for the production of renewable fuels, as well as obtaining a biocrude with a yield greater than or equal to 30%, with a calorific value between 20 and 35 MJ/Kg and with a sulfur percentage lower than 1% w/w.

Abstract: The present disclosure refers to a process of obtaining a biocrude from biomass, where said process comprises the solvothermal liquefaction of the biomass in the presence of a mixture of solvents, until obtaining a gaseous phase, a solid phase, an aqueous liquid phase and an organic liquid phase comprising the biocrude. Wherein the mixture of solvents comprises between 0.5% w/w to 99.5% w/w of water and at least one solvent; and wherein the solvent is selected from alcohols, ketones, aldehydes, or precursors thereof under the processing conditions. The process described herein allows the use of biomass for the production of renewable fuels, as well as obtaining a biocrude with a yield greater than or equal to 30%, with a calorific value between 20 and 35 MJ/Kg and with a sulfur percentage lower than 1% w/w.

Abstract: An intragastric anchor implant device with an elongate member having proximal and distal ends with atraumatic features disposed thereon is described herein. The atraumatic features inhibit damage to the tissues of the stomach and the gastrointestinal tract and help anchor the device. The elongate member may be substantially rigid to resist bending and engage a tissue of the stomach or gastrointestinal tract to prevent passage therethrough and may include one or more bends to conform to the shape of the tract. The anchor implant device may be coupled with a therapeutic device, such as an intestinal bypass sleeve with a sliding seal, such as an expandable structure, that secures the sleeve to direct a flow of food particles from the stomach therethrough, for use in treating various disorders, including obesity and diabetes. Methods of deploying the anchor implant devices are also disclosed.

Abstract: An intragastric implant comprises an anchor and a therapeutic device or a diagnostic device. The anchor is adapted to extend between the fundus and the pyloric valve of a stomach, to be retained without attachment to the stomach wall, and to anchor the device within the stomach with a relatively stable position and orientation. The therapeutic or diagnostic device is adapted to extend from the esophagus or stomach to the intestines or stomach. The therapeutic or diagnostic device, when extending into the esophagus, will be slidably received through the gastroesophageal junction and, when extending into the intestines, will be slidably received in the pyloric valve.

Abstract: An embodiment of the invention provides a prosthesis delivery system comprising a delivery catheter having an expandable member and a prosthesis carried over the expandable member. The prosthesis includes a radially expandable scaffold section and at least two anchors extending axially from an end thereof; and means for capturing at least the anchors to prevent the anchors from divaricating from the expandable member as the catheter is advanced through a patient's vasculature.

Abstract: An intragastric implant comprises an anchor and a therapeutic device or a diagnostic device. The anchor is adapted to extend between the fundus and the pyloric valve of a stomach, to be retained without attachment to the stomach wall, and to anchor the device within the stomach with a relatively stable position and orientation. The therapeutic or diagnostic device is adapted to extend from the esophagus or stomach to the intestines or stomach. The therapeutic or diagnostic device, when extending into the esophagus, will be slidably received through the gastroesophageal junction and, when extending into the intestines, will be slidably received in the pyloric valve.

Abstract: An intragastric anchor implant device is provided with a substantially rigid member having proximal and distal ends and atraumatic tips or features disposed near the proximal and distal ends. The atraumatic features prevent damage to the tissues of the stomach and the gastrointestinal track and may help to anchor the device in the stomach, while the substantially rigid member resists bending so as to engage a tissue of the stomach or the gastrointestinal tract to prevent passage through the stomach. The anchor implant device is coupled with a therapeutic device, typically a sleeve, such as an intestinal bypass sleeve. Ideally, the device includes a sliding seal to direct a flow of food particles from the stomach through the sleeve, so as to be useful in treating a disorder, including obesity and diabetes. Methods of deploying the anchor implant devices are also disclosed.

Abstract: The invention is a process for producing ethanol from sugarcane bagasse, the principal steps of which are mild sulphuric acid hydrolysis of the hemicellulose fraction of the sugarcane bagasse, followed by extraction of the hydrolysate and then fermentation thereof with the yeast Pichia stipitis. The process can be carried out with different solid : liquid ratios, and provides a step of acclimatizing the Pichia stipitis yeast, which results in a greater rate of ethanol production. The process takes place in a press reactor specially designed for this purpose, which allows more efficient extraction of the hydrolysate and, as a consequence, better process performance.

Abstract: An intragastric anchor implant device is provided with a substantially rigid member having proximal and distal ends and atraumatic tips or features disposed near the proximal and distal ends. The atraumatic features prevent damage to the tissues of the stomach and the gastrointestinal track and may help to anchor the device in the stomach, while the substantially rigid member resists bending so as to engage a tissue of the stomach or the gastrointestinal tract to prevent passage through the stomach. The anchor implant device is coupled with a therapeutic device, typically a sleeve, such as an intestinal bypass sleeve. Ideally, the device includes a sliding seal to direct a flow of food particles from the stomach through the sleeve, so as to be useful in treating a disorder, including obesity and diabetes. Methods of deploying the anchor implant devices are also disclosed.

Abstract: An embodiment of the invention provides a prosthesis delivery system comprising a delivery catheter having an expandable member and a prosthesis carried over the expandable member. The prosthesis includes a radially expandable scaffold section and at least two anchors extending axially from an end thereof; and means for capturing at least the anchors to prevent the anchors from divaricating from the expandable member as the catheter is advanced through a patient's vasculature.

Abstract: An intragastric anchor implant device is provided with a substantially rigid member having proximal and distal ends and atraumatic tips or features disposed near the proximal and distal ends. The atraumatic features prevent damage to the tissues of the stomach and the gastrointestinal track and may help to anchor the device in the stomach, while the substantially rigid member resists bending so as to engage a tissue of the stomach or the gastrointestinal tract to prevent passage through the stomach. The anchor implant device is coupled with a therapeutic device, typically a sleeve, such as an intestinal bypass sleeve. Ideally, the device includes a sliding seal to direct a flow of food particles from the stomach through the sleeve, so as to be useful in treating a disorder, including obesity and diabetes. Methods of deploying the anchor implant devices are also disclosed.

Abstract: An embodiment of the invention provides a prosthesis delivery system comprising a delivery catheter having an expandable member and a prosthesis carried over the expandable member. The prosthesis includes a radially expandable scaffold section and at least two anchors extending axially from an end thereof; and means for capturing at least the anchors to prevent the anchors from divaricating from the expandable member as the catheter is advanced through a patient's vasculature.

Abstract: An embodiment of the invention provides a prosthesis for placement at an Os opening from a main body lumen to a branch body lumen. The prosthesis comprises a radially expansible support and at least one frond extending axially from an end of the support. The support is configured to be deployed in at least a portion of a first body lumen, which can be a branch body lumen. At least one frond is extendable into across an ostium, e.g., from the first body lumen into a second body lumen, which may be a main body lumen.

Abstract: An embodiment of the invention provides a prosthesis delivery system comprising a delivery catheter having an expandable member and a prosthesis carried over the expandable member. The prosthesis includes a radially expandable scaffold section and at least two anchors extending axially from an end thereof; and means for capturing at least the anchors to prevent the anchors from divaricating from the expandable member as the catheter is advanced through a patient's vasculature.

Abstract: An embodiment of the invention provides a prosthesis for placement at an Os opening from a main body lumen to a branch body lumen. The prosthesis comprises a radially expansible support and a plurality of fronds extending axially from an end of the support. The support is configured to be deployed in at least a portion of the branch body lumen. At least one of the plurality of fronds is extendable into the main body lumen.

Abstract: An embodiment of the invention provides a prosthesis delivery system comprising a delivery catheter having an expandable member and a prosthesis carried over the expandable member. The prosthesis includes a radially expandable scaffold section and at least two anchors extending axially from an end thereof; and means for capturing at least the anchors to prevent the anchors from divaricating from the expandable member as the catheter is advanced through a patient's vasculature.

Abstract: An intragastric implant comprises an anchor and a therapeutic device or a diagnostic device. The anchor is adapted to extend between the fundus and the pyloric valve of a stomach, to be retained without attachment to the stomach wall, and to anchor the device within the stomach with a relatively stable position and orientation. The therapeutic or diagnostic device is adapted to extend from the esophagus or stomach to the intestines or stomach. The therapeutic or diagnostic device, when extending into the esophagus, will be slidably received through the gastroesophageal junction and, when extending into the intestines, will be slidably received in the pyloric valve.

Abstract: An anastomosis device is a one piece device for connecting a graft vessel to a target vessel without the use of conventional sutures. The anastomosis device includes an expandable tube configured to have a graft vessel secured to the tube. The device has an expandable linkage positioned at one end of the device and expansion of this linkage causes a first radially extending flange to fold outward. This first flange abuts an interior wall of a target vessel and a second flange is formed which abuts an exterior wall of the target vessel trapping the target vessel between the two flanges and secures the end of the graft vessel into an opening in the wall of the target vessel. The device greatly increases the speed with which anastomosis can be performed over known suturing methods and allows anastomosis to be performed in tight spaces.

Abstract: A prosthesis includes a radially expansible scaffold in at least two circumferential anchors extending from the scaffold. The prosthesis is placed across an os between a main body lumen and a branch lumen. The scaffold is expanded within the branch lumen and the circumferential anchors deformed outwardly to conform to the wall of the main body lumen. Optionally, a second prosthesis may be placed within the main body lumen after the first prosthesis has been deployed.

Abstract: An apparatus for performing anastomosis between a graft vessel and a target vessel may include a trocar that may create an opening in the target vessel. At least part of the trocar may be expandable to allow an anastomosis device to pass through the distal end thereof. The apparatus may include a holder configured to hold the anastomosis device, and place and deploy the anastomosis device in the opening created by the trocar.