Patents by Inventor Jale Muslehiddinoglu

Jale Muslehiddinoglu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for Preparing Imetelstat
    Publication number: 20230070069
    Abstract: The present invention relates to a process for preparing the telomerase inhibitor imetelstat using a 3 steps per cycle solid-phase support bound process comprising the steps of deprotection of the 3?-amino group of the support-bound oligonucleotide, coupling with a 5?-phosphoramidite, and sulfurization with an acyl disulfide, characterized by the absence of an additional capping step in each cycle that is used to prevent unreacted 3?-amino oligonucleotide groups from reacting during subsequent cycles. Imetelstat has formula below.
    Type: Application
    Filed: April 12, 2022
    Publication date: March 9, 2023
    Inventors: Jale MUSLEHIDDINOGLU, Dinesh GALA, Jennifer Elizabeth ALBANEZE-WALKER
  • Process for preparing imetelstat
    Patent number: 11332489
    Abstract: The present invention relates to a process for preparing the telomerase inhibitor imetelstat using a 3 steps per cycle phase support bound process comprising the steps of deprotection of the 3?-amino group of the support-bound oligonucleotide, coupling with a 5?-phosphoramidite, and sulfurization with an acyl disulfide, characterized by the absence of an additional capping step in each cycle that is used to prevent unreacted 3?-amino oligonucleotide groups from reacting during subsequent cycles. Imetelstat has formula below.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: May 17, 2022
    Assignee: Geron Corporation
    Inventors: Jale Muslehiddinoglu, Dinesh Gala, Jennifer Elizabeth Albaneze-Walker
  • Improved Process for Preparing Imetelstat
    Publication number: 20200369702
    Abstract: The present invention relates to a process for preparing the telomerase inhibitor imetelstat using a 3 steps per cycle phase support bound process comprising the steps of deprotection of the 3?-amino group of the support-bound oligonucleotide, coupling with a 5?-phosphoramidite, and sulfurization with an acyl disulfide, characterized by the absence of an additional capping step in each cycle that is used to prevent unreacted 3?-amino oligonucleotide groups from reacting during subsequent cycles. Imetelstat has formula below.
    Type: Application
    Filed: July 9, 2018
    Publication date: November 26, 2020
    Inventors: Jale MUSLEHIDDINOGLU, Dinesh GALA, Jennifer Elizabeth ALBANEZE-WALKER
  • Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use
    Patent number: 9434735
    Abstract: Provided herein is an amorphous form of 4-((4-(Cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-N-methylbenzamide, compositions thereof, and methods of their use for treating or preventing a cancer, in particular solid tumors and hematological cancers as described herein.
    Type: Grant
    Filed: July 13, 2015
    Date of Patent: September 6, 2016
    Assignee: Signal Pharmaceuticals, LLC
    Inventors: Ming J. Chen, Jale Muslehiddinoglu, Alexander Ruchelman, Terrence Joseph Connolly
  • AMORPHOUS FORM OF 4-((4-(CYCLOPENTYLOXY)-5-(2-METHYLBENZO[D]OXAZOL-6-YL)-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL)AMINO)-3-METHOXY-N-METHYLBENZAMIDE, COMPOSITIONS THEREOF AND METHODS OF THEIR USE
    Publication number: 20160009722
    Abstract: Provided herein is an amorphous form of 4-((4-(Cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-N-methylbenzamide, compositions thereof, and methods of their use for treating or preventing a cancer, in particular solid tumors and hematological cancers as described herein.
    Type: Application
    Filed: July 13, 2015
    Publication date: January 14, 2016
    Inventors: Ming J. CHEN, Jale MUSLEHIDDINOGLU, Alexander RUCHELMAN, Terrence Joseph Connolly
  • SOLID FORMS OF 2-(TERT-BUTYLAMINO)-4-((1R,3R,4R)-3-HYDROXY-4-METHYLCYCLOHEXYLAMINO)-PYRIMIDINE-5-CARBOXAMIDE, COMPOSITIONS THEREOF AND METHODS OF THEIR USE
    Publication number: 20150210650
    Abstract: Provided herein are formulations, processes, solid forms and methods of use relating to 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide.
    Type: Application
    Filed: January 29, 2015
    Publication date: July 30, 2015
    Inventors: Antonio Christian Ferretti, Hon-Wah Man, Jale Muslehiddinoglu, Jean Xu, Kelvin Hin-Yeong Yong, Marie Georges Beauchamps, Mohit Atul Kothare, Nanfei Zou, Nathan Andrew Boersen, Ying Li, Ying Ye
  • Process for the preparation of [(1R), 2S]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2, 1-F][1,2,4]triazin-6-yloxy]-1-methylethyl ester
    Patent number: 7671199
    Abstract: The invention relates to an improved process for preparing [(1R), 2S]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-methylethyl ester of the formula: Compound I has been shown to be useful for the treatment of certain types of cancer.
    Type: Grant
    Filed: April 20, 2007
    Date of Patent: March 2, 2010
    Assignee: Britsol-Myers Squibb Company
    Inventors: Gerard A. Crispino, Mourad Hamedi, Thomas L. LaPorte, John E. Thornton, Jaan A. Pesti, Zhongmin Xu, Paul C. Lobben, David K. Leahy, Jale Muslehiddinoglu, Chiajen Lai, Lori Ann Spangler, Robert P. Discordia, Francis S. Gibson
  • PROCESS FOR THE PREPARATION OF [(1R), 2S]-2-AMINOPROPIONIC ACID 2-[4-(4-FLUORO-2-METHYL-1H-INDOL-5-YLOXY)-5-METHYLPYRROLO[2,1-f][1,2,4]TRIAZIN-6-YLOXY]-1-METHYLETHYL ESTER
    Publication number: 20070249610
    Abstract: The invention relates to an improved process for preparing [(1R),2S]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-methylethyl ester of the formula: Compound I has been shown to be useful for the treatment of certain types of cancer.
    Type: Application
    Filed: April 20, 2007
    Publication date: October 25, 2007
    Inventors: Gerard Crispino, Mourad Hamedi, Thomas LaPorte, John Thornton, Jaan Pesti, Zhongmin Xu, Paul Lobben, David Leahy, Jale Muslehiddinoglu, Chiajen Lai, Lori Spangler, Robert Discordia