Abstract: System and method for selecting a transmission medium on which to transmit a first stream. At least one of the plurality of transmission media may be substantially dynamic in nature. Path characteristics of each of a plurality of transmission media may be determined. A first transmission medium may be selected from the plurality of transmission media for the first stream based on the determined path characteristics. A first plurality of packets of the first stream may be transmitted on the first transmission medium.

Abstract: An asymmetric mixed-mode transceiver may determine to communicate with a destination powerline communication device. The asymmetric mixed-mode transceiver may determine whether an operational mode associated with the destination powerline communication device is a multiple-output multiple-input (MIMO) mode or a single-output single-input (SISO) mode. The asymmetric mixed-mode transceiver may dynamically change its operational mode to either the MIMO mode or the SISO mode to match the operational mode of the destination powerline communication device. The asymmetric mixed-mode transceiver may receive a communication from a source powerline communication device. The asymmetric mixed-mode transceiver may determine whether an operational mode associated with the source powerline communication device is the MIMO mode or the SISO mode. The asymmetric mixed-mode transceiver may dynamically change its operational mode to match the operational mode of the source powerline communication device.

Abstract: A hybrid device can implement functionality to automatically configure itself to form a home network with other network devices. If it is determined that the hybrid device is the central access point of a hybrid network, operating parameters are determined for the central access point. The central access point can then operate in conjunction with other non-CAP hybrid devices of the hybrid device to determine how to configure the non-CAP hybrid device. The configuration of the non-CAP hybrid device can be determined based, at least in part, on a communication link performance measurement between the CAP and the non-CAP hybrid device. Furthermore, the hybrid network can also be monitored to ensure that the hybrid devices do not repeatedly or randomly switch between different configurations.

Abstract: It is an object of the present invention to provide antimicrobial metallodrugs comprising an antimicrobial peptide (“AMP”) and/or an antibiotic covalently bound to a metal binding moiety. These metallodrugs combine a metal binding domain which typically catalyzes oxido-reductase chemistry or acts as a Lewis-Acid catalyst, with a member of a diverse class of antimicrobial agents currently validated in preclinical and clinical settings for the treatment of a broad spectrum of pathogenic organisms.

Abstract: It is an object of the present invention to provide improved pharmacological properties to molecules which bind to a target with low affinity (hereinafter referred to as a “ligand moiety”) through linkage of such molecules to a metal binding moiety, thereby generating a combination molecule commonly referred to as a “metallodrug” or “metallotherapeutic.” The metal binding domain of metallodrugs typically catalyzes oxido-reductase chemistry or acts as a Lewis-Acid catalyst, resulting in modification of proteins and nucleic acids that are in close proximity due to binding of the ligand moiety to its target.

Abstract: It is an object of the present invention to provide improved pharmacological properties to molecules which bind to a target with low affinity (hereinafter referred to as a “ligand moiety”) through linkage of such molecules to a metal binding moiety, thereby generating a combination molecule commonly referred to as a “metallodrug” or “metallotherapeutic.” The metal binding domain of metallodrugs typically catalyzes oxido-reductase chemistry or acts as a Lewis-Acid catalyst, resulting in modification of proteins and nucleic acids that are in close proximity due to binding of the ligand moiety to its target.

Abstract: An asymmetric mixed-mode transceiver may determine to communicate with a destination powerline communication device. The asymmetric mixed-mode transceiver may determine whether an operational mode associated with the destination powerline communication device is a multiple-output multiple-input (MIMO) mode or a single-output single-input (SISO) mode. The asymmetric mixed-mode transceiver may dynamically change its operational mode to either the MIMO mode or the SISO mode to match the operational mode of the destination powerline communication device. The asymmetric mixed-mode transceiver may receive a communication from a source powerline communication device. The asymmetric mixed-mode transceiver may determine whether an operational mode associated with the source powerline communication device is the MIMO mode or the SISO mode. The asymmetric mixed-mode transceiver may dynamically change its operational mode to match the operational mode of the source powerline communication device.

Abstract: System and method for selecting a transmission medium on which to transmit a first stream. At least one of the plurality of transmission media may be substantially dynamic in nature. Path characteristics of each of a plurality of transmission media may be determined. A first transmission medium may be selected from the plurality of transmission media for the first stream based on the determined path characteristics. A first plurality of packets of the first stream may be transmitted on the first transmission medium.

Abstract: Ligands having a metal binding domain and a targeting domain are provided. The ligands can be used to target, inhibit, and catalytically degrade or inactivate a desired target. Methods of treating a disease or condition using the ligands are also provided.

Abstract: It is an object of the present invention to provide improved pharmacological properties to molecules which bind to a target with low affinity (hereinafter referred to as a “ligand moiety”) through linkage of such molecules to a metal binding moiety, thereby generating a combination molecule commonly referred to as a “metallodrug” or “metallotherapeutic.” The metal binding domain of metallodrugs typically catalyzes oxido-reductase chemistry or acts as a Lewis-Acid catalyst, resulting in modification of proteins and nucleic acids that are in close proximity due to binding of the ligand moiety to its target.

Abstract: A continuous system for automatically manufacturing an axle is provided. The system includes a plurality of sub-systems and an automated transport system. The plurality of sub-systems includes a furnace configured to heat a billet to a predetermined forging temperature, a forging system configured to forge an axle from a heated billet, and a machining system configured to form a machined axle from said axle. The automated transport system is configured to automatically transport a product to and from each of the plurality of sub-systems. The product includes the billet, the axle, and the machined axle.

Abstract: A method for manufacturing an axle is provided. The method includes heating a billet at a heating station to a predetermined temperature, forging the heated billet at a forging station to form an axle, and machining the axle at a machining station to form a machined axle. A product is automatically transported to and from each station using a product transport system, wherein the product includes the billet, the axle and the machined axle.

Abstract: The invention relates to the use of bacterial cytolysin proteins, such as pneumolysin, as adjuvants for stimulating or enhancing immune responses against co-administered target antigens. Desirably, the target antigen is provided as a fusion protein with the cytolysin. The inventors have found that cytolysins may be particularly effective for stimulation of mucosal immune responses against the target antigen.

Abstract: A method for manufacturing an axle is provided. The method includes heating a billet at a heating station to a predetermined temperature, forging the heated billet at a forging station to form an axle, and machining the axle at a machining station to form a machined axle. A product is automatically transported to and from each station using a product transport system, wherein the product includes the billet, the axle and the machined axle.

Abstract: A vehicle seat for coupling to the floor of a vehicle comprising a seat back, a seat cushion, a first bracket, and a second bracket. The seat back is pivotable between at least a first position and a design position. The seat cushion is configured to be coupled to the vehicle floor. The first bracket is configured to be coupled to the vehicle floor and includes one of a keyed passage and a keyed pin configured to be received within the keyed passage. The second bracket is coupled to the seat back and includes the other one of the keyed passage and the keyed pin configured to be received within the keyed passage. The keyed passage is configured to receive the keyed pin only when the seat back is in a position the seat back will be prevented from assuming after the vehicle seat has been installed in the vehicle.

Abstract: A diffuser is disclosed which transmits or reflects incident light into a specific range of angles. In a preferred embodiment, this light is uniformly scattered throughout a cone of angles. The diffuser consists of two parts. The first part diffracts or reflects light into a specific offset angle. The second part, in the preferred embodiment, uniformly scatters the light through a range of angles, which is centered on the offset angle. The diffusers have utility in applications such as screens for wrist watches, computers, calculators, and cell phones.

Abstract: A vehicle seat for coupling to the floor of a vehicle comprising a seat back, a seat cushion, a first bracket, and a second bracket. The seat back is pivotable between at least a first position and a design position. The seat cushion is configured to be coupled to the vehicle floor. The first bracket is configured to be coupled to the vehicle floor and includes one of a keyed passage and a keyed pin configured to be received within the keyed passage. The second bracket is coupled to the seat back and includes the other one of the keyed passage and the keyed pin configured to be received within the keyed passage. The keyed passage is configured to receive the keyed pin only when the seat back is in a position the seat back will be prevented from assuming after the vehicle seat has been installed in the vehicle.

Abstract: Ligands having a metal binding domain and a targeting domain are provided. The ligands can be used to target, inhibit, and catalytically degrade or inactivate a desired target. Methods of treating a disease or condition using the ligands are also provided.

Abstract: A method for creating and transferring digitally created images on a film to a target surface via heat and/or pressure transfer using a modified large-format digital printer. The method generally comprises the steps of modifying a large-format digital printer to convert it from heat fused toner printing to cold toner printing, preparing a transfer film, creating a digital image, applying a release layer onto the transfer film, printing the image onto the release layer on the transfer film in a reverse mirror-image manner, applying an adhesive overtop said image, and pressure transferring the image onto the target substrate and peeling away the transfer film to selectively leave the image on the target substrate. The present method results in a cleaner, clearer more eye-catching graphic deposited in a more robust, wear-tolerant manner on a wider variety of substrates including rough and porous materials such as leather.