Abstract: A braille cell and associated braille pin support and pin actuation assemblies are disclosed. The braille cell can include a frame, braille pins movable up and down between raised and lowered positions, and a pin actuation assembly to individually move the pins. The braille cell can include support arms, each of which having a base end connected to the frame and a pin end connected to and following a motion of a respective pin between its raised and lowered positions. The pin actuation assembly can include pin actuation units, each having a motor with a rotatable motor shaft and multiple cams mounted on the shaft, each for selectively actuating a respective pin. Each pin actuation unit can also include an angular position sensing system for monitoring, for example magnetically, a passage of the shaft through a reference angular position, and deriving information about a current angular position of the shaft.

Abstract: An enzyme responsive shape memory polymer formed from a glassy, cross-linked shape memory polymer that incorporates ester bonds that are responsive to the present of an enzyme. PCL-based polyurethanes (featuring simple alternation of PCL diol and lysine-based diisocyanate) are degradable by Amano lipase PS. A non-degradable thermoplastic elastomer may be dual electrospun with a polycaprolactone based TPU with the fixing phase compressed so that the composite is ready for enzymatically triggered contraction. Alternatively, the elastomer may be a PCL copolymer-based polyurethane amorphous elastomer that is both degradable and elastomeric and put into compression so that upon enzymatic degradation of the elastomeric phase the scaffold expands.

Abstract: A three component system for repairing critically sized bone defects having a first shape memory polymer (SMP) component formed as a scaffold that fills the defects, a second SMP component formed as a restricting sleeve that stabilizes and supports osseointegration and osteoconduction, and a third SMP component formed as a two-dimensional cell culture substrate for engineering periosteal grafts.

Abstract: Some umbrellas include a support assembly, canopy assembly, and a toroidal air bladder. The support assembly includes a pump and a handle. The canopy assembly includes a plurality of support ribs attached to the handle, and a sheet attached to each of the support ribs. The toroidal air bladder is coupled to the air pump, and the air bladder disposed about the handle and engages the support ribs.

Abstract: The invention relates to triazole compounds of formula I and I? or pharmaceutically acceptable salts thereof, useful as modulators of demyelinating diseases: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention, methods of using the compositions and kits thereof in the treatment of various demyelinating and neurodegenerative diseases, including multiple sclerosis.

Abstract: Media objects, such as images or soundtracks, may be ranked according to a new class of metrics known as “interestingness.” These rankings may be based at least in part on the quantity of user-entered metadata concerning the media object, the number of users who have assigned metadata to the media object, access patterns related to the media object, and/or a lapse of time related to the media object.

Abstract: A digital download kiosk network is described. The network comprises: an authorization database including a digital rights management facility; a first digital download kiosk coupled to the authorization database to receive digital rights management data; and a second digital download kiosk coupled to the authorization database to receive digital rights management data, and coupled to the first digital download kiosk in a peer-to-peer manner to share multi-media content therebetween.

Abstract: Some umbrellas include a support assembly, canopy assembly, and a toroidal air bladder. The support assembly includes a pump and a handle. The canopy assembly includes a plurality of support ribs attached to the handle, and a sheet attached to each of the support ribs. The toroidal air bladder is coupled to the air pump, and the air bladder disposed about the handle and engages the support ribs.

Abstract: This invention provides amine-linked C3-glutarimide Degronimers and Degrons for therapeutic applications as described further herein, and methods of use and compositions thereof as well as methods for their preparation.

Abstract: This invention provides heterocyclic compounds that bind to E3 Ubiquitin Ligase (typically through cereblon) (“Degrons”), which can be used as is or linked to a Targeting Ligand for a selected Target Protein for therapeutic purposes and methods of use and compositions thereof as well as methods for their preparation.

Abstract: This invention provides compounds that have spirocyclic E3 Ubiquitin Ligase targeting moieties (Degrons), which can be used as is or linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.

Abstract: This invention provides Degronimers that have carbon-linked E3 Ubiquitin Ligase targeting moieties (Degrons), which can be linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.

Abstract: Media objects, such as images or soundtracks, may be ranked according to a new class of metrics known as “interestingness.” These rankings may be based at least in part on the quantity of user-entered metadata concerning the media object, the number of users who have assigned metadata to the media object, access patterns related to the media object, and/or a lapse of time related to the media object.

Abstract: An aft heat shield for a fuel nozzle tip includes: an annular shield wall; an annular shield flange extending radially outward from an aft end of the shield wall; an annular baffle flange surrounding the conical section, and disposed such that an axial gap is defined between the shield flange and the baffle flange, the baffle flange including a radially outer rim extending axially forward therefrom; and a plurality of impingement cooling holes passing through the baffle flange and oriented to as to direct air flow towards the shield wall.

Abstract: Metadata may be associated with media objects by providing media objects for display, and accepting input concerning the media objects, where the input may include at least two different types of metadata. For example, metadata may be in the form of tags, comments, annotations or favorites. The media objects may be searched according to metadata, and ranked in a variety of ways.

Abstract: The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3K?. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract: The invention relates to triazole compounds of formula I and I? or pharmaceutically acceptable salts thereof, useful as modulators of demyelinating diseases: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention, methods of using the compositions and kits thereof in the treatment of various demyelinating and neurodegenerative diseases, including multiple sclerosis.

Abstract: Some umbrellas include a support assembly, canopy assembly, and a toroidal air bladder. The support assembly includes a pump and a handle. The canopy assembly includes a plurality of support ribs attached to the handle, and a sheet attached to each of the support ribs. The toroidal air bladder is coupled to the air pump, and the air bladder disposed about the handle and engages the support ribs.

Abstract: An aft heat shield for a fuel nozzle tip includes: an annular shield wall; an annular shield flange extending radially outward from an aft end of the shield wall; an annular baffle flange surrounding the conical section, and disposed such that an axial gap is defined between the shield flange and the baffle flange, the baffle flange including a radially outer rim extending axially forward therefrom; and a plurality of impingement cooling holes passing through the baffle flange and oriented to as to direct air flow towards the shield wall.

Abstract: Some umbrellas include a support assembly, canopy assembly, and a toroidal air bladder. The support assembly includes a pump and a handle. The canopy assembly includes a plurality of support ribs attached to the handle, and a sheet attached to each of the support ribs. The toroidal air bladder is coupled to the air pump, and the air bladder disposed about the handle and engages the support ribs.