Abstract: An externally worn cardiac monitoring and/or treatment system with battery detachment detection is provided. The system includes detachment circuitry and audible and/or vibrational alarm circuitry operably coupled to the detachment circuitry. The detachment circuitry is configured to detect whether the rechargeable battery is detached from the battery-powered externally worn cardiac device by monitoring a connection established between the rechargeable battery and the at least one processor and output a battery status signal indicating whether the rechargeable battery is detached from the battery-powered externally worn cardiac device. The audible and/or vibrational alarm circuitry is configured to receive the battery status signal and output an audible alert in a predetermined frequency range and/or a tactile alert if the rechargeable battery is detached.

Abstract: Dedicating hardware devices to virtual machines includes dedicating, by a hypervisor executing on a computer system, a set of hardware devices of the computer system to a first virtual machine of the hypervisor, the first virtual machine executing a guest operating system, and the set of hardware devices for use by the guest operating system in execution of the guest operating system, and dedicating network device hardware of the computer system to a second virtual machine of the hypervisor, the second virtual machine being a different virtual machine than the first virtual machine, wherein network communication between the guest operating system and a network to which the computer system is connected via the network device hardware occurs via the second virtual machine.

Abstract: The present disclosure provides compositions and methods for producing and using modified auxotrophic host cells for improved gene therapy involving administration of an auxotrophic factor.

Abstract: A content hosting system allows content providers to create channels of video content and make them available to users in a marketplace. Users can search or browse for channels of interest, and selectively subscribe to channels. Users can also pay for the right to view premium videos in each channel. The system ranks channels according to the value provided. Generally, users will seek out and subscribe to the highest ranked channels that provide the greatest value. The ranking function allows different providers to compete for the subscriptions of users. Providers can observe their channel's reception in the market by analyzing rankings and usage statistics to adjust channels to maximize channel performance. The system operator can also create bundled channels containing videos from multiple providers, and the resulting subscription revenue can be distributed to the various providers of the videos in the channel.

Abstract: A rotor module for an axial flux electric machine includes a back iron segment configured for attachment to a rotor base and a plurality of permanent magnets attached to the back iron segment. The back iron segment has a length less than a circumference of the rotor base. Each permanent magnet attached to the back iron segment has an opposite magnetic pole orientation from each adjacent permanent magnet attached to the back iron segment. A plurality of rotor modules is coupled to the rotor base to form a rotor for the axial flux electric machine.

Abstract: System and methods for providing a patient with arrhythmia treatment are described. For example, a system includes an arrhythmia monitoring and treatment assembly configured to be worn on the torso of the patient. The assembly has a housing discreetly extending from a skin surface of the patient. The assembly is configured to provide therapy on detecting one or more arrhythmia conditions of the patient. A first at least one user response button is disposed on the assembly at a first location on the torso concealed under clothing, and a second at least one user response button is configured to be worn on a second location of the patient's body, a location other than the torso that is accessible to the patient. The system suspends an impending therapy upon receiving a user input from either one of the first or second at least one user response buttons.

Abstract: A collapsible valve bridge actuation system that is configured to alter the lift of poppet valves in a reciprocating piston machine cylinder. The system has a rocker arm configured to be actuated by a cam lobe, and a collapsible valve bridge device that is functionally attached to the rocker arm. The device has a deactivation assembly that contains lock pins within a housing and springs. Also, the device is configured to remain rigid, partially collapse, or fully collapse. The extent of collapse is a function of the strength of the springs.

Abstract: A patient-worn arrhythmia monitoring and treatment device weight between 250 grams and 2,500 grams includes at least one contoured pad configured to be adhesively coupled to a patient's torso, a plurality of therapy electrodes, at least one of which is integrated with the at least one contoured pad, and a plurality of ECG sensing electrodes, at least one of which is integrated with the at least one contoured pad. At least one housing configured to form a watertight seal with the at least one contoured pad extends no more than 5 cm from the contoured pad. A processor disposed within the housing is coupled to a therapy delivery circuit and configured to detect one or more treatable arrhythmias based on at least one ECG signal and cause a therapy delivery circuit to deliver at least one defibrillation pulse on detecting the one or more treatable arrhythmias.

Abstract: A rotor for an electric machine includes a circular rotor base having a first surface, a second surface, and a circumferential outer edge extending from the first surface to the second surface, a plurality of magnets disposed proximate the circumferential outer edge of the circular rotor base, and a plurality of flux guides. Each magnet has a first surface and a second surface. The first surface of each magnet is attached to the first surface of the circular rotor base, and the second surface of each magnet defines a first shape. Each flux guide is attached to the second surface of a different magnet and has a first surface attached to the second surface of a first respective magnet and a second surface opposite the first surface. The second surface of each flux guide defines a second shape different than the first shape of the magnets.

Abstract: A stator for an axial flux machine includes a back iron, a plurality of stator teeth extending from the back iron, and a plurality of tooth tips attached to the stator teeth. The back iron and the stator teeth include a first material. Each stator tooth has a first end proximate the back iron and a second end. Each tooth tip is attached to the second end of a different stator tooth. The tooth tips include a second material different than the first material.

Abstract: An electric machine comprising a permanent magnet rotor assembly is provided. The electric machine comprises a permanent magnet rotor assembly comprising a plurality of permanent magnets coupled to a rotor disk and a plurality of magnet shims coupled to the plurality of permanent magnets opposite the rotor disk. Each magnet shim of the plurality of magnet shims has a substantially complementary shape as a respective permanent magnet of the plurality of permanent magnets. The electric machine further comprises a stator core comprising a plurality of stator teeth that define a plurality of slots therebetween. At least one of the plurality of magnet shims is configured to direct magnetic flux from at least one of the plurality of permanent magnets to at least one stator tooth of the plurality of stator teeth.

Abstract: A wearable cardiac monitoring and treatment device includes a garment, a plurality of ECG electrodes and a plurality of therapy electrodes supported by the garment. A fastener is configured to secure the garment about a torso of the patient for a prescribed duration. A disengagement sensor to provides an indication of disengagement of the fastener prior to expiration of the prescribed duration in which the garment is no longer secured about the torso of the patient. The device includes a therapy delivery circuit coupled to the plurality of therapy electrodes and configured to deliver one or more therapeutic pulses. A controller coupled to therapy delivery circuit is configured to analyze an ECG signal monitored by the plurality of ECG electrodes and, upon detecting one or more treatable arrhythmias, cause the therapy delivery circuit to deliver the one or more therapeutic pulses to the patient.

Abstract: The present invention provides regulatable cell lines with an engineered genome encoding an auxotrophic response system or element, and methods of use thereof. Growth and protein production of the cell lines is controlled by exposure of the cell line to an auxotrophic factor to activate the auxotrophic response system or element. Examples of auxotrophic factors include a nutrient, an enzyme, a moiety that alters pH, a moiety that alters temperature, a non-organic molecule, a non-essential amino acid, an altered concentration of a moiety, and a cellular niche environment. These regulatable cell lines may be used in regenerative medicine and enzyme replacement therapy.

Abstract: Dedicating hardware devices to virtual machines includes dedicating, by a hypervisor executing on a computer system, a set of hardware devices of the computer system to a first virtual machine of the hypervisor, the first virtual machine executing a guest operating system, and the set of hardware devices for use by the guest operating system in execution of the guest operating system, and dedicating network device hardware of the computer system to a second virtual machine of the hypervisor, the second virtual machine being a different virtual machine than the first virtual machine, wherein network communication between the guest operating system and a network to which the computer system is connected via the network device hardware occurs via the second virtual machine.

Abstract: A method of producing a non-planar conforming circuit on a non-planar surface includes creating a first set of conforming layers. The first set of conforming layers is created by applying an oxide dielectric layer to the surface, applying a conductive material layer to the oxide dielectric layer, applying a resist layer to the conductive material layer, patterning the resist layer according to a desired circuit layout, etching the surface to remove exposed conductive material, and stripping the resist layer. The process may be repeated to form multiple layers of conforming circuits with electrical connections between layers formed by blind microvias. The resulting set of conforming layers can be sealed.

Abstract: A method of producing a non-planar conforming circuit on a non-planar surface includes creating a first set of conforming layers. The first set of conforming layers is created by applying an oxide dielectric layer to the surface, applying a conductive material layer to the oxide dielectric layer, applying a resist layer to the conductive material layer, patterning the resist layer according to a desired circuit layout, etching the surface to remove exposed conductive material, and stripping the resist layer. The process may be repeated to form multiple layers of conforming circuits with electrical connections between layers formed by blind microvias. The resulting set of conforming layers can be sealed.

Abstract: A light system (FIG. 2) is disclosed. The light system includes a plurality of series connected light emitting diodes (240-246). Each of a plurality of switching devices (230-236) has a control terminal and each has a current path coupled in parallel with a respective LED. A plurality of fault detector circuits (220-226) are each coupled in parallel with a respective light emitting diode. Each fault detector circuit has a first comparator (FIG. 7, 704) arranged to compare a voltage across the respective light emitting diode to a respective first reference voltage (708). When a fault is detected, a control signal is applied to the control terminal to turn on a respective switching device of the plurality of switching devices.

Abstract: An electronic book system provides interfaces particularly suited to students' use of textbooks. User-controlled content is associated with portions of an electronic book. A study guide corresponding to at least some of the portions with associated user-controlled content is generated. The user can navigate between portions of the study guide and the corresponding portions of the electronic book.

Abstract: Systems and methods are disclosed for analyzing and predicting spending behaviors of consumers. A financial service system configures a financial service account for a user associated with a merchant. The financial service system, after receiving notification of purchase transactions made by the user with the account, may collect information relating to the transactions. The financial service system may determine other merchants that “co-occur” with the first merchant—in other words, where else are the first merchant's customers shopping and who are their true competitors? The financial service system may then compile this data and provide it to the merchant, who may modify their business practices based on the information.