Patents by Inventor James A. Radosevich
James A. Radosevich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220409709Abstract: Antigenic compositions comprising one or more labyrinthin-derived peptides are described herein. In some embodiment, each peptide of the antigenic composition comprises a T-cell epitope and/or a B-cell epitope. In other aspects, the present disclosure provides, e.g., vaccine compositions comprising tin antigenic composition disclosed herein, including kits, medicines, and compositions (such as pharmaceutical compositions and unit dosages) thereof. Also provided are methods of using the compositions disclosed herein, such as methods of treatment thereof and methods of producing antibodies, and antibody compositions thereof, against the one or more labyrinthin-derived peptides or a portion thereof.Type: ApplicationFiled: December 13, 2019Publication date: December 29, 2022Inventors: James A. RADOSEVICH, Michael BABICH
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Publication number: 20220089719Abstract: Constructs comprising an antibody moiety that specifically binds to Labyrinthin or a portion thereof and an effector domain are provided. Also provided are methods of making and using these constructs and compositions thereof.Type: ApplicationFiled: January 7, 2020Publication date: March 24, 2022Applicant: LabyRx Immunologic Therapeutics (USA) LimitedInventors: Michael BABICH, James A. RADOSEVICH
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Publication number: 20170175084Abstract: Tumor stem cells can be obtained by culturing a tumor cell population, and exposing the cultured tumor cell population to free radicals. In certain embodiments, the free radical agent can be a nitric oxide (NO) donor. In one embodiment, the free radical agent can be Diethylenetriamine NONOate (DETA NONOate) or agents that constitutively increase cellular nitric oxide, such as phosphodiesterase inhibitors or L-arginine, or agents that increase NO synthase in the population. The methods can further include inducing stem cells present in the population to expand and/or inducing dedifferentiation of tumor cells into tumor stem cells. Additionally, the present invention provides methods of selecting stem cells from a tumor cell population.Type: ApplicationFiled: March 7, 2017Publication date: June 22, 2017Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventor: James A. RADOSEVICH
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Publication number: 20130252236Abstract: Tumor stem cells can be obtained by culturing a tumor cell population, and exposing the cultured tumor cell population to free radicals. In certain embodiments, the free radical agent can be a nitric oxide (NO) donor. In one embodiment, the free radical agent can be Diethylenetriamine NONOate (DETA NONOate) or agents that constitutively increase cellular nitric oxide, such as phosphodiesterase inhibitors or L-arginine, or agents that increase NO synthase in the population. The methods can further include inducing stem cells present in the population to expand and/or inducing dedifferentiation of tumor cells into tumor stem cells. Additionally, the present invention provides methods of selecting stem cells from a tumor cell population.Type: ApplicationFiled: September 28, 2012Publication date: September 26, 2013Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventor: James A. Radosevich
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Patent number: 8163883Abstract: A cDNA molecule that encodes a protein designated Labyrinthin (Lab) isolated and its nucleotide sequence is determined. The protein, or peptides derived from the protein, are markers useful to define novel classes of cancers. Diagnostic assays for these cancers use antibodies to Lab or nucleotide probes that hybridize with the lab gene or a fragment therefrom. Vaccines useful either to prevent recurrence of cancers in subjects who test positive for Lab (or lab), or to prevent initial occurrence of cancer, use proteins or peptides derived from Lab. Expression of Lab via immunogenic assays is used to monitor effects of cancer treatments. Antisense molecules against lab are used in treatments. Sense molecules of lab are used to restore lost lab function in diseased normal cells, for example, gland cells.Type: GrantFiled: October 23, 2009Date of Patent: April 24, 2012Assignee: Mission Therapeutics, Inc.Inventor: James Radosevich
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Publication number: 20110293753Abstract: Compositional formulations are provided that comprise at least one tocotrienol or a derivative thereof, in combination with compounds derived from plant extracts. The compositions can be provided in a functionally acceptable carrier, or separately in a combined regimen. In some examples, the compositions can be effective for reducing, preventing or treating medical conditions including, for example, benign tissue growths, pre-cancerous lesions, cancer, inflammations, viral infections, bacterial infections, fungal infections, parasitic infections, impaired bodily function, or cell and tissue damage due to trauma, cell and/or tissue injury from stroke events, cell and/or tissue damage from ischemic events. The mechanism of action for cancer prevention and therapy includes telomerase and/or angiogenesis inhibition.Type: ApplicationFiled: May 28, 2010Publication date: December 1, 2011Inventors: Louis Bellafiore, James A. Radosevich, Ed Glicken
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Publication number: 20110293525Abstract: Tumor stem cells can be obtained by culturing a tumor cell population, and exposing the cultured tumor cell population to free radicals. In certain embodiments, the free radical agent can be a nitric oxide (NO) donor. In one embodiment, the free radical agent can be Diethylenetriamine NONOate (DETA NONOate) or agents that constitutively increase cellular nitric oxide, such as phosphodiesterase inhibitors or L-arginine, or agents that increase NO synthase in the population. The methods can further include inducing stem cells present in the population to expand and/or inducing dedifferentiation of tumor cells into tumor stem cells. Additionally, the present invention provides methods of selecting stem cells from a tumor cell population.Type: ApplicationFiled: May 31, 2011Publication date: December 1, 2011Applicant: BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventor: James A. Radosevich
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Publication number: 20110110963Abstract: A cDNA molecule that encodes a protein designated Labyrinthin (Lab) isolated and its nucleotide sequence is determined. The protein, or peptides derived from the protein, are markers useful to define novel classes of cancers. Diagnostic assays for these cancers use antibodies to Lab or nucleotide probes that hybridize with the lab gene or a fragment therefrom. Vaccines useful either to prevent recurrence of cancers in subjects who test positive for Lab (or lab), or to prevent initial occurrence of cancer, use proteins or peptides derived from Lab. Expression of Lab via immunogenic assays is used to monitor effects of cancer treatments. Antisense molecules against lab are used in treatments. Sense molecules of lab are used to restore lost lab function in diseased normal cells, for example, gland cells.Type: ApplicationFiled: March 16, 2010Publication date: May 12, 2011Inventor: James Radosevich
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Publication number: 20100233711Abstract: A cDNA molecule that encodes a protein designated Labyrinthin (Lab) isolated and its nucleotide sequence is determined. The protein, or peptides derived from the protein, are markers useful to define novel classes of cancers. Diagnostic assays for these cancers use antibodies to Lab or nucleotide probes that hybridize with the lab gene or a fragment therefrom. Vaccines useful either to prevent recurrence of cancers in subjects who test positive for Lab (or lab), or to prevent initial occurrence of cancer, use proteins or peptides derived from Lab. Expression of Lab via immunogenic assays is used to monitor effects of cancer treatments. Antisense molecules against lab are used in treatments. Sense molecules of lab are used to restore lost lab function in diseased normal cells, for example, gland cells.Type: ApplicationFiled: March 16, 2010Publication date: September 16, 2010Inventor: James Radosevich
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Publication number: 20100112582Abstract: A cDNA molecule that encodes a protein designated Labyrinthin (Lab) isolated and its nucleotide sequence is determined. The protein, or peptides derived from the protein, are markers useful to define novel classes of cancers. Diagnostic assays for these cancers use antibodies to Lab or nucleotide probes that hybridize with the lab gene or a fragment therefrom. Vaccines useful either to prevent recurrence of cancers in subjects who test positive for Lab (or lab), or to prevent initial occurrence of cancer, use proteins or peptides derived from Lab. Expression of Lab via immunogenic assays is used to monitor effects of cancer treatments. Antisense molecules against lab are used in treatments. Sense molecules of lab are used to restore lost lab function in diseased normal cells, for example, gland cells.Type: ApplicationFiled: October 23, 2009Publication date: May 6, 2010Inventor: James Radosevich
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Patent number: 7635759Abstract: A cDNA molecule that encodes a protein designated Labyrinthin (Lab) is isolated and its nucleotide sequence is determined. The protein, or peptides derived from the protein, are markers useful to define novel classes of cancers. Diagnostic assays for these cancers use antibodies to Lab or nucleotide probes that hybridize with the lab gene or a fragment therefrom. Vaccines useful either to prevent recurrence of cancers in subjects who test positive for Lab (or lab) or to prevent initial occurrence of cancer, use proteins or peptides derived from Lab. Expression of Lab via immunogenic assays is used to monitor effects of cancer treatments. Antisense molecules against lab are used in treatments. Sense molecules of lab are used to restore lost lab function in diseased normal cells, for example, gland cells.Type: GrantFiled: February 11, 2008Date of Patent: December 22, 2009Assignee: Immvarx, Inc.Inventor: James A. Radosevich
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Publication number: 20080249284Abstract: A cDNA molecule that encodes a protein designated Labyrinthin (Lab) is isolated and its nucleotide sequence is determined. The protein, or peptides derived from the protein, are markers useful to define novel classes of cancers. Diagnostic assays for these cancers use antibodies to Lab or nucleotide probes that hybridize with the lab gene or a fragment therefrom. Vaccines useful either to prevent recurrence of cancers in subjects who test positive for Lab (or lab) or to prevent initial occurrence of cancer, use proteins or peptides derived from Lab. Expression of Lab via immunogenic assays is used to monitor effects of cancer treatments. Antisense molecules against lab are used in treatments. Sense molecules of lab are used to restore lost lab function in diseased normal cells, for example, gland cells.Type: ApplicationFiled: February 11, 2008Publication date: October 9, 2008Applicant: IMMVARX, INC.Inventor: James Radosevich
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Patent number: 7329743Abstract: A cDNA molecule that encodes a protein designated Labyrinthin (Lab) is isolated and its nucleotide sequence is determined. The protein, or peptides derived from the protein, are markers useful to define novel classes of cancers. Diagnostic assays for these cancers use antibodies to Lab or nucleotide probes that hybridize with the lab gene or a fragment therefrom. Vaccines useful either to prevent recurrence of cancers in subjects who test positive for Lab (or lab), or to prevent initial occurrence of cancer, use proteins or peptides derived from Lab. Expression of Lab via immunogenic assays is used to monitor effects of cancer treatments. Antisense molecules against lab are used in treatments. Sense molecules of lab are used to restore lost lab function in diseased normal cells, for example, gland cells.Type: GrantFiled: April 23, 2004Date of Patent: February 12, 2008Assignee: ImmvaRx, Inc.Inventor: James Radosevich
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Publication number: 20050208508Abstract: A cDNA molecule that encodes a protein designated Labyrinthin (Lab) is isolated and its nucleotide sequence is determined. The protein, or peptides derived from the protein, are markers useful to define novel classes of cancers. Diagnostic assays for these cancers use antibodies to Lab or nucleotide probes that hybridize with the lab gene or a fragment therefrom. Vaccines useful either to prevent recurrence of cancers in subjects who test positive for Lab (or lab), or to prevent initial occurrence of cancer, use proteins or peptides derived for Lab. Expression of Lab via immunogenic assays is used to monitor effects of cancer treatments. Antisense molecules against lab are used in treatments. Sense molecules of lab are used to restore lost lab function in diseased normal cells, for example, gland cells.Type: ApplicationFiled: April 23, 2004Publication date: September 22, 2005Inventor: James Radosevich
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Patent number: 6727080Abstract: A cDNA molecule that encodes a protein designated Labyrinthin (Lab) is isolated and its nucleotide sequence is determined. The protein, or peptides derived from the protein, are markers useful to define novel classes of cancers. Diagnostic assays for these cancers use antibodies to Lab or nucleotide probes that hybridize with the lab gene or a fragment therefrom. Vaccines useful either to prevent recurrence of cancers in subjects who test positive for Lab (or lab), or to prevent initial occurrence of cancer, use proteins or peptides derived for Lab. Expression of Lab via immunogenic assays is used to monitor effects of cancer treatments. Antisense molecules against lab are used in treatments. Sense molecules of lab are used to restore lost lab function in diseased normal cells, for example, gland cells.Type: GrantFiled: September 12, 2000Date of Patent: April 27, 2004Assignee: ImmvaRx, Inc.Inventor: James Radosevich
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Publication number: 20030021798Abstract: The invention provides a method of enhancing an immune response to an immunogen in an animal. The method comprises administering to the animal an effective amount of the immunogen and an effective amount of a modified C-reactive protein (mCRP) or a mutant-mCRP. The invention also provides a vaccine and a method of producing this vaccine. The vaccine comprises an immunogen and an mCRP or a mutant-mCRP in a pharmaceutically-acceptable vehicle. The invention further provides a kit for immunizing an animal to an immunogen comprising (1) a container holding the immunogen and a container holding an mCRP or a mutant-mCRP or (2) a container holding the immunogen and an mCRP or a mutant-mCRP.Type: ApplicationFiled: September 24, 2002Publication date: January 30, 2003Applicant: Immtech International Inc.Inventors: Lawrence A. Potempa, James A. Radosevich
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Patent number: 6455046Abstract: The invention provides a method of enhancing an immune response to an immunogen in an animal. The method comprises administering to the animal an effective amount of the immunogen and an effective amount of a modified C-reactive protein (mCRP) or a mutant-mCRP. The invention also provides a vaccine and a method of producing this vaccine. The vaccine comprises an immunogen and an mCRP or a mutant-mCRP in a pharmaceutically-acceptable vehicle. The invention further provides a kit for immunizing an animal to an immunogen comprising (1) a container holding the immunogen and a container holding an mCRP or a mutant-mCRP or (2) a container holding the immunogen and an mCRP or a mutant-mCRP. The invention also provides a method of elicing an immune response to a hapten in an animal. The method comprises administering to the animal an effective amount of the hapten in association with an an effective amount of an mCRP or a mutant-mCRP. The invention further provides a vaccine and a method of producing this vaccine.Type: GrantFiled: May 9, 2000Date of Patent: September 24, 2002Assignee: Immtech International, Inc.Inventors: Lawrence A. Potempa, James A. Radosevich
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Publication number: 20020061843Abstract: The invention provides a method of delivering a material into a cell. The method comprises associating the material with a modified C-reactive protein (mCRP) or a mutant-mCRP. Then, the material associated with the mCRP or the mutant-mCRP is contacted with the cell so that the material is delivered into the cell.Type: ApplicationFiled: October 3, 2001Publication date: May 23, 2002Inventors: Lawrence A. Potempa, James A. Radosevich, Edward E. Diehl
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Publication number: 20020037535Abstract: The invention provides a method of slowing cell growth and promoting the maturation of cells other than cancer cells and megakaryocyte progenitor cells. The method comprises contacting the cells with a modified C-reactive protein (mCRP) or a mutant-mCRP. The method may be performed in vitro or in vivo.Type: ApplicationFiled: September 19, 2001Publication date: March 28, 2002Applicant: Immtech International Inc.Inventors: Lawrence A. Potempa, James A. Radosevich
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Patent number: 6331403Abstract: The invention provides a method of slowing cell growth and promoting the maturation of cells other than cancer cells and megakaryocyte progenitor cells. The method comprises contacting the cells with a modified C-reactive protein (mCRP) or a mutant-mCRP. The method may be performed in vitro or in vivo.Type: GrantFiled: August 18, 1999Date of Patent: December 18, 2001Inventors: Lawrence A. Potempa, James A. Radosevich