Patents by Inventor James Abraham Aikins

James Abraham Aikins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lactam compound
    Publication number: 20040248878
    Abstract: The present invention provides crystalline (N)—((S)-2-hydroxy-3-methyl-butyryl)-1-(L-alaninyl)-(S)-1-amino-3-methyl-4,5,6,7-tetrahydro-2H-3-benzazepin-2-one dihydrate, compositions thereof, and methods for using the same, processes for making the same, and processes for making intermediates thereof.
    Type: Application
    Filed: April 28, 2003
    Publication date: December 9, 2004
    Inventors: Thomas Mitchell Koenig, James Edmund Audia, David Mitchell, Stacey Leigh McDaniel, Lynne Ann Buccilli, Gary Lowell Engel, James Abraham Aikins
  • Sulfonamide derivatives
    Patent number: 6803484
    Abstract: The present invention relates to a compound of formula (Ia) or a pharmaceutically acceptable salt thereof which is useful for the treatment of conditions associated with glutamate hypofunction, such as psychiatric and neurological disorders.
    Type: Grant
    Filed: December 24, 2003
    Date of Patent: October 12, 2004
    Assignee: Eli Lilly and Company
    Inventors: James Abraham Aikins, Andrew Hendley Fray, William David Miller
  • Sulfonamide derivatives
    Publication number: 20040143020
    Abstract: The present invention relates to a compound of formula (Ia) or a pharmaceutically acceptable salt thereof which is useful for the treatment of conditions associated with glutamate hypofunction, such as psychiatric and neurological disorders.
    Type: Application
    Filed: December 24, 2003
    Publication date: July 22, 2004
    Inventors: James Abraham Aikins, Andrew Hendley Fray, William David Miller
  • Sulfonamide derivatives
    Publication number: 20030233015
    Abstract: The present invention relates to a compound of formula (Ia) or a pharmaceutically acceptable salt thereof which is useful for the treatment of conditions associated with glutamate hypofunction, such as psychiatric and neurological disorders.
    Type: Application
    Filed: October 17, 2002
    Publication date: December 18, 2003
    Inventors: James Abraham Aikins, Andrew Hendley Fray, William David Miller, Paul Leslie Ornstein, Hamideh Zarrinmayeh, Dennis Michael Zimmerman
  • Cyclopentyl sulfonamide derivatives
    Patent number: 6639107
    Abstract: The present invention provides certain cyclopentyl sulfonamide derivatives of formula (I): useful for potentiating glutamate receptor function in a mammal. It also relates to novel cyclopentyl sulfonamide derivatives, to processes for their preparation and to pharmaceutical compositions containing them.
    Type: Grant
    Filed: May 14, 2002
    Date of Patent: October 28, 2003
    Assignee: Eli Lilly and Company
    Inventors: James Abraham Aikins, Edward C R Smith, Timothy Alan Shepherd, Dennis Michael Zimmerman
  • Stereoselective process for producing intermediates of cryptophycins
    Patent number: 6376230
    Abstract: This invention provides processes for preparing intermediates useful for the preparation of cryptophycin compounds.
    Type: Grant
    Filed: October 8, 1999
    Date of Patent: April 23, 2002
    Assignee: Eli Lilly and Company
    Inventors: James Abraham Aikins, Barbara Shreve Briggs, Tony Yantao Zhang, Milton Joseph Zmijewski, Jr.
  • Optical resolution of aminoisobobutyric acid
    Patent number: 6372936
    Abstract: A process for resolving amino protected racemic 3-amino-2-methylpropionic acid which comprises the steps of: (1) reacting said amino protected acid with a protected amino group with an enantiomer of a chiral amine to form diastereomeric salts; (2) recrystallizing the diastereomeric salts from ethyl acetate to separate the diastereomeric salts into crystal fractions; and (3) releasing the resolved acid from the diastereomeric salt by treating the diastereomeric salt with a basic solution is disclosed. A process for the preparation of the cryptophycin molecules is also disclosed.
    Type: Grant
    Filed: May 8, 2000
    Date of Patent: April 16, 2002
    Assignee: Eli Lilly and Company
    Inventors: James Abraham Aikins, Tony Yantao Zhang