Abstract: Provided herein are compositions and methods for treating Pitt Hopkins Syndrome (PTHS) by restoring PTHS patient's gut microbiota. These methods can be used with PTHS patient with or without ongoing gastrointestinal symptoms. The methods comprise administering a therapeutic composition comprising a fecal microbe or a fecal microbe preparation to the subject.

Abstract: The present disclosure relates to compositions and methods for treating autism spectrum disorder (ASD) by restoring an ASD patient's gut microbiota. These methods can be used with ASD patient with or without ongoing gastrointestinal symptoms. Provided here is a method for modulating the abundance of one or more gut microorganisms in a subject in need thereof, said method comprising administering to said subject a therapeutically effective amount of a pharmaceutical composition comprising a fecal microbe preparation to achieve at least a 2-fold change of the abundance of said one or more fecal microorganisms, wherein said one or more gut microorganisms are selected from the group consisting of Bifidobacterium, Prevotella, Desulfovibrio, Copprococcus, Clostridium, and Bacteroides.

Abstract: A modular RF apparatus includes an RF portal and an RF expansion module configured to be coupled with the RF portal. The modular RF apparatus is configured to expand the number of outputs of the RF portal by adding the RF expansion module in a manner that minimizes an increase in the spatial footprint of the modular RF apparatus while allowing easy access to all ports of the modular RF apparatus. The RF portal and the RF expansion module are configured to interlock to create an integrated functional block. The modular RF apparatus are configured to permit upgrading of the RF portal by adding the RF expansion module without disrupting existing connections to the RF portal.

Abstract: The present disclosure relates to therapies for the treatment of a disorders characterized by a disorder-associated antigen (DAA); vaccination methods are disclosed. In particular, the disclosure describes anti-CD25 ADC molecular adjuvants for use in inducing or enhancing a subject's immune response against a DAA, allowing for treatment of the disorder characterized by the DAA. Also disclosed are dosage regiments for the treatment of solid tumours with an AThe present disclosure relates to the treatment of pathological conditions, such as cancer, with anti-CD25 ADCs.

Abstract: The present disclosure relates to compositions and methods for treating autism spectrum disorder (ASD) by restoring an ASD patient's gut microbiota. These methods can be used with ASD patient with or without ongoing gastrointestinal symptoms. Provided here is a method for ASD treatment in a subject in need thereof comprising or consisting essentially of administering a therapeutic composition comprising a fecal microbe or a fecal microbiota preparation to the subject. Also provided here is a method comprises administering an antibiotic to a human subject; subjecting the human subject to a bowel cleanse; and administering purified fecal microbiota to the human subject. Further provided are evaluation and quantitative characterization of patient symptom improvements upon treatment described here.

Abstract: A modular passive RF apparatus includes a passive RF portal and a passive RF expansion module configured to be removably coupled with the passive RF portal. A male connector is configured to extend from a top surface of the passive RF portal, and a female connector is configured to extend from the first end wall of the passive RF expansion portal. The female connector is configured to slidingly engage the male connector in a direction parallel to the top surface of the passive RF portal in order to mechanically couple the passive RF expansion module with the passive RF portal, and the male connector is configured to prevent the female connector from being removed from the male connector in a direction perpendicular to the top surface of the passive RF portal.

Abstract: The present disclosure relates to compositions and methods for treating autism spectrum disorder (ASD) by restoring an ASD patient's gut microbiota. These methods can be used with ASD patient with or without ongoing gastrointestinal symptoms. Provided here is a method for ASD treatment in a subject in need thereof comprising or consisting essentially of administering a therapeutic composition comprising a fecal microbe or a fecal microbiota preparation to the subject. Also provided here is a method comprises administering an antibiotic to a human subject; subjecting the human subject to a bowel cleanse; and administering purified fecal microbiota to the human subject. Further provided are evaluation and quantitative characterization of patient symptom improvements upon treatment described here.

Abstract: A vertically articulating trailer hitch assembly for use with a vehicle, and particularly for use with an autonomous vehicle. The trailer hitch assembly is pivotally attached to the vehicle frame. The hitch assembly is allowed to swing away from the vehicle frame from a lowered position in which the trailer ball is uncoupled from the hitch coupler of the trailer to a raised position in which the trailer ball is coupled to the hitch coupler. The hitch assembly typically includes a receiver that has a long axis. The vehicle frame has a long axis. When the hitch assembly is in its lowered position, the long axis of the receiver is out of alignment with the long axis of the frame. When the hitch assembly is in its raised position, the long axis of the receiver is aligned with the long axis of the frame.

Abstract: A method for processing orders on an electronic trading platform is provided. The method includes receiving, via a graphical user interface, an order relating to a request to transact in a first debt instrument from a party; extracting information relating to the first debt instrument from the order; determining, using at least one curating model and the extracted information, a counterparty relating to a potential participant to the order in a counterparty database; and transmitting, via a communication network, the order to the counterparty. The method further includes receiving, via the communication network, a response relating to the order from the counterparty, the response including a transaction parameter; and displaying, via a graphical user interface, the response together with the corresponding counterparty.

Abstract: This invention relates to photoswitchable inhibitors of histone deacetylases and methods of using the same.

Abstract: A floor assembly for a trailer includes a pair of longitudinally extending main beams, each having a first height dimension along a first longitudinal portion of the main beam and a second height dimension along a second portion of the main beam. The first height dimension being greater than the second height dimension. Cross members extend in a transverse direction between and connect the main beams. A plurality of floor members extend transversely between the main beams. The floor members including at least some reinforced floor members. The reinforced floor members have upper and lower walls and opposing side walls that define a rectangular cross-section and include a series of truss walls extending angularly between the upper and lower walls. The reinforced floor members are positioned on the upper surfaces of the main beams at least in part at the second height dimension.

Abstract: Vehicle suspension systems are described herein. An example apparatus includes a cam pivotably coupled to a rear axle. The example apparatus also includes a first tie rod having a first end pivotably coupled to the cam and a second end pivotably coupled to a steering knuckle. The example apparatus also includes a second tie rod having a first end pivotably coupled to the cam outboard relative to the first end of the first tie rod and a second end coupled to a steering actuator.

Abstract: A gas delivery system for a substrate processing system includes a first manifold and a second manifold. A gas delivery sub-system selectively delivers gases from gas sources. The gas delivery sub-system delivers a first gas mixture to the first manifold and a second gas mixture. A gas splitter includes an inlet in fluid communication with an outlet of the second manifold, a first outlet in fluid communication with an outlet of the first manifold, and a second outlet. The gas splitter splits the second gas mixture into a first portion at a first flow rate that is output to the first outlet and a second portion at a second flow rate that is output to the second outlet. First and second zones of the substrate processing system are in fluid communication with the first and second outlets of the gas splitter, respectively.

Abstract: A vibrometer may measure acoustic responses in portions of a structure along a scan path to acoustic excitation of the structure. A ranging device may measure distances to the portions of the structure along the scan path. A three-dimensional point cloud may be generated based on the acoustic responses in the portions of the structure and the distances to the portions of the structure. The three-dimensional point cloud may include points representing geometry of the portions of the structure. The points may be associated with the acoustic responses in corresponding portions of the structure. One or more properties of the structure may be determined based on an analysis of the three-dimensional point cloud.

Abstract: A telecommunications box includes a first housing portion, a second housing portion pivotally coupled with the first housing portion, an adapter panel removably coupled with the first housing portion, and an inner cover pivotally coupled with the first housing portion and removably coupled with the adapter panel. The adapter panel is configured to be uncoupled from the first housing so as to be pivotal with the inner cover relative to the first housing portion to a raised configuration that provides a technician with improved access to the adapter panel, and the adapter panel is configured to be uncoupled from the inner cover while remaining coupled with the first housing portion in a stowed configuration.

Abstract: Disclosed are puzzle devices for production of one or more puzzles. The puzzle devices can include a body and at least one input device. The body can include a plurality of panels, each panel configured to display one or more visual indicators. The at least one input device can include a plurality of panels, each panel configured to display a visual indicator. The at least one input device can move relative to the body to align one or more panels of the input device with one or more panels of the body. The body can further include a plurality of visual output devices configured to generate visual indicators on the plurality of panels of the body.

Abstract: A clamp assembly includes a clamp member and a clip. The clamp member includes a body and an aperture. The body includes an end portion, a first arm, and a second arm. The first arm and second arm each extend from the end portion. The first arm and second arm are laterally spaced apart from one another to form an opening positioned therebetween. The opening extends along an axis. The aperture extends through the first arm and the second arm in a direction orthogonal to the axis of the opening. The aperture is positioned proximate ends of the first arm and the second arm on an opposite side of the opening relative to the end portion. The clip includes a clip body extending partially about the opening axis and securing the clamp member against axial movement relative to the plunger.

Abstract: One or more embodiments disclosed herein relate generally to flotation devices, and more specifically to modular flotation devices with a mechanism to removably attach to other modular devices. In one embodiments, an apparatus includes a first flotation module and a first connector coupled to the first flotation module. The first connector has a first end portion, a second end portion and a sidewall extended from the first end portion to the second end portion. The sidewall defines a plurality of circumferentially defined stepped portions configured to matingly engage a second connector of a second flotation module to couple the first flotation module to the second flotation module. The first connector is selectively operative as one of a female connector or a male connector with respect to the second connector.