Abstract: The present invention relates to antibodies that specifically bind to one or more of IL-4, IL-13, IL-33, TSLP, and p40. The present invention further relates to antibodies that bind to one of IL-4, IL-13, IL-33, or TSLP. The invention further relates to multispecific antibodies that specifically bind to IL-4 and IL-13, and at least one other target. The present invention relates to multispecific antibodies that bind IL-4, IL-13, and one of IL-33, TSLP, or p40. The present invention also pertains to related molecules, e.g. nucleic acids which encode such antibodies or multispecific antibodies, compositions, and related methods, e.g., methods for producing and purifying such antibodies and multispecific antibodies, and their use in diagnostics and therapeutics.

Abstract: A hybrid component (30) having a cast single crystal superalloy portion (32) and an attached powder metallurgy material portion (34). The component may be a blade (30) of a gas turbine engine having a single crystal airfoil section and a powder metallurgy material root section. The powder metallurgy material may extend to form a core (36) within the airfoil section and may include cooling passages 38. The single crystal portion has a relatively simple geometry so that casting yields are optimized. The powder metallurgical portion includes the lower stressed and more complicated geometry sections of the component. A method of forming such a component includes casting the single crystal superalloy portion, then using that portion to form part of the mold for forming the powder metallurgy material portion.