Patents by Inventor James B. Eckenhoff, deceased
James B. Eckenhoff, deceased has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 6156331Abstract: The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved.Type: GrantFiled: May 12, 1999Date of Patent: December 5, 2000Assignee: ALZA CorporationInventors: John R. Peery, Keith E. Dionne, James B. Eckenhoff, deceased, Felix A. Landrau, Scott D. Lautenbach, Judy A Magruder, Jeremy C. Wright
-
Patent number: 6068850Abstract: This invention relates to stable liquid aqueous formulations of peptide compounds at high concentrations. These stable formulations comprise at least about 10% peptide in water. They may be stored at elevated temperatures for long periods of time and are especially useful in implantable delivery devices for long term delivery of drug.Type: GrantFiled: February 11, 1999Date of Patent: May 30, 2000Assignee: Alza CorporationInventors: Cynthia L. Stevenson, Sally A. Tao, Steven J. Prestrelski, James B. Eckenhoff, deceased, Jeremy C. Wright, John J. Leonard, Jr.
-
Patent number: 5981489Abstract: This invention relates to stable non-aqueous protic formulations of peptide compounds. These stable formulations comprise peptide in non-aqueous protic solvent. They may be stored at elevated temperatures for long periods of time and are especially useful in implantable delivery devices for long term delivery of drug.Type: GrantFiled: June 13, 1997Date of Patent: November 9, 1999Assignee: Alza CorporationInventors: Cynthia L. Stevenson, Sally A. Tao, Steven J. Prestrelski, James B. Eckenhoff, deceased, Jeremy C. Wright, John J. Leonard, Jr.
-
Patent number: 5972370Abstract: The present invention provides improved compositions for improving the chemical and physical stability of peptides and proteins. The invention provides a liquid beneficial agent formulation containing a liquid suspension comprising at least 5% by weight beneficial agent and having a viscosity and beneficial agent size which minimizes settling of the agent in suspension over the extended delivery period.Type: GrantFiled: January 28, 1999Date of Patent: October 26, 1999Assignee: Alza CorporationInventors: James B. Eckenhoff, deceased, Leslie A. Holladay, John Joseph Leonard, Jr., Iris K. M. Leung, Sally A. Tao, Judy A. Magruder, John P. Carr, Jeremy C. Wright
-
Patent number: 5941844Abstract: A method encompasses the substantially continuous electrotransport delivery of luteinizing hormone releasing hormone (LHRH), prologues, analogues, salts or mixtures thereof, preferably at a substantially constant rate, to a female mammal for the purpose of modifying its reproductive cycle. An electrotransport device substantially is suited for the continuous delivery of LHRH prologues, analogues, salts or mixtures thereof over an extended period of time to a mammal. The present technology may be successfully applied to the controlled breeding of mammals, such as thoroughbred race horses.Type: GrantFiled: November 17, 1997Date of Patent: August 24, 1999Assignee: ALZA CorporationInventor: James B. Eckenhoff, deceased
-
Patent number: 5922353Abstract: A delivery system is disclosed for delivering a fluid-sensitive active agent such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery system comprises a first wall section, a second wall section and a locking coupling therebetween. The coupled wall sections define a compartment, enclosing an active agent and an expandable driving member. Various embodiments of the locking coupling are disclosed.Type: GrantFiled: October 8, 1997Date of Patent: July 13, 1999Assignee: ALZA CorporationInventors: Judy A. Magruder, James B. Eckenhoff, deceased, Richard Cortese, Jeremy C. Wright, John R. Peery, Edward V. Bourneuf, James B. Pike, Urano A. Robinson, John M. Sharockman, Jonathan P. Smith
-
Patent number: 5916582Abstract: This invention relates to stable liquid aqueous formulations of peptide compounds at high concentrations. These stable formulations comprise at least about 10% peptide in water. They may be stored at elevated temperatures for long periods of time and are especially useful in implantable delivery devices for long term delivery of drug.Type: GrantFiled: June 13, 1997Date of Patent: June 29, 1999Assignee: ALZA CorporationInventors: Cynthia L. Stevenson, Sally A. Tao, Steven J. Prestrelski, James B. Eckenhoff, deceased, Jeremy C. Wright, John J. Leonard, Jr.
-
Patent number: 5904935Abstract: The present invention provides improved compositions for improving the chemical and physical stability of peptides and proteins. The invention provides a liquid beneficial agent formulation containing a liquid suspension comprising at least 5% by weight beneficial agent and having a viscosity and beneficial agent size which minimizes settling of the agent in suspension over the extended delivery period.Type: GrantFiled: June 7, 1995Date of Patent: May 18, 1999Assignee: ALZA CorporationInventors: James B. Eckenhoff, deceased, Leslie A. Holladay, John Joseph Leonard, Jr., Iris K. M. Leung, Sally A. Tao, Judy A. Magruder, John P. Carr, Jeremy Wright
-
Patent number: 5871770Abstract: A delivery system (10) is disclosed for delivering a fluid-sensitive beneficial agent (7) such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery system comprises a wall that surrounds an internal compartment, said wall comprising a first wall section that limits the passage of fluid into the system and a second wall section that permits the passage of fluid into the system. An exit passageway is provided for delivering the beneficial agent an interior compartment (18) to the animal. The exit passageway is sealed with a wax seal (30) which is expelled through the passageway (13) as the internal pressure within the device (10) reaches a predetermined "bursting" pressure.Type: GrantFiled: October 8, 1997Date of Patent: February 16, 1999Assignee: ALZA CorporationInventors: Judy A. Magruder, James B. Eckenhoff, deceased, Richard Cortese, Jeremy C. Wright, John R. Peery, James B. Pike, Urano A. Robinson, Jonathan P. Smith, Lyle E. Ziemann
-
Patent number: 5731001Abstract: A delivery system is disclosed for delivering a fluid-sensitive active agent such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery system comprises a first wall section, a second wall section and a locking coupling therebetween. The coupled wall sections define a compartment, enclosing an active agent and an expandable driving member. Various embodiments of the locking coupling are disclosed.Type: GrantFiled: June 7, 1995Date of Patent: March 24, 1998Inventors: Judy A. Magruder, James B. Eckenhoff, deceased, Bonnie J. Eckenhoff, Edward V. Bourneuf, Richard Cortese, Jeremy C. Wright, John R. Peery, Ed Bourneuf, James B. Pike, Urano A. Robinson, John M. Sharockman, Jonathan P. Smith
-
Patent number: 5690952Abstract: A delivery system (10) is disclosed for delivering a fluid-sensitive beneficial agent (7) such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery system comprises a wall that surrounds an internal compartment, said wall comprising a first wall section that limits the passage of fluid into the system and a second wall section that permits the passage of fluid into the system. An exit passageway is provided for delivering the beneficial agent an interior compartment (18) to the animal. The exit passageway is sealed with a wax seal (30) which is expelled through the passageway (13) as the internal pressure within the device (10) reaches a predetermined "bursting" pressure.Type: GrantFiled: June 7, 1995Date of Patent: November 25, 1997Assignee: Judy A. Magruder et al.Inventors: Judy A. Magruder, James B. Eckenhoff, deceased, Richard Cortese, Jeremy C. Wright, John R. Peery, James B. Pike, Urano A. Robinson, Jonathan P. Smith, Lyle E. Ziemann
-
Patent number: RE35601Abstract: The present invention is directed to an improved fluid-imbibing dispensing device for delivering a beneficial agent to a biological environment of use, the dispensing device being of the type having a housing which includes a fluid-impermeable first wall section with an open end and a fluid-permeable second wall section with an open end, an internal compartment formed by the first and second wall sections, exit means in the housing, a beneficial agent in that portion of the compartment formed by the first wall section, expandable driving means in that portion of the compartment formed by the second wall section, and a partition layer between the beneficial agent and the expandable driving means; wherein the improvement comprises the first wall section being comprised of an extremely fluid-impermeable material and the open end of each of the first wall section and the second wall section having reciprocally tapered edges one with the other to form a tapered lap joint for mating engagement, the tapered lap joinType: GrantFiled: August 11, 1994Date of Patent: September 2, 1997Assignee: ALZA CorporationInventor: James B. Eckenhoff, deceased