Abstract: The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Abstract: A portable loudspeaker enclosure is made of a collapsible shell of a fabric material, e.g., canvas, having top, bottom, left, right, and back walls. These walls each are each formed of a sandwich of fabric layers and an acoustic insulation layer, such as foamed plastic or glass fiber, the insulation layer being disposed to the inside of the shell. The fabric at each wall forms a pouch co-extensive with the wall. A rigid speaker frame serves as a front wall for the enclosure and is fitted into the front of the enclosure. The frame extends within the shell towards the back wall to a point behind the loudspeaker, i.e., about one-third of the front-to-back dimension. For each wall there is a rigid batt or insert that is dimensioned to fit removably into the pouch. The batts create a rigid cavity behind the loudspeaker. The portable enclosure can have a front cover that removably covers the front wall of the enclosure, i.e., for storage and transit.