Patents by Inventor James B. Hemphill

James B. Hemphill has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Activatable CRISPR/CAS9 for spatial and temporal control of genome editing
    Patent number: 11214779
    Abstract: Disclosed herein is a genetically encoded light- or chemically-activated Cas9 engineered through the site-specific installation of an activatable lysine amino acid. Such activatable Cas9 proteins can be used in CRISPR/Cas9 systems to control gene expression temporally, spatially, or both. Systems, methods, kits, and compositions for manipulation of sequences and/or activities of target sequences are provided. Also provided are methods of directing CRISPR complex formation in cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas9 system.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: January 4, 2022
    Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, The University of North Carolina at Chapel Hill
    Inventors: Alexander Deiters, James B. Hemphill, Aravind Asokan, Erin Borchardt
  • ACTIVATABLE CRISPR/CAS9 FOR SPATIAL AND TEMPORAL CONTROL OF GENOME EDITING
    Publication number: 20180073002
    Abstract: Disclosed herein is a genetically encoded light- or chemically-activated Cas9 engineered through the site-specific installation of an activatable lysine amino acid. Such activatable Cas9 proteins can be used in CRISPR/Cas9 systems to control gene expression temporally, spatially, or both. Systems, methods, kits, and compositions for manipulation of sequences and/or activities of target sequences are provided. Also provided are methods of directing CRISPR complex formation in cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas9 system.
    Type: Application
    Filed: April 8, 2016
    Publication date: March 15, 2018
    Applicants: University of Pittsburgh - Of the Commonwealth Sys tem of Higher Education, The University of North Carolina at Chapel Hill
    Inventors: Alexander Deiters, James B. Hemphill, Aravind Asokan, Erin Borchardt