Patents by Inventor James B. Summers
James B. Summers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7045995Abstract: In one embodiment, an algorithm is employed to calibrate electronic circuitry that is adjustable according to operating parameters. The calibration causes an output component to be substantially nulled. The algorithm includes adjusting at least one of the operating parameters over a plurality of values, applying an input signal to the electronic circuitry concurrently with the adjusting, measuring magnitudes of the output component from the electronic circuitry produced in response to the input signal and the adjusting, wherein the plurality of values are selected such that the magnitudes are not substantially nulled, and providing the magnitudes and the plurality of values to a curve fitting algorithm to calculate a plurality of operating parameters that cause the output component to be substantially nulled.Type: GrantFiled: May 14, 2004Date of Patent: May 16, 2006Assignee: Agilent Technologies, Inc.Inventor: James B. Summers
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Patent number: 6587671Abstract: An RF test set having a concurrent measurement architecture is provided. The RF test set is adapted for testing an RF communications device such as a cellular phone according to a set of RF tests. An RF source and an RF receiver are used to communicate with the cellular phone in order to perform the call processing operations to control the cellular phone while performing parametric measurements according to the RF tests. Concurrent measurements allow operation of concurrent measurement processes and call processing operations to take place in the RF test set in order to decrease the time required for each RF test and to increase measurement throughput of the RF test set.Type: GrantFiled: May 28, 1999Date of Patent: July 1, 2003Assignee: Agilent Technologies, Inc.Inventors: Kerwin D. Kanago, David L. Platt, James B. Summers, Melvin D. Humpherys, Richard P. Ryan, Matthew Johnson
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Patent number: 5952320Abstract: Macrocyclic compounds of formula ##STR1## are potent inhibitors of matrix metalloproteinase and are useful in the treatment of diseases in which matrix metalloproteinase play a role. Also disclosed are matrix metalloproteinase inhibiting compositions and a method of inhibiting matrix metalloproteinase in a mammal.Type: GrantFiled: December 17, 1997Date of Patent: September 14, 1999Assignee: Abbott LaboratoriesInventors: Steven K. Davidsen, Douglas H. Steinman, George S. Sheppard, Lianhong Xu, James H. Holms, Yan Guo, James B. Summers, Alan S. Florjancic, Michael R. Michaelides
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Patent number: 5665777Abstract: Compounds of formula ##STR1## or a pharmaceutically acceptable salt thereof inhibit matrix metalloproteinases and TNF.alpha. secretion and are useful in the treatment of inflammatory disease states. Also disclosed are matrix metalloproteinases and TNF.alpha. secretion inhibiting compositions and a method for inhibiting matrix metalloproteinases and TNF.alpha. secretion.Type: GrantFiled: November 14, 1995Date of Patent: September 9, 1997Assignee: Abbott LaboratoriesInventors: Stephen W. Fesik, James B. Summers, Jr., Steven K. Davidsen, George S. Sheppard, Douglas H. Steinman, George M. Carrera, Jr., Alan Florjancic, James H. Holms
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Patent number: 5654305Abstract: The present invention provides compounds of formula ##STR1## wherein Y is >C.dbd.O or >S(O).sub.t wherein t is 1 or 2 and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, rhinitis, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.Type: GrantFiled: July 2, 1996Date of Patent: August 5, 1997Assignee: Abbott LaboratoriesInventors: George S. Sheppard, Steven K. Davidsen, James B. Summers, George M. Carrera, Jr.
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Patent number: 5643922Abstract: The present invention provides compounds of formula ##STR1## and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, rhinitis, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.Type: GrantFiled: July 2, 1996Date of Patent: July 1, 1997Assignee: Abbott LaboratoriesInventors: George S. Sheppard, Steven K. Davidsen, James B. Summers
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Patent number: 5567711Abstract: The present invention provides compounds of formula ##STR1## and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.Type: GrantFiled: April 19, 1995Date of Patent: October 22, 1996Assignee: Abbott LaboratoriesInventors: George S. Sheppard, Steven K. Davidsen, James B. Summers, George M. Carrera, Jr.
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Patent number: 5486525Abstract: The present invention relates to compounds of formula ##STR1## and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.Type: GrantFiled: December 5, 1994Date of Patent: January 23, 1996Assignee: Abbott LaboratoriesInventors: James B. Summers, Jr., Steven K. Davidsen, Michael L. Curtin, H. Robin Heyman, George S. Sheppard, Lianhong Xu, George M. Carrera, Jr., Robert B. Garland
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Patent number: 5459152Abstract: Indole compounds substituted at the 3-position by a 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]thiazole, 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]oxazole, or 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]pyrrole group are potent antagionists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointesinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.Type: GrantFiled: December 2, 1993Date of Patent: October 17, 1995Assignee: Abbott LaboratoriesInventors: James B. Summers, Steven K. Davidsen, James H. Holms, Daisy Pireh, H. Robin Heyman, Michael B. Martin, Douglas H. Steinman, George S. Sheppard, George M. Carrera, Jr.
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Patent number: 5382670Abstract: Indole compounds substituted at the 1- or 3-position by a (pyrid-3-yl)thiazolid-4-yl)alkyl-, (pyrid-3-yl)thiazolid-4-oyl)-, (pyrid-3-yl)dithiolan-4-yl)alkyl- or (pyrid-3-yl)dithiolan-4-oyl)- group are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including septic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturtition, fetal lung maturation, and cellular differentiation.Type: GrantFiled: July 7, 1993Date of Patent: January 17, 1995Assignee: Abbott LaboratoriesInventors: James B. Summers, George S. Sheppard, James G. Phillips, Daisy Pireh, Douglas H. Steinman, Paul D. May, Denise E. Guinn, H. Robin Heyman, George M. Carrera, Jr., Steven K. Davidsen
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Patent number: 5250565Abstract: Pro-drugs of potent 5-lipoxygenase inhibiting compounds comprise compounds of the formula ##STR1## in which A is an alkylene or alkenylene group, X is oxygen, sulfur, sulfoxyl, or substituted nitrogen, and Y is a group which includes substituted or unsubstituted carbocyclic or substituted or unsubstituted heterocyclic aryl. R.sup.1 is an alkyl, alkenyl, amino, alkylamino, dialkylamino, or hydroxyamino group or an amine group bearing a metabolically cleavable leaving group. M is hydrogen, a pharmaceutically acceptable cation or a metabolically cleavable leaving group, with the proviso that either M or R.sup.1 must bear a metabolically cleavable leaving group.Type: GrantFiled: January 21, 1992Date of Patent: October 5, 1993Assignee: Abbott LaboratoriesInventors: Dee W. Brooks, James B. Summers
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Patent number: 5220059Abstract: Compounds of the formula: ##STR1## wherein R.sub.1 is selected from (1) hydrogen; (2) --NR.sub.2 R.sub.3, --OR.sub.2 or --SR.sub.2 where R.sub.2 and R.sub.3 are independently selected from hydrogen, alkyl, aryl and alkylaryl; and (3) optionally substituted C1-C8 alkyl, C2-C8 alkenyl, arylalkyl or cycloalkyl;Y is selected from sulfur and oxygen;n is an integer selected from 0 and 1;M is hydrogen, a pharmaceutically acceptable cation, or a metabolically cleavable group; andZ is a residue of a non-steroidal antiinflammatory drug of general form Z--COOH;or a pharmaceutically acceptable salt, ester or prodrug thereof,as well as pharmaceutical compositions containing the above compounds and a method for their use as lipoxygenase inhibitors.Type: GrantFiled: April 19, 1990Date of Patent: June 15, 1993Assignee: Abbott LaboratoriesInventors: Dee W. Brooks, Joseph F. Dellaria, Jr., James B. Summers, Jr.
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Patent number: 5185363Abstract: Substituted phenyl, naphthyl, and thienyl N-hydroxy urea compounds form a class of potent inhibitors of 5- and 12-lipoxygenase and are thus useful compounds in the treatment of inflammatory disease states where leukotrienes and other products of lipoxygenase enzyme activity are implicated.Type: GrantFiled: September 30, 1991Date of Patent: February 9, 1993Assignee: Abbott LaboratoriesInventors: Dee W. Brooks, Daniel J. Kerkman, Jonathan G. Martin, Andrew O. Stewart, James B. Summers
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Patent number: 5175183Abstract: Certain N-aryl, N-heteroaryl-, N-arylalkyl-, N-heteroarylalkyl-, N-arylcyclopropyl- and N-heteroaryl-cyclopropyl-N'-hydroxyurea compounds are inhibitors of lipoxygenase enzyme activity and are thus useful agents in treating disease states such as asthma, arthritis, allergy, psoriasis, inflammatory bowel disease, gout, adult respiratory distress syndrome, endotoxin shock, and other inflammatory conditions in which the products of the arachidonic acid cascade are implicated.Type: GrantFiled: July 10, 1991Date of Patent: December 29, 1992Assignee: Abbott LaboratoriesInventors: Dee W. Brooks, James B. Summers, Karen E. Rodriques
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Patent number: 5149704Abstract: Benzoylphenyl derivatives of 2-(3-pyridinyl)-3-alkyl-4-thiazolidinecarboxamide, 2-(3-pyridinyl)-thiazolid-4-ylacetamide, 2-(3-pyridinyl)-4-dithiolanecarboxamide or 2-(3-pyridinyl)dithiolan-4-yl]urea-group are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including anaphylactic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturtition, fetal lung maturation, and cellular differentiation.Type: GrantFiled: May 3, 1991Date of Patent: September 22, 1992Assignee: Abbott LaboratoriesInventors: James B. Summers, Steven K. Davidsen, Douglas H. Steinman, James G. Phillips, Michael B. Martin, Denise E. Guinn
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Patent number: 5120751Abstract: Benzoylphenyl derivatives of 2-(3-pyridinyl)-3-alkyl-4-thiazolidinecarboxamide, 2-(3-pyridinyl)-thiazolid-4-ylacetamide, 2-(3-pyridinyl)-4-dithiolanecarboxamide or 2-(3-pyridinyl)dithiolan-4-yl] urea are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including anaphylactic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturtition, fetal lung maturation, and cellular differentiation.Type: GrantFiled: March 29, 1991Date of Patent: June 9, 1992Assignee: Abbott LaboratoriesInventors: James B. Summers, Douglas H. Steinman, Denise E. Guinn, Steven K. Davidsen, Paul D. May
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Patent number: 5120749Abstract: Indole compounds substituted at the 1- or 3 position by a (pyrid-3 yl)thiazolid-4-yl)alkyl-, (pyrid-3-yl)thiazolid-4-oyl)-, (pyrid-3-yl)dithiolan-4-yl)alkyl- or (pyrid-3-yl) dithiolan-4-ol)- group are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including anaphylactic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturtition, fetal lung maturation, and cellular differentiation.Type: GrantFiled: February 20, 1991Date of Patent: June 9, 1992Assignee: Abbott LaboratoriesInventors: James B. Summers, George S. Sheppard, James G. Phillips, Daisy Pireh, Douglas H. Steinman, Paul D. May
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Patent number: 5112848Abstract: Substituted furan and pyrrole compounds which are useful in inhibiting lipoxygenase enzymes, particularly 5-lipoxygenase.Type: GrantFiled: April 19, 1990Date of Patent: May 12, 1992Assignee: Abbott LaboratoriesInventors: Dee W. Brooks, Bruce P. Gunn, James H. Holms, James B. Summers
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Patent number: 5026729Abstract: Compounds having 5- and 12-lipoxygenase inhibitory activity have the structure ##STR1## where A is straight or branched divalent alkylene of from one to four carbon atoms, R.sub.1 is methyl, amino, or alkylamino of from one to six carbon atoms and the substituent group R.sub.2 is C.sub.1 -C.sub.2 alkyl.The group R.sub.3 is one or more substituents selected from hydrogen, alkyl of from one to six carbon atoms, alkoxy of from one to six carbon atoms, thioalkoxy of from one to six carbon atoms, halogen, cyano, and trihalomethyl, and R.sub.4 is one or more substituents selected from hydrogen, alkyl of from one to six carbon atoms, alkoxy of from one to six carbon atoms, thioalkoxy of from one to six carbon atoms, hydroxy, halogen, cyano, and trihalomethyl, with the proviso that when R.sub.1 is amino and A is >CHCH.sub.3, R.sub.3 and R.sub.4 may not both be hydrogen.The group designated M is hydrogen, a pharmaceutically acceptable cation, or a metabolically cleavable group.Type: GrantFiled: November 2, 1989Date of Patent: June 25, 1991Assignee: Abbott LaboratoriesInventors: Dee W. Brooks, James B. Summers, James H. Holms
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Patent number: 4992464Abstract: Compounds, compositions a method of inhibiting lipoxygenase and treating related disorders are disclosed. The compounds are of the formula:Ar-A(R.sub.2).sub.n -N(OM)-CZ-R.sub.1whereinAr is ##STR1## where X is O, S, SO.sub.2 or NR.sub.3 ;R.sub.3 is hydrogen, alkyl, alkylaryl, alkoyl, alkylakoyl, aroyl or alkylaroyl;Y is hydrogen, halogen, alkyl, alkenyl, cycloalkyl, aryl, arylalkyl, arylalkenyl, --OR, --SR, --COOR, --COR, --CON(R).sub.2, --OCOR, --N(R).sub.2, --O(CH).sub.2, --SO.sub.2 R, --SO.sub.2 N(R).sub.2, --O(CH.sub.2).sub.p OR, --CN, --NO.sub.2, --O(CH).sub.p O(CH.sub.2).sub.p OR or --CF.sub.3 ;R is hydrogen, hydroxyl, alkyl, alkylaryl or aryl;m is 0 to 5;p is 1 to 4;A is C.sub.1 -C.sub.12 alkylene or C.sub.2 -C.sub.14 alkenylene;R.sub.2 is --OR, --SR, --COOR, --COR, --CON(R).sub.2, --OCOR, --N(R).sub.2, --O(CH.sub.2).sub.y CON(R).sub.2, --O(CH.sub.2).sup.y OR, --CN, --NO.sub.2, 1-tetrazolo, C.sub.4 -C.sub.8 cyclic amido, imidazolo, --O(CH.sub.2).sub.y O(CH.sub.2).sub.y OR, --CF.sub.Type: GrantFiled: November 1, 1989Date of Patent: February 12, 1991Assignee: Abbott LaboratoriesInventors: Dee W. Brooks, James B. Summers, Karen E. Rodriques, Robert G. Maki, Joseph F. Dellaria, James H. Holms, Jimmie L. Moore