Abstract: Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides quinazolinone, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders (e.g., migraine, ataxia, Parkinson's disease, bipolar disorders, trigeminal neuralgia, spasticity, mood disorders, brain tumors, psychotic disorders, myokymia, seizures, epilepsy, hearing and vision loss, Alzheimer's disease, age-related memory loss, learning deficiencies, anxiety and motor neuron diseases) and as neuroprotective agents (e.g., to prevent stroke and the like) by modulating potassium channels associated with the onset or recurrence of the indicated conditions.

Abstract: An implantable screw system for maintaining horizontal and/or vertical space during bone grafting procedures is provided, the screw comprising: a contoured head having a region adapted to support soft tissue and permit bone growth; a threaded shaft and a tip adapted to penetrate bone tissue; and where one screw contains a threaded chamber for engaging a second screw for additional space maintenance; wherein the screw(s) comprises cortical bone material. Methods of implanting one or more screws during bone grating procedures are disclosed.

Abstract: Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.

Abstract: Compounds which bind to opioid receptors are provided. In a preferred embodiment of the invention, the compounds are opioid receptor antagonists. The present invention also provides methods of treating conditions which are mediated by an opioid receptor.

Abstract: Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors relative to nor-BNI, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.

Abstract: The present application relates to novel opioid receptor antagonists and agonists, methods of making these compounds, and methods of use thereof.

Abstract: Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides quinazolinone, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders (e.g., migraine, ataxia, Parkinson's disease, bipolar disorders, trigeminal neuralgia, spasticity, mood disorders, brain tumors, psychotic disorders, myokymia, seizures, epilepsy, hearing and vision loss, Alzheimer's disease, age-related memory loss, learning deficiencies, anxiety and motor neuron diseases) and as neuroprotective agents (e.g., to prevent stroke and the like) by modulating potassium channels associated with the onset or recurrence of the indicated conditions.

Abstract: The present application relates to novel opioid receptor antagonists and agonists, methods of making these compounds, and methods of use thereof.

Abstract: The present invention relates to a class of nitrogen-containing heterocyclic compounds which bind to opioid receptors. The inventive compounds can be used to treat a variety of disease states which involve the opioid receptors.

Abstract: The present application relates to novel opioid receptor antagonists and agonists, methods of making these compounds, and methods of use thereof.

Abstract: Structurally novel kappa opioid receptor antagonists are provided and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.

Abstract: The present application relates to novel opioid receptor antagonists and agonists, methods of making these compounds, and methods of use thereof.

Abstract: The present application relates to novel opioid receptor antagonists and agonists, methods of making these compounds, and methods of use thereof.

Abstract: The present application relates to novel opioid receptor antagonists and agonists, methods of making these compounds, and methods of use thereof.

Abstract: The present application relates to novel opioid receptor antagonists and agonists, methods of making these compounds, and methods of use thereof.

Abstract: The present application relates to novel opioid receptor antagonists and agonists, methods of making these compounds, and methods of use thereof.

Abstract: Structurally novel kappa opioid receptor antagonists are provided and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.

Abstract: Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors relative to nor-BNI, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.

Abstract: A tie tucking apparatus for engaging an edge of a segment of a neck tie wrapped around a user shirt collar and for guiding the tie underneath the user shirt collar includes a plate of relatively unyielding material having a tie engaging end including a tie edge engaging slot extending into the plate and defining plate tabs separated by the engaging slot, the plate tabs being spaced apart by the engaging slot. The apparatus preferably additionally includes a collar abutment plate edge, and the collar abutment edge preferably is angled relative to the engaging slot so that the plate narrows at the tie engaging end to fit more easily under a collar. The plate preferably is elongate and has a plate longitudinal axis and two opposing plate longitudinal ends. The engaging slot optionally extends into the plate parallel to the plate longitudinal axis. Each plate longitudinal end preferably is a tie engaging end, so that the plate may be gripped by a user from either plate longitudinal end for use.

Abstract: A pressurized squeeze casting apparatus and method for casting articles includes densifying means for mechanically applying force to a die assembly to compress and densify the molten metal material into a solid article having a near net shape. A shutoff member is provided to seal the interior cavity at the juncture of the runner and the cavity after the cavity is filled with molten metallic material and prior to densification. A low pressure furnace provides a supply of molten metallic material. The outlet from the furnace is biased into engagement with the runner by the gas pressure in the low pressure furnace to ensure a fluid tight connection between the furnace and the runner.