Abstract: The invention concerns compounds of Formula (I): wherein L1, R1, R2, R3, R4 and X are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the treatment of disease, for example cancer.

Abstract: A voice communication device, supporting both Internet and public switched telephone network telephony, performs call session hand off between Internet and public switched telephone networks. Hand off, with or without user confirmation, may be half or full duplex, yielding common and differing incoming and outgoing call session pathways. In addition to mid-call hand offs, hand off may also be performed as part of the call session setup. Information regarding the destination network is exchanged on the network from which the hand off will occur. Voice communication devices are each configured with a plurality of communication interfaces including a public switched telephone network interface and an Internet interface. Basic full-duplex operations include immediate and mid-call hand offs between the public switched telephone network and Internet. Mixed pathway communication and handoffs using partly Internet and partly public switched telephone network are also contemplated.

Abstract: A telephony bridging device operates within infrastructure that includes a packet data network (Internet) and the Public Switched Telephone Network (PSTN) telephony network and supports a coupled POTS telephony device. The telephony bridging device is operable to bridge calls between every two of the POTS telephony device, the PSTN network, and the packet data network (Internet). The telephony bridging device selectively bridges incoming calls to the POTS telephony device, to remote PSTN terminals, and to remote VoIP terminals based upon telephony bridging instructions. These telephony bridging instructions may be stored locally or remotely.