Patents by Inventor James C. Keith, Jr.
James C. Keith, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7531564Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R2a, R3, R3a, and R4, and X as defined in the specification, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: December 11, 2006Date of Patent: May 12, 2009Assignee: WyethInventors: Michael S. Malamas, Robert E. McDevitt, Iwan Gunawan, Eric S. Manas, Michael D. Collini, Heather A. Harris, James C. Keith, Jr., Leo M. Albert, C. Richard Lyttle
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Patent number: 7235539Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein, R1 is hydrogen, alkyl of 1–6 carbon atoms, benzyl, alkylcarbonyl of 2–7 carbon atoms, or benzoyl; X is R2 is hydrogen, alkyl of 1–6 carbon atoms, benzyl, alkylcarbonyl of 2–7 carbon atoms, or benzoyl; R3 is hydrogen, alkyl of 1–6 carbon atoms, hydroxy, or alkoxy of 1–6 carbon atoms; a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable salt of a sulfate ester of the hydroxyl group at the 3- or 17-position when R1 or R2 is hydrogen, or a glucuronide of the hydroxyl group at the 3- or 17-position when R1 or R2 is hydrogen.Type: GrantFiled: January 21, 2003Date of Patent: June 26, 2007Assignee: WyethInventors: Heather A. Harris, James C. Keith, Jr., Leo M. Albert, Galina Vid, Sreenivasulu Megati, Christopher P. Miller
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Patent number: 7148247Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R2a, R3, R3a, and R4, and X as defined in the specification, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: May 17, 2004Date of Patent: December 12, 2006Assignee: WyethInventors: Michael S Malamas, Robert E McDevitt, Iwan Gunawan, Eric S Manas, Michael D Collini, Heather A Harris, James C Keith, Jr., Leo M Albert, Cecil Richard Lyttle
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Patent number: 7067524Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10, are as defined in the specification, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: March 18, 2004Date of Patent: June 27, 2006Assignee: WyethInventors: Richard E. Mewshaw, Richard J. Edsall, Cuijian Yang, Heather A. Harris, James C. Keith, Jr., Leo M. Albert, Eric S. Manas
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Patent number: 7022733Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R, R?, A, A?, X, Y, and Y are as defined in the specification, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: April 21, 2004Date of Patent: April 4, 2006Assignee: WyethInventors: Christopher P. Miller, Michael D. Collini, David H. Kaufman, Robert L. Morris, Robert R. Singhaus, Jr., John W. Ullrich, Heather A. Harris, James C. Keith, Jr., Leo M. Albert, Rayomand J. Unwalla
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Patent number: 6960607Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R3, and R4, and X as defined in the specification, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: December 11, 2002Date of Patent: November 1, 2005Assignee: WyethInventors: Michael S. Malamas, Iwan Gunawan, Heather A. Harris, James C. Keith, Jr., Leo M. Albert
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Patent number: 6914074Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10, are as defined in the specification, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: December 11, 2002Date of Patent: July 5, 2005Assignee: WyethInventors: Richard E. Mewshaw, Richard J. Edsall, Cuijian Yang, Heather A. Harris, James C. Keith, Jr., Leo M. Albert, Eric S. Manas
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Patent number: 6903238Abstract: This invention provides estrogen receptor modulators of formula I, having the structure R1, R2, and R3 are as defined in the specification, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: December 11, 2002Date of Patent: June 7, 2005Assignee: WyethInventors: Robert E. McDevitt, Folake O. Adebi, Heather A. Harris, James C. Keith, Jr., Leo M. Albert
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Patent number: 6887461Abstract: Provided by the present invention are topical formulations of Interleukin-11 and methods for treating a variety of disorders, including inflammatory bowel diseases (e.g., Crohn's disease, ulcerative colitis, indeterminate colitis, and infectious colitis), mucositis (e.g., oral mucositis, gastrointestinal mucositis, nasal mucositis, and proctitis), necrotizing enterocolitis, inflammatory skin disorders (e.g., psoriasis, atopic dermatitis, and contact hypersensitivity), aphthous ulcers, pharyngitis, esophagitis, peptic ulcers, gingivitis, periodontitis, and ocular diseases (e.g., conjunctivitis, retinitis, and uveitis).Type: GrantFiled: June 27, 2000Date of Patent: May 3, 2005Assignee: Genetics Institute, LLCInventors: Nick W. Warne, Camille L. Bedrosian, James C. Keith, Jr., Ullrich S. Schwertschlag, Paul F. Schendel
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Patent number: 6884814Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein, R1, R2, and R3 are as defined in the specification, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: December 11, 2002Date of Patent: April 26, 2005Assignee: WyethInventors: Michael S. Malamas, Tam Q. Dinh, Iwan Gunawan, Michael D. Collini, Heather A. Harris, James C. Keith, Jr., Leo M. Albert
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Patent number: 6835745Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein, R1, R2, R3, X, and Y are as defined in the specification, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: January 10, 2003Date of Patent: December 28, 2004Assignee: WyethInventors: Richard D. Coghlan, William F. Fobare, Heather A. Harris, James C. Keith, Jr., Leo M. Albert
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Patent number: 6774248Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R, R′, A, A′, X, Y, and Y are as defined in the specification, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: December 16, 2002Date of Patent: August 10, 2004Assignee: WyethInventors: Christopher P. Miller, Michael D. Collini, David H. Kaufman, Robert L. Morris, Robert R. Singhaus, Jr., John W. Ullrich, Heather A. Harris, James C. Keith, Jr., Leo M. Albert, Rayomand J. Unwalla
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Patent number: 6723314Abstract: The use of interleukin-11 to prevent, to ameliorate, and to treat a gastrointestinal disorder in a mammal in need of such treatment is disclosed.Type: GrantFiled: August 1, 2001Date of Patent: April 20, 2004Assignees: Genetics Institute, LLC, Catholic UniversityInventors: James C. Keith, Jr., Theo L. Peeters, Inge Depoortere, G. Van Asche
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Patent number: 6723747Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R3, R4 R5, R6, and R7 are as defined in the specification, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: December 11, 2002Date of Patent: April 20, 2004Assignee: WyethInventors: Richard E. Mewshaw, Richard J. Edsall, Stephen T. Cohn, Heather A. Harris, James C. Keith, Jr., Leo M. Albert
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Patent number: 6589980Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein X, Y1, Y2, Y3, Y4, Z1, Z2, Z3, and Z4 are as defined in the specification, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: May 15, 2002Date of Patent: July 8, 2003Assignee: WyethInventors: Christopher P. Miller, Michael D. Collini, Heather A. Harris, James C. Keith, Jr.
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Patent number: 6559177Abstract: This invention provides estrogen receptor modulators of formula 1, having the structure wherein X, Y1, Y2, Y3, Y4, Z1, Z2, Z3, and Z4 are as defined in the specification, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: April 15, 2002Date of Patent: May 6, 2003Assignee: WyethInventors: Christopher P. Miller, Michael D. Collini, Heather A. Harris, James C. Keith, Jr.
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Patent number: 6540993Abstract: Provided by the present invention are topical formulations of Interleukin-11 and methods for treating a variety of disorders, including inflammatory bowel diseases (e.g., Crohn's disease, ulcerative colitis, indeterminate colitis, and infectious colitis), mucositis (e.g., oral mucositis, gastrointestinal mucositis, nasal mucositis, and proctitis), necrotizing enterocolitis, inflammatory skin disorders (e.g., psoriasis, atopic dermatitis, and contact hypersensitivity), aphthous ulcers, pharyngitis, esophagitis, peptic ulcers, gingivitis, periodontitis, and ocular diseases (e.g., conjunctivitis, retinitis, and uveitis).Type: GrantFiled: September 15, 2000Date of Patent: April 1, 2003Assignee: WyethInventors: Nicholas W. Warne, Camille L. Bedrosian, James C. Keith, Jr., Ullrich S. Schwerschlag, Paul F. Schendel
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Patent number: 6126933Abstract: Provided by the present invention are topical formulations of Interleukin-11 and methods for treating a variety of disorders, including inflammatory bowel diseases (e.g., Crohn's disease, ulcerative colitis, indeterminate colitis, and infectious colitis), mucositis (e.g., oral mucositis, gastrointestinal mucositis, nasal mucositis, and proctitis), necrotizing enterocolitis, inflammatory skin disorders (e.g., psoriasis, atopic dermatitis, and contact hypersensitivity), aphthous ulcers, pharyngitis, esophagitis, peptic ulcers, gingivitis, periodontitis, and ocular diseases (e.g., conjunctivitis, retinitis, and uveitis).Type: GrantFiled: October 26, 1998Date of Patent: October 3, 2000Assignee: Genetics InstituteInventors: Nick W. Warne, Camille L. Bedrosian, James C. Keith, Jr., Ullrich S. Schwertschlag, Paul F. Schendel