Patents by Inventor James C Powers
James C Powers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140134018Abstract: The systems and compressors for use with flammable refrigerants can include features that can reduce or address the generation of sparks or arcs internal or external to the compressor that could ignite the flammable refrigerant. The systems and compressors can also include features that can reduce or address leakage into or out of the hermetic compressor shell which could create a flammable atmosphere that could be ignited if the flammable atmosphere came into contact with an ignition source.Type: ApplicationFiled: November 15, 2013Publication date: May 15, 2014Inventors: John W. TOLBERT, JR., Scott G. HIX, Larry G. PIPPIN, Michael KAUL, James C. POWERS
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Patent number: 8518885Abstract: A novel class of peptide ?-ketoamides useful for selectively inhibiting calpains, selectively inhibiting cysteine proteases, and generally inhibiting all cysteine proteases, having the formula M-AA2-AA1-CO—NH—(CH2)n—R3. Processes for the synthesis of peptidyl ?-ketoamide derivatives. Compositions and methods for inhibiting cysteine proteases, inhibiting calpains, and treating disease caused by cysteine proteases and calpains are provided.Type: GrantFiled: July 16, 2008Date of Patent: August 27, 2013Assignees: Georgia Tech Research Corporation, Emory UniversityInventors: James C. Powers, Jonathan D. Glass, Asli Ovat, Zhaozhao Li
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Patent number: 8033053Abstract: A security barrier apparatus which may be used in conjunction with an existing security gate or may be used as a stand-alone security barrier gate. The system uses a passive restraining device comprising a bollard having at least one catch horn extending therefrom which engages a corresponding structure on the gate to restrain the gate when impacted.Type: GrantFiled: January 27, 2006Date of Patent: October 11, 2011Assignee: Performance Development CorporationInventors: Joe W. Anderson, Victor J. Kaminsky, Thomas A. Lancaster, III, Douglas J. Hornstra, Michael W. Light, James C. Powers, Richard W. Schenk
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Patent number: 8013014Abstract: Methods for treatment and/or prevention of nerve degeneration in mammals using aza-peptide epoxide caspase inhibitors are provided. Aspects of the present disclosure include aza-peptide epoxide compositions to treat or prevent diseases, for example stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, neuropathies, Huntington's disease, dentatorubropallidoluysian atrophy, spinocerebellar atrophies, spinal bulbar muscular atrophy, diabetes, amyotrophic lateral sclerosis and other motor neuron diseases. The disclosed methods can be used in combination with calpain inhibitors to treat disease or pathological conditions related to the activity of caspases and calpain associated with a specific disease or condition.Type: GrantFiled: January 24, 2006Date of Patent: September 6, 2011Assignee: Georgia Tech Research CorporationInventors: James C. Powers, Jonathan D. Glass
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Publication number: 20110053858Abstract: A novel class of peptide ?-ketoamides useful for selectively inhibiting calpains, selectively inhibiting cysteine proteases, and generally inhibiting all cysteine proteases, having the formula M-AA2-AA1-CO—NH—(CH2)n—R3. Processes for the synthesis of peptidyl ?-ketoamide derivatives.Type: ApplicationFiled: July 16, 2008Publication date: March 3, 2011Inventors: James C. Powers, Jonathan D. Glass, Asli Ovat, Zhaozhao Li
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Patent number: 7521427Abstract: The present disclosure provides compositions for inhibiting proteases, methods for synthesizing the compositions, and methods of using the disclosed protease inhibitors. Aspects of the disclosure include peptidyl allyl sulfone compositions that inhibit proteases, for example cysteine proteases, either in vivo or in vitro.Type: GrantFiled: November 9, 2005Date of Patent: April 21, 2009Assignee: Georgia Tech Research CorporationInventors: James C. Powers, Marion Gabriele Gotz
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Patent number: 7482379Abstract: The present disclosure provides compositions for inhibiting proteases, methods for synthesizing the compositions, and methods of using the disclosed protease inhibitors. Aspects of the disclosure include a peptidyl propenoyl hydrazide compositions that inhibit proteases, for example cysteine proteases, either in vivo or in vitro.Type: GrantFiled: February 18, 2005Date of Patent: January 27, 2009Assignee: Georgia Tech Research CorporationInventors: James C. Powers, Juliana Asgian, Özlem Dogan Ekici, Marion Gabriele Gotz, Karen Ellis James, Zhao Zhao Li, Brian Rukamp
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Patent number: 7429560Abstract: Compositions and methods for treating neural pathologies are provided. In particular, compositions and methods for treating neural pathologies including axonal degeneration are provided. The compositions include peptide ?-ketomides optionally in combination with a second therapeutic agent. Another aspect of the invention provides compositions and methods for treating hyperproliferative disorders. Exemplary compositions for treating hyperproliferative disorders include an anti-proliferative agent such as paclitaxel, in combination with a calpain inhibitor such as AK295.Type: GrantFiled: September 25, 2003Date of Patent: September 30, 2008Assignees: Georgia Tech Research Corporation, Emory UniversityInventors: James C. Powers, Jonathan D. Glass
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Patent number: 7056947Abstract: The present invention provides compositions for inhibiting proteases, methods for synthesizing the compositions, and methods of using the disclosed protease inhibitors. Aspects of the invention include aza-peptide epoxide compositions that inhibit proteases, for example cysteine proteases, either in vivo or in vitro. The disclosed compounds, pharmaceutically acceptable salts, pharmaceutically acceptable derivatives, prodrugs, or combinations thereof can be used to treat disease or pathological conditions related to the activity of proteases associated with a specific disease or condition. Such treatable conditions include viral infections, stroke, neurodegenerative disease, and inflammatory disease, among others.Type: GrantFiled: June 24, 2003Date of Patent: June 6, 2006Assignee: Georgia Tech Research Corp.Inventors: James C. Powers, Juliana L. Asgian, Karen E. James, Zhao-Zhao Li
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Publication number: 20040127427Abstract: Compositions and methods for treating neural pathologies are provided. In particular, compositions and methods for treating neural pathologies including axonal degeneration are provided. The compositions include peptide &agr;-ketomides optionally in combination with a second therapeutic agent. Another aspect of the invention provides compositions and methods for treating hyperproliferative disorders. Exemplary compositions for treating hyperproliferative disorders include an anti-proliferative agent such as paclitaxel, in combination with a calpain inhibitor such as AK295.Type: ApplicationFiled: September 25, 2003Publication date: July 1, 2004Inventors: James C. Powers, Jonathan D. Glass
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Publication number: 20040048327Abstract: The present invention provides compositions for inhibiting proteases, methods for synthesizing the compositions, and methods of using the disclosed protease inhibitors. Aspects of the invention include aza-peptide epoxide compositions that inhibit proteases, for example cysteine proteases, either in vivo or in vitro. The disclosed compounds, pharmaceutically acceptable salts, pharmaceutically acceptable derivatives, prodrugs, or combinations thereof can be used to treat disease or pathological conditions related to the activity of proteases associated with a specific disease or condition. Such treatable conditions include viral infections, stroke, neurodegenerative disease, and inflammatory disease, among others.Type: ApplicationFiled: June 24, 2003Publication date: March 11, 2004Inventors: James C. Powers, Juliana L. Asgian, Karen E. James, Zhao-Zhao Li
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Patent number: 6235929Abstract: A novel class of tripeptide &agr;-ketoamides useful for selectively inhibiting serine proteases, selectively inhibiting cysteine proteases, generally inhibiting all serine proteases, and generally inhibiting all cysteine proteases, having the formula M1—AA—AA—AA—CO—NR3R4.Type: GrantFiled: December 27, 1996Date of Patent: May 22, 2001Assignee: Georgia Tech Research CorporationInventor: James C Powers
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Patent number: 5952307Abstract: Peptidyl derivatives of diesters of .alpha.-aminoalkylphosphonic acids with basic substituents, their use in inhibiting serine proteases with trypsin-like specificity and their roles as anti-inflammatory agents, anticoagulants, and anti-tumor agents.Type: GrantFiled: August 14, 1997Date of Patent: September 14, 1999Assignee: Georgia Tech Research Corp.Inventors: James C. Powers, Delwin S. Jackson, Liming Ni
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Patent number: 5916877Abstract: Fluorescent 1-peptidylaminoalkanephosphonate derivatives, and their use in detecting and studying the distribution of serine proteases in cells and biological systems.Type: GrantFiled: August 14, 1997Date of Patent: June 29, 1999Assignee: Georgia Tech Research CorporationInventors: James C. Powers, Shin Ono
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Patent number: 5763576Abstract: A novel class of tetrapeptide .alpha.-ketoamides useful for selectively inhibiting serine proteases, selectively inhibiting cysteine proteases, generally inhibiting all serine proteases, and generally inhibiting all cysteine proteases, having the formula M.sub.1 --AA.sup.1 --AA.sup.2 --AA.sup.3 --AA.sup.4 --CO--NR.sub.3 R.sub.4.Type: GrantFiled: December 27, 1996Date of Patent: June 9, 1998Assignee: Georgia Tech Research Corp.Inventor: James C. Powers
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Patent number: 5726314Abstract: Novel quaternary pyridinium compounds useful in inhibiting acetylcholinesterase in mammals of the general structure: ##STR1## or pharmaceutically acceptable salts thereof, where R.sub.5 is pentafluorophenyl, phenyl monosubstituted with K, phenyl disubstituted with K, phenyl trisubstituted with K, or naphthyl; R.sub.6 is H, C.sub.1-6 alkyl, phenyl, pentafluorophenyl, phenyl mono, di, or trisubstituted with K, C.sub.1-6 alkyl with an attached phenyl group, C.sub.1-6 alkyl with an attached phenyl group mono, di, or trisubstituted with K; K is halogen, COOH, OH, CN, NO.sub.2, NH.sub.2, C.sub.1-6 alkyl, C.sub.1-6 fluorinated alkyl, C.sub.1-6 alkoxy, C.sub.1-6 alkylamine, C.sub.1-6 alkyl--O--CO--, C.sub.1-6 alkyl--CO--NH--, C.sub.1-6 alkyl--NH--CO--NH--, C.sub.1-6 alkyl--NH--CO--O--, C.sub.1-6 alkyl--NH--CO--, or (C.sub.1-6 alkyl).sub.2 N--CO--; X is OH, C.sub.1-6 alkyl--NH--CO--O--, (C.sub.1-6 alkyl).sub.2 --N--CO--O--, C.sub.1-6 fluoroalkyl--NH--CO--, or (C.sub.1-6 fluoroalkyl).sub.Type: GrantFiled: September 30, 1996Date of Patent: March 10, 1998Assignee: Georgia Tech Research Corp.Inventors: James C. Powers, Jerry J. Buccafusco, Kenneth M. Starks
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Patent number: 5714615Abstract: Methods for using novel quaternary pyridinium compounds in inhibiting acetylcholinesterase in mammals, specifically using the quaternary pyridinium compounds in the prophylaxis and treatment of organophosphate poisoning and mammalian dementia by mimicking or opposing the actions of the natural neurotransmitter acetylcholine.Type: GrantFiled: February 8, 1994Date of Patent: February 3, 1998Assignee: Georgia Tech Research CorporationInventors: James C. Powers, Jerry J. Buccafusco, Kenneth M. Starks
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Patent number: 5686419Abstract: Peptidyl derivatives of diesters of .alpha.-aminoalkylphosphonic acids with basic substitutents, their use in inhibiting serine proteases with trypsin-like specificity and their roles as anti-inflammatory agents, anticoagulants, and anti-tumor agents.Type: GrantFiled: January 21, 1994Date of Patent: November 11, 1997Assignee: Georgia Tech Research Corp.Inventors: James C. Powers, Bogdan Boduszek, Jozef Oleksyszyn
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Patent number: 5681821Abstract: Fluorescent 1-peptidylaminoalkanephosphonate derivatives, and their use in detecting and studying the distribution of serine proteases in cells and biological systems.Type: GrantFiled: October 18, 1994Date of Patent: October 28, 1997Assignee: Georgia Tech Research Corp.Inventors: James C. Powers, Ahmed S. Abuelyaman
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Patent number: 5650508Abstract: A novel class of peptide .alpha.-ketoamides useful for selectively inhibiting serine proteases, selectively inhibiting cysteine proteases, generally inhibiting all serine proteases, and generally inhibiting all cysteine proteases, having the formula M.sub.1 --AA--NH--CHR.sub.2 --CO--CO--NR.sub.3 R.sub.4, M.sub.1 --AA.sub.2 --AA.sub.1 --CO--NR.sub.3 R.sub.4, M.sub.1 --AA--AA--AA--CO--NR.sub.3 R.sub.4, M.sub.1 --AA--AA--AA--AA--CO--NR.sub.3 R.sub.4, or M.sub.1 --AA--CO--NR.sub.3 R.sub.4.Type: GrantFiled: October 6, 1995Date of Patent: July 22, 1997Assignee: Georgia Tech Research CorporationInventor: James C. Powers