Abstract: Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40 and comprise improved heavy and light chain variable regions that impart improved yield and reduced aggregation. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.

Abstract: The invention relates to a cementing tool for use in oil and gas well decommissioning operations, in particular so called perforate, wash and cement procedures. The tool (1) is designed for running in a well on drill string and for jetting cement through previously formed perforations in the casing (10) to fill the outer annulus (9) with cement. The tool (1) has a cylindrical wall (3) which is formed from steel (11) and elastomeric (5) elements, whereby it is expandable between a first diameter in which it may be run down the well and a second, larger diameter deployed during cementing operations. (FIG. 2).

Abstract: The invention relates to a cementing tool for use in oil and gas well decommissioning operations, in particular so called perforate, wash and cement procedures. The tool (1) is designed for running in a well on drill string and for jetting cement through previously formed perforations in the casing (10) to fill the outer annulus (9) with cement. The tool (1) has a cylindrical wall (3) which is formed from steel (11) and elastomeric (5) elements, whereby it is expandable between a first diameter in which it may be run down the well and a second, larger diameter deployed during cementing operations.

Abstract: The invention relates to a method of conducting a perf wash cement (“P/W/C”) abandonment job in an offshore oil or gas well annulus, in particular the washing or cementing operation using a rotating head with nozzles dispensing wash fluid or cement at pressure. A new design of bottom hole assembly is proposed in which the cementing tool has a relatively large diameter in order to optimize pressure whilst the wash tool has a relatively small diameter. The wash process, for a number of reasons, appears to be less sensitive to tool diameter and making the wash tool smaller reduces the overall risk of stuck pipe.

Abstract: The invention relates to a method of conducting a perf wash cement (“P/W/C”) abandonment job in an offshore oil or gas well annulus (2), in particular the washing or cementing operation using a rotating head (6, 8) with nozzles (7, 9) dispensing wash fluid or cement at pressure. Certain values of parameters of a washing or cementing job have been found surprisingly to affect the quality of the job, or the degree to which they affect the quality of the job has been unexpected. These include including rotation rate of the tool, the direction of translational movement of the tool, and the volume flow rate and pressure per nozzle of cement or wash fluid (and hence nozzle size).

Abstract: The invention relates to a method of conducting a perf wash cement (“P/W/C”) abandonment job in an offshore oil or gas well annulus, in particular the washing or cementing operation using a rotating head with nozzles dispensing wash fluid or cement at pressure. A new design of bottom hole assembly is proposed in which the cementing tool has a relatively large diameter in order to optimize pressure whilst the wash tool has a relatively small diameter. The wash process, for a number of reasons, appears to be less sensitive to tool diameter and making the wash tool smaller reduces the overall risk of stuck pipe.

Abstract: The invention relates to a method of conducting a perf wash cement (“P/W/C”) abandonment job in an offshore oil or gas well annulus (2), in particular the washing or cementing operation using a rotating head (6, 8) with nozzles (7, 9) dispensing wash fluid or cement at pressure. Certain values of parameters of a washing or cementing job have been found surprisingly to affect the quality of the job, or the degree to which they affect the quality of the job has been unexpected. These include including rotation rate of the tool, the direction of translational movement of the tool, and the volume flow rate and pressure per nozzle of cement or wash fluid (and hence nozzle size).

Abstract: The invention relates to a cementing tool for use in oil and gas well decommissioning operations, in particular so called perforate, wash and cement procedures. The tool (1) is designed for running in a well on drill string and for jetting cement through previously formed perforations in the casing (10) to fill the outer annulus (9) with cement. The tool (1) has a cylindrical wall (3) which is formed from steel (11) and elastomeric (5) elements, whereby it is expandable between a first diameter in which it may be run down the well and a second, larger diameter deployed during cementing operations. (FIG. 2).

Abstract: The invention relates to a cementing tool (1) and method for setting a cement plug. Instead of the conventional “balanced plug”, the technique involves pumping cement whilst pulling and rotating the tool. The cementing tool (1) includes nozzles (9) for jetting cement which are located in a relatively narrow region (8) of the tool and a larger diameter choke region (5) proximal of the nozzles (9). The end of the tool (11) is closed off and tapered. The tool is passed down the well to a location where it is desired to set a plug, then cement is injected whilst rotating and withdrawing the tool. The jets of cement help displace existing fluid in the well thereby reducing mixing of the existing fluid with the cement, The choke region (5) increases the flow energy, whilst the tapered end (11) helps prevent disruption to the cement as the tool is withdrawn.

Abstract: The invention relates to a method of conducting a perf wash cement (“P/W/C”) abandonment job in an offshore oil or gas well annulus, in particular the washing or cementing operation using a rotating head with nozzles dispensing wash fluid or cement at pressure. A new design of bottom hole assembly is proposed in which the cementing tool has a relatively large diameter in order to optimize pressure whilst the wash tool has a relatively small diameter. The wash process, for a number of reasons, appears to be less sensitive to tool diameter and making the wash tool smaller reduces the overall risk of stuck pipe.

Abstract: The invention relates to a method of conducting a perf wash cement (“P/W/C”) abandonment job in an offshore oil or gas well annulus (2), in particular the washing or cementing operation using a rotating head (6, 8) with nozzles (7, 9) dispensing wash fluid or cement at pressure. Certain values of parameters of a washing or cementing job have been found surprisingly to affect the quality of the job, or the degree to which they affect the quality of the job has been unexpected. These include including rotation rate of the tool, the direction of translational movement of the tool, and the volume flow rate and pressure per nozzle of cement or wash fluid (and hence nozzle size).

Abstract: The invention relates to a method of conducting a perf wash cement (“P/W/C”) abandonment job in an offshore oil or gas well annulus (2), in particular the washing or cementing operation using a rotating head (6, 8) with nozzles (7, 9) dispensing wash fluid or cement at pressure. Certain values of parameters of a washing or cementing job have been found surprisingly to affect the quality of the job, or the degree to which they affect the quality of the job has been unexpected. These include including rotation rate of the tool, the direction of translational movement of the tool, and the volume flow rate and pressure per nozzle of cement or wash fluid (and hence nozzle size).

Abstract: The invention relates to a method of conducting a perf wash cement (“P/W/C”) abandonment job in an offshore oil or gas well annulus (2), in particular the washing or cementing operation using a rotating head (6, 8) with nozzles (7, 9) dispensing wash fluid or cement at pressure. Certain values of parameters of a washing or cementing job have been found surprisingly to affect the quality of the job, or the degree to which they affect the quality of the job has been unexpected. These include including rotation rate of the tool, the direction of translational movement of the tool, and the volume flow rate and pressure per nozzle of cement or wash fluid (and hence nozzle size).

Abstract: A light splitting optical module that converts incident light into electrical energy, the module including a solid optical element comprising an input end for receiving light, a first side, and a second side spaced from the first side, a first solar cell adjacent to the first side of the solid optical element, and a second solar cell adjacent to the second side of the solid optical element. The first solar cell is positioned to absorb a first subset of incident light and reflect a first remainder of the incident light to the second solar cell through the solid optical element, wherein the first solar cell has a lower band gap than the second cell.

Abstract: The present invention provides methods for using single source organometallic precursors in the fabrication of polycrystalline Group III-Group V compounds, preferably semiconductor compounds. The present invention teaches how to select organometallic ligands in single-source precursors in order to control the stoichiometry of the corresponding Group III-Group V compounds derived from these precursors. The present invention further teaches how to anneal precursors in the presence of one or more flux agents in order to increase the crystalline grain size of polycrystalline Group III-Group V compounds derived from organometallic precursors. This helps to provide Group III-Group V semiconductors with better electronic properties. The flux layer also helps to control the stoichiometry of the Group III-Group V compounds.

Abstract: A composition for use in forming a multi-block copolymer, said copolymer containing therein two or more segments or blocks differing in chemical or physical properties, a polymerization process using the same, and the resulting polymers, wherein the composition comprises the admixture or reaction product resulting from combining: (A) a first metal complex olefin polymerization catalyst, (B) a second metal complex olefin polymerization catalyst capable of preparing polymers differing in chemical or physical properties from the polymer prepared by catalyst (A) under equivalent polymerization conditions, and (C) a chain shuttling agent.

Abstract: A photovoltaic system that converts incident light into electrical energy that includes a light trapping optical module having a light randomizing dielectric slab with a first surface and a second surface, a first cell adjacent to the first surface of the slab that has a bandgap of lower energy than the energy of absorption onset of the dielectric slab, at least one filter element in optical contact with the second surface of the dielectric slab, and a sub-cell array with a plurality of photovoltaic sub-cells, wherein at least one of the sub-cells has a first surface that is in optical contact with the at least one filter element.

Abstract: A composition comprising a phase separated block copolymer and an inorganic dielectric nanoparticle, wherein the nanoparticle is dispersed in the copolymer and is present primarily in one phase. For example, a Ti02 nanocomposite can be created via the in situ formation of Ti02 within a silane-grafted OBC. Taking advantage of the phase morphology of the OBC and the differential swelling of the hard and soft segments, due to their inherent crystallinity, enables the selective incorporation of Ti02 nanoparticles into the soft segments of the OBC.

Abstract: The present invention provides strategies for improving the quality of the insulating layer in MIS and SIS devices in which the insulator layer interfaces with at least one pnictide-containing film The principles of the present invention are based at least in part on the discovery that very thin (20 nm or less) insulating films comprising a chalcogenide such as i-ZnS are surprisingly superior tunnel barriers in MIS and SIS devices incorporating pnictide semiconductors. In one aspect, the present invention relates to a photovoltaic device, comprising: a semiconductor region comprising at least one pnictide semiconductor; an insulating region electrically coupled to the semiconductor region, wherein the insulating region comprises at least one chalcogenide and has a thickness in the range from 0.5 nm to 20 nm; and a rectifying region electrically coupled to the semiconductor region in a manner such that the insulating region is electrically interposed between the collector region and the semiconductor region.

Abstract: A light splitting optical module that converts incident light into electrical energy, the module including a solid optical element comprising an input end for receiving light, a first side, and a second side spaced from the first side, a first solar cell adjacent to the first side of the solid optical element, and a second solar cell adjacent to the second side of the solid optical element. The first solar cell is positioned to absorb a first subset of incident light and reflect a first remainder of the incident light to the second solar cell through the solid optical element.