Patents by Inventor James Cali

James Cali has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BIOLUMINESCENT DETECTION OF DNA SYNTHESIS
    Publication number: 20220396830
    Abstract: Provided herein are reagents and methods for incorporating modified nucleotides into DNA and detecting DNA synthesis. In particular, haloalkyl-modified nucleobases are provided for incorporation into nucleic acids for detection by bioluminescent binding agents.
    Type: Application
    Filed: May 13, 2022
    Publication date: December 15, 2022
    Inventors: Wenhui Zhou, Hui Wang, Min Zhou, Natasha Karassina, James Cali, Jolanta Vidugiriene
  • Luminogenic and fluorogenic compounds and methods to detect molecules or conditions
    Publication number: 20070015790
    Abstract: A method to detect the presence or amount of at least one molecule in a sample which employs a derivative of luciferin or a derivative of a fluorophore is provided.
    Type: Application
    Filed: May 31, 2006
    Publication date: January 18, 2007
    Inventors: James Cali, William Daily, Erika Hawkins, Dieter Klaubert, Jianquan Liu, Poncho Meisenheimer, Michael Scurria, John Shultz, James Unch, Michael Valley, Keith Wood, Wenhui Zhou
  • Luminescent ATP detection with extended linearity
    Publication number: 20060234323
    Abstract: A luminescent assay capable of detecting a wider range of ATP concentrations is provided.
    Type: Application
    Filed: April 18, 2005
    Publication date: October 19, 2006
    Inventors: James Cali, Dongping Ma
  • Luciferase-based assays
    Publication number: 20050026171
    Abstract: A method and kit is provided for enhancing the tolerance of an assay reagent to compounds in an assay sample, the assay reagent including a luciferase enzyme. The method includes contacting the luciferase with a tolerance enhancement agent in an amount sufficient to substantially protect luciferase enzyme activity from interference of the compound and minize interference by at least about 10% relative to an assay not having tolerance enhancement agent.
    Type: Application
    Filed: December 23, 2003
    Publication date: February 3, 2005
    Inventors: Erika Hawkins, James Cali, Samuel Ho, Martha O'Brien, Richard Somberg, Robert Bulleit, Keith Wood