Patents by Inventor James Capper
James Capper has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10597691Abstract: Provided herein are methods and kits for isothermal nucleic acid amplifications that use a target nucleic acid template; a reaction mixture comprising a DNA polymerase having a strand displacement activity, a deoxyribonucleoside triphosphate (dNTP) mixture, a primer with a 3? end and a 5? end, a molecular crowding reagent, and a buffer solution for amplifying the target nucleic acid template. The buffer solution maintains a low salt concentration of the reaction mixture, and wherein the salt concentration results in a melting temperature (Tm) of the primer at least 10° C. below the reaction temperature. The amplification is effected under isothermal condition.Type: GrantFiled: January 18, 2017Date of Patent: March 24, 2020Assignee: General Electric CompanyInventors: Ryan Charles Heller, John Richard Nelson, Paresh Lakhubhai Patel, Alison Myfanwy Wakefield, Stephen James Capper
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Patent number: 10443094Abstract: Provided herein are methods and kits for isothermal nucleic acid amplifications that use a target nucleic acid template; a reaction mixture comprising a DNA polymerase having a strand displacement activity, a deoxyribonucleoside triphosphate (dNTP) mixture, a primer with a 3? end and a 5? end, a molecular crowding reagent, and a buffer solution for amplifying the target nucleic acid template. The buffer solution maintains a low salt concentration of the reaction mixture, and wherein the salt concentration results in a melting temperature (Tm) of the primer at least 10° C. below the reaction temperature. The amplification is effected under isothermal condition.Type: GrantFiled: January 30, 2017Date of Patent: October 15, 2019Assignee: General Electric CompanyInventors: Ryan Charles Heller, John Richard Nelson, Paresh Lakhubhai Patel, Alison Myfanwy Wakefield, Stephen James Capper, Peter James Tatnell, Jeffrey Kenneth Horton
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Publication number: 20170137874Abstract: Provided herein are methods and kits for isothermal nucleic acid amplifications that use a target nucleic acid template; a reaction mixture comprising a DNA polymerase having a strand displacement activity, a deoxyribonucleoside triphosphate (dNTP) mixture, a primer with a 3? end and a 5? end, a molecular crowding reagent, and a buffer solution for amplifying the target nucleic acid template. The buffer solution maintains a low salt concentration of the reaction mixture, and wherein the salt concentration results in a melting temperature (Tm) of the primer at least 10° C. below the reaction temperature. The amplification is effected under isothermal condition.Type: ApplicationFiled: January 30, 2017Publication date: May 18, 2017Inventors: Ryan Charles Heller, John Richard Nelson, Paresh Lakhubhai Patel, Alison Myfanwy Wakefield, Stephen James Capper, Peter James Tatnell, Jeffrey Kenneth Horton
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Publication number: 20170121747Abstract: Provided herein are methods and kits for isothermal nucleic acid amplifications that use a target nucleic acid template; a reaction mixture comprising a DNA polymerase having a strand displacement activity, a deoxyribonucleoside triphosphate (dNTP) mixture, a primer with a 3? end and a 5? end, a molecular crowding reagent, and a buffer solution for amplifying the target nucleic acid template. The buffer solution maintains a low salt concentration of the reaction mixture, and wherein the salt concentration results in a melting temperature (Tm) of the primer at least 10° C. below the reaction temperature. The amplification is effected under isothermal condition.Type: ApplicationFiled: January 18, 2017Publication date: May 4, 2017Inventors: Ryan Charles Heller, John Richard Nelson, Paresh Lakhubhai Patel, Alison Myfanwy Wakefield, Stephen James Capper
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Patent number: 9587263Abstract: Provided herein are methods and kits for isothermal nucleic acid amplifications that use a target nucleic acid template; a reaction mixture comprising a DNA polymerase having a strand displacement activity, a deoxyribonucleoside triphosphate (dNTP) mixture, a primer with a 3? end and a 5? end, a molecular crowding reagent, and a buffer solution for amplifying the target nucleic acid template. The buffer solution maintains a low salt concentration of the reaction mixture, and wherein the salt concentration results in a melting temperature (Tm) of the primer at least 10° C. below the reaction temperature. The amplification is effected under isothermal condition.Type: GrantFiled: March 26, 2014Date of Patent: March 7, 2017Assignee: General Electric CompanyInventors: Ryan Charles Heller, John Richard Nelson, Paresh Lakhubhai Patel, Alison Myfanwy Wakefield, Stephen James Capper
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Publication number: 20150275282Abstract: Provided herein are methods and kits for isothermal nucleic acid amplifications that use a target nucleic acid template; a reaction mixture comprising a DNA polymerase having a strand displacement activity, a deoxyribonucleoside triphosphate (dNTP) mixture, a primer with a 3? end and a 5? end, a molecular crowding reagent, and a buffer solution for amplifying the target nucleic acid template. The buffer solution maintains a low salt concentration of the reaction mixture, and wherein the salt concentration results in a melting temperature (Tm) of the primer at least 10° C. below the reaction temperature. The amplification is effected under isothermal condition.Type: ApplicationFiled: March 26, 2014Publication date: October 1, 2015Applicant: General Electric CompanyInventors: Ryan Charles Heller, John Richard Nelson, Paresh Lakhubhai Patel, Alison Myfanwy Wakefield, Stephen James Capper
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Publication number: 20050101693Abstract: Articles of apparel for an amputee's residuum and for non-amputees who desire or require padding or joint support.Type: ApplicationFiled: November 6, 2003Publication date: May 12, 2005Applicant: OHIO WILLOW WOOD COMPANYInventors: Robert Arbogast, James Capper, James Colvin, Jeffrey Doddroe, Bruce Kania, Christopher Kelley
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Publication number: 20050038525Abstract: A low profile prosthetic foot designed for use with a prosthetic ankle. The prosthetic foot includes at least one toe spring and at least one heel spring. The prosthetic foot is able to absorb shocks generated during ambulation of a user of said foot. When a prosthetic ankle is attached to the prosthetic foot, the position (height) of the ankle preferably approximates the position (height) of a typical human ankle.Type: ApplicationFiled: June 15, 2004Publication date: February 17, 2005Applicant: The Ohio Willow Wood CompanyInventors: Jeffrey Doddroe, Robert Arbogast, James Colvin, James Capper
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Publication number: 20050015157Abstract: A multi-axis prosthetic ankle for connection of a prosthetic lower leg to a prosthetic foot. In one embodiment, a prosthetic foot connection component is connected to a prosthetic lower leg connection component only by means of an elastomeric material, thereby allowing for multi-axis movement of the ankle without requiring direct contact between the two components. In other embodiments of the ankle, a prosthetic foot connection component may be mechanically connected to a prosthetic lower leg connection component. However, the design of the mechanical connection and the use of an elastomeric material casing allows for movement of the ankle without surface-to-surface sliding contact between the two components. Compression of the elastomeric material, as well as one or more mechanical stops may be used to control and limit movement of the ankle.Type: ApplicationFiled: February 3, 2004Publication date: January 20, 2005Applicant: The Ohio Willow WoodInventors: Jeffrey Doddroe, Robert Arbogast, James Colvin, James Capper