Abstract: The present disclosure relates to mTOR inhibitors. Specifically, the embodiments are directed to compounds and compositions inhibiting mTOR, methods of treating diseases mediated by mTOR, and methods of synthesizing these compounds.

Abstract: A sensing valve repair system includes a delivery system and a heart valve repair device. The delivery system is configured to deploy the heart valve repair device. The sensing valve repair system has a first sensor associated with one or more of the delivery system and the valve repair device. The first sensor is attached to one or more of an inner paddle and a fixed arm of a clasp.

Abstract: A series of substituted imidazo[1,2-b]pyridazine derivatives as defined herein, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

Abstract: Disclosed herein are integrated circuit (IC) supports with microstrips, and related embodiments. For example, an IC support may include a plurality of microstrips and a plurality of conductive segments. Individual ones of the conductive segments may be at least partially over at least two microstrips, a dielectric material may be between the plurality of microstrips and the plurality of conductive segments, and the conductive segments are included in a tape.

Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells wherein the CAR T cells comprise a CAR and the CAR comprises an E2 anti-fluorescein antibody fragment, and administering to the patient a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.

Abstract: Components for valve treatment systems are disclosed. Valve treatment systems can include a delivery system for an implantable device. The delivery system can include one or more of clasp control components slidably disposed on a catheter handle, a control element for opening and closing the implantable device, a catheter assembly with features to reduce friction with another catheter assembly, grips for attaching catheter assemblies to clamps, catheter assemblies with features that stiffen or provide variable stiffness, and catheter assemblies with one or more steering control lumens incorporated into a reinforcement layer.

Abstract: A child-resistant container may include an inner tray including a first side, a second side opposite the first side, a first locking mechanism on the first side, and a second locking mechanism on the second side; and an outer sleeve including a first sleeve side, a second sleeve side opposite the first sleeve side, a first locking port on the first sleeve side, a second locking port on the second sleeve side, an open end, and one or more catches. The inner tray may be slidably inserted into the outer sleeve through the open end such that each of the locking mechanisms releasably engages at least one of the locking ports. At least one of the locking mechanisms may engage with the one or more catches to prevent the inner tray from being fully withdrawn from the outer sleeve.

Abstract: A container is disclosed that includes an outer shell with an opening. A receptacle can be insertable through the opening of the outer shell, the receptacle configured to receive contents of the container. A flexible substrate can be releasably sealed to the receptacle. The flexible substrate can include a first edge, a second edge opposite the first edge, and one or more anchors positioned on or adjacent the second edge.

Abstract: Various embodiments are directed to a system for accessing a self-encrypting drive (SED) based on a blind challenge authentication response mechanism (BCRAM). An SED may be authenticated within a system, for example, upon resuming from a sleep state, based on a challenge generated within the SED, signed using a private key by a trusted execution environment (TEE) and authenticated using a corresponding public key within the SED.

Abstract: One aspect of the invention provides a system for radiation treatment of a tumor allowing for imaging of the tumor and a surrounding region during radiation therapy and to methods of using such a system. In one embodiment, the system includes a number of radiation detectors positioned in an array to detect radiation scattered from the tumor and the surrounding region. A 3-dimensional image of the tumor is reconstructed from the 2-dimensional scattered radiation projections.

Abstract: The present application relates to a control surface for an aircraft. The control surface has a leading edge, a trailing edge, and a chord-line defined between the leading edge and the trailing edge. A first aerodynamic surface is between the leading and trailing edges and a second surface is between the leading and trailing edges. The leading edge is formed by a nose, the nose having a hinge axis about which the control surface is deflectable. A maximum thickness of the control surface perpendicular to the chord-line between the first aerodynamic surface and the second surface is located aft of the hinge axis. The present application also relates to a control surface for an aircraft having a maximum curvature of the first aerodynamic surface of the control surface located aft of the hinge axis. The present application also relates to an aircraft or part of an aircraft comprising a fixed section and a control surface.

Abstract: A system for verifying the secure erase of a storage device is provided. A storage device controller for the storage device logs the execution of a secure erase command. A storage device controller for the storage device receives an erase verify command from a host. The storage device controller retrieves one or more secure erase log entries from access-limited memory locations in non-volatile memory of the storage device. The storage device controller copies the one or more secure erase log entries to storage device buffer circuitry. The storage device controller secures the one or more secure erase log entries with one or more cryptographic keys to generate an encrypted and/or signed erase verification message. The storage device controller transmits the encrypted and/or signed erase verification message to the host, in response to receipt of the erase verify command.

Abstract: Various embodiments are directed to a system for accessing a self-encrypting drive (SED) based on a blind challenge authentication response mechanism (BCRAM). An SED may be authenticated within a system, for example, upon resuming from a sleep state, based on a challenge generated within the SED, signed using a private key by a trusted execution environment (TEE) and authenticated using a corresponding public key within the SED.

Abstract: One aspect of the invention provides a system for radiation treatment of a tumor allowing for imaging of the tumor and a surrounding region during radiation therapy and to methods of using such a system. In one embodiment, the system includes a number of radiation detectors positioned in an array to detect radiation scattered from the tumor and the surrounding region. A 3-dimensional image of the tumor is reconstructed from the 2-dimensional scattered radiation projections.

Abstract: Various embodiments are directed to a system for accessing a self-encrypting drive (SED) based on a blind challenge authentication response mechanism (BCRAM). An SED may be authenticated within a system, for example, upon resuming from a sleep state, based on a challenge generated within the SED, signed using a private key by a trusted execution environment (TEE) and authenticated using a corresponding public key within the SED.

Abstract: The present application relates to a control surface for an aircraft. The control surface has a leading edge, a trailing edge, and a chord-line defined between the leading edge and the trailing edge. A first aerodynamic surface is between the leading and trailing edges and a second surface is between the leading and trailing edges. The leading edge is formed by a nose, the nose having a hinge axis about which the control surface is deflectable. A maximum thickness of the control surface perpendicular to the chord-line between the first aerodynamic surface and the second surface is located aft of the hinge axis. The present application also relates to a control surface for an aircraft having a maximum curvature of the first aerodynamic surface of the control surface located aft of the hinge axis. The present application also relates to an aircraft or part of an aircraft comprising a fixed section and a control surface.

Abstract: Various embodiments are directed to a system for accessing a self-encrypting drive (SED) based on a blind challenge authentication response mechanism (BCRAM). An SED may be authenticated within a system, for example, upon resuming from a sleep state, based on a challenge generated within the SED, signed using a private key by a trusted execution environment (TEE) and authenticated using a corresponding public key within the SED.

Abstract: A method of generating a time managed challenge-response test is presented. The method identifies a geometric shape having a volume and generates an entry object of the time managed challenge-response test. The entry object is overlaid onto the geometric shape, such that the entry object is distributed over a surface of the geometric shape, and a portion of the entry object is hidden at any point in time. The geometric shape is rotated, which reveals the portion of the entry object that is hidden. A display region on a display is identified for rendering the geometric shape and the geometric shape is presented in the display region of the display.

Abstract: A method of generating a time managed challenge-response test is presented. The method identifies a geometric shape having a volume and generates an entry object of the time managed challenge-response test. The entry object is overlaid onto the geometric shape, such that the entry object is distributed over a surface of the geometric shape, and a portion of the entry object is hidden at any point in time. The geometric shape is rotated, which reveals the portion of the entry object that is hidden. A display region on a display is identified for rendering the geometric shape and the geometric shape is presented in the display region of the display.