Abstract: A system includes a built hydraulic fracturing system with a plurality of devices connected together and a simulation of the built hydraulic fracturing system on a software application. Additionally, a fracturing plan may be provided on the software application to include pre-made instructions to perform multiple processes in a hydraulic fracturing operation such as a sequence of valve operations to direct fluid flow through a selected path. Further, the fracturing plan may be modified to create a customized fracturing plan including the pre-made instructions and at least one modified instruction. Furthermore, the customized fracturing plan may be executed to perform at least one of the processes in the built hydraulic fracturing system.

Abstract: A pipe assembly includes a flexible pipe segment and at least one end fitting. The at least one end fitting includes an end casing coupled to the flexible pipe segment and a seal housing removably coupled to the end casing. The end casing defines a seal housing-receiving bore extending longitudinally through the end casing, and the seal housing is positioned within the seal housing-receiving bore. The seal housing defines at least one seal bore extending from an axially distal surface of the seal housing, and one or more sealing elements are seated in a respective one of the at least one seal bore. The end casing is couplable to a counterpart fitting, and the seal housing and/or the one or more sealing elements are configured to define a sealing interface with the counterpart fitting.

Abstract: In some examples, a fluid ejection die includes a plurality of nozzles arranged in a plurality of nozzle columns, the plurality of nozzle columns distributed across a width of the fluid ejection die in a staggered manner, wherein nozzles of each respective nozzle column of the plurality of nozzle columns are spaced apart along a length of the fluid ejection die, wherein the plurality of nozzle columns includes a first pair of neighboring nozzle columns that are spaced by a first distance across the width. The plurality of nozzle columns includes a second pair of neighboring nozzle columns that are spaced by a second distance across the width, the second distance being larger than the first distance.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: Approaches for monitoring and managing one or more operational components of a data center are provided. Data for one or more applications associated with operational functionalities may be received. The one or more applications may be associated with one or more related applications. A failure of one or more components monitored by the one or more applications or the one or more related applications can be detected. A cause of the failure can be determined based, at least in part, upon detected changes and contextual information associated with the failure. At least one change can be made to the components based on the determined cause.

Abstract: The presently disclosed subject matter relates to isolated compositions and methods for treating and/or preventing sepsis and inflammatory conditions, such as Acute Respiratory Distress Syndrome (ARDS). In some embodiments, the presently disclosed subject matter relates to endothelial progenitor cell-derived exosomes to treat and/or prevent sepsis and inflammatory conditions, such as Acute Respiratory Distress Syndrome (ARDS). The endothelial progenitor cell-derived exosomes can be modified to overexpress one or more miRNAs.

Abstract: A pipe deployment system includes a vehicle, a deployment tool having a body with a spool engagement slot and a hydraulic motor mounted to the body, a spool having a pin extending along a rotational axis of the spool from an end of the spool, and an engagement spline rotationally engaging the hydraulic motor with the pin. The deployment tool is removably connected to the vehicle.

Abstract: Methods of sealing tubulars are disclosed herein, which methods may include: providing a patch plug assembly that includes: a shaft; a wedge coupled to the shaft; a slip coupled to the shaft; a plug slidably coupled to the wedge; and a ferrule disposed between the wedge and the plug; pushing the slip against the tubular; pushing the plug against the ferrule after the slip is pushed against the tubular; pushing the ferrule against the wedge after the plug is pushed against the ferrule; and pushing a plug portion of the plug against an inner surface of the tubular.

Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Abstract: Provided herein are compounds of the Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X1, X2, X3, X4, Ring D, and E have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Abstract: A wireless power transmitter includes a charging coil, an electronics housing, and a top side. The charging coil housing houses a charging coil and includes a top surface, wherein the charging coil wirelessly transmits power to a receiver placed on the top surface of the charging coil housing. The electronics housing houses one or more electronics and a fan. The top side is located adjacent to the electronics housing, wherein a top surface of the top side faces a bottom surface of the receiver. An intake cooling path is defined by a region between the bottom surface of the receiver and the top surface of the top side and an exhaust cooling path is located on a side of the charging coil housing opposite the intake cooling path and defined by a region between the receiver and the top surface of the top side.

Abstract: A diverter valve which includes a valve body, an inlet, a plurality of outlets, an internal cavity to which the inlet and the outlets are connected, and a valve member which is movably positioned in the cavity. The valve member includes a through bore which is configured to connect the inlet with a corresponding one of the outlets for each of a plurality of operative positions of the valve member. In operation of the diverter valve, the valve member is movable between its operative positions to selectively connect the inlet with any one of the outlets.

Abstract: An illustrative modular manifold system includes, among other things, two or more modular pump manifolds, a low-pressure header, and a main high-pressure manifold. Modular pump manifolds may include a low-pressure manifold for supplying fracturing fluid or water to pumps, a high-pressure manifold for supplying fracturing fluid or water to one or more wells and a bleed-off/prime-up manifold. Each modular pump manifold of the modular manifold system is configured to be fluidly isolatable from the other modular pump manifolds. Each isolated modular pump manifold is configured to be flushed with water, bled off and primed up independently of the other modular pump manifolds. After the bleed off, maintenance procedures may be performed on pumps associated with the isolated modular pump manifold. The modular pump manifolds that are not isolated may continue in active fracing stage operations while a modular pump manifold is isolated.

Abstract: An integrated cinema amplifier comprises a power supply stage that distributes power over a plurality of channels for rendering immersive audio content in a surround sound listening environment. The amplifier automatically detects maximum and net power availability and requirements based on audio content by decoding audio metadata and dynamically adjusts gains to each channel or sets of channels based on content and operational/environmental conditions. A power supply stage provides power to drive a plurality of channels corresponding to speaker feeds to a plurality of speakers. The amplifier has a front panel having an LED array with each LED associated with a respective channel or group of channels of the multi-channel amplifier, and a control unit configured to light the LEDs according to display patterns based on operating status or error conditions of the amplifier.

Abstract: An electronics module is configured to provide power to one of a plurality of different types of coil modules utilized for wireless charging. The electronics module includes an input power interface configured to receive direct current (DC) power, a DC-to-AC converter circuity configured to convert the DC power to alternating current (AC) power, and an output power interface having a first set of output pins and at least a second set of output pins configured to interface with each of the plurality of different types of coil modules, wherein AC power is selectively provided to the first set of output pins, or both the first and second set of output pins based on a type of coil module connected to the electronics module.

Abstract: A helmet includes an impact mitigating structure (100). The impact mitigating structure includes a first inner layer (102), a second outer layer (104) and a reactive layer (105) positioned between the first inner layer and the second outer layer. The reactive layer includes multiple elements (106) held between the first inner layer and second outer layer. The reactive layer is arranged such that, when the second layer is subject to an impact, the multiple elements of the reactive layer are configured to roll to facilitate movement of the first inner layer and the second outer layer with respect to each other.

Abstract: The present invention relates to a helmet comprising an impact mitigating structure, the impact mitigating structure comprising: a first layer; and a second layer; wherein one or more of a material property, a mechanical property and a geometrical property of the impact mitigating structure is arranged to, when the impact mitigating structure is subject to an impact, facilitate at least partial fracturing of the second layer such that at least a portion of the second layer is able to move relative to the first layer.

Abstract: Example implementations include a system and method for providing a graphical user interface (GUI) on a display, wherein the GUI is operable for displaying a representation of a detection field of an object counting radar unit, wherein the GUI is operable for displaying a reference point that represents a rotatable object as detected by the object counting radar unit when the rotatable object is located in a field-of-view of the object counting radar unit and is rotated by a drive motor assembly.

Abstract: A wireless power transmitter includes a charging coil, an electronics housing, and a top side. The charging coil housing houses a charging coil and includes a top surface, wherein the charging coil wirelessly transmits power to a receiver placed on the top surface of the charging coil housing. The electronics housing houses one or more electronics and a fan. The top side is located adjacent to the electronics housing, wherein a top surface of the top side faces a bottom surface of the receiver. An intake cooling path is defined by a region between the bottom surface of the receiver and the top surface of the top side and an exhaust cooling path is located on a side of the charging coil housing opposite the intake cooling path and defined by a region between the receiver and the top surface of the top side.