Abstract: A portable holder for use with standard top-opening tissue boxes fitted with a disposable waste receptacle bag to receive soiled tissues. The holder is made from a single foldable paperboard blank, cut and scored in such manner as to be quickly assembled around the tissue box and affixed to it by means of a notched flap. A small kitchen plastic bag or paper lunch bag may be used as the waste receptable and is disposed of with the soiled tissues. The holder can contain a printed design on one side in the form of a clown, animal or other familiar figure whereby the opening for the mouth is the site of the waste receptacle and the arms encircle the tissue box. The illustration may also be of a familiar object, setting or an abstract design. The unique fold system maintains the printed design on the outside surface of the assembled holder.