Abstract: This disclosure relates to JAK1 pathway inhibitors and their use in treating vitiligo.

Abstract: A vehicle wheel weight has a mass portion of nonlead material having a first side for juxtaposition against a wheel rim and an opposite second side, one of which defines a clip groove. The weight further includes a clip having an extended portion for engaging the wheel rim. The clip further has an attachment portion seated in the clip groove such that the clip is fixed to the mass portion. In this regard, the clip groove has an attachment member receiving hole defined therein. The attachment portion of the clip defines at least one securement hole in register with the attachment member receiving hole of the mass portion when the attachment portion of the clip is positioned in the clip groove. An attachment member extends through the securement hole and into the attachment member receiving hole such that the clip is fixed to the mass portion.

Abstract: A vehicle wheel weight has a mass portion of nonlead material having a first side for juxtaposition against a wheel rim and an opposite second side, one of which defines a clip groove. The weight further includes a clip having an extended portion for engaging the wheel rim. The clip further has an attachment portion seated in the clip groove such that the clip is fixed to the mass portion. In this regard, the clip groove has an attachment member receiving hole defined therein. The attachment portion of the clip defines at least one securement hole in register with the attachment member receiving hole of the mass portion when the attachment portion of the clip is positioned in the clip groove. An attachment member extends through the securement hole and into the attachment member receiving hole such that the clip is fixed to the mass portion.

Abstract: A method and apparatus is disclosed for determining the flow rate of drilling fluid flowing from a subaqueous well. The invention may also be used to determine the presence of an abnormal drilling condition during heaving motion of an offshore vessel from which the drilling operation is conducted. The invention measures the volume of fluid passing predetermined locations in the drilling system at particular points in time so as to eliminate the influence that the expansion and contraction of a telescoping section has on the total volume of drilling fluid within the system.

Abstract: An apparatus for limiting the tension to which a suspended member can be subjected is disclosed. The apparatus responds to excessive tensile stress by increasing in length at a rate to keep such stress from exceeding a predetermined level. The present invention includes a closed cylinder with a piston disposed therein. Connected to the piston is a piston rod which extends through an opening in one end of the cylinder. The cylinder and piston rod are adapted to connect with a suspended member and a hoisting means. A bypass conduit connects the cylinder chambers by extending from one side of the piston to the other. In the conduit, there is a flow control regulator which actuates when the pressure on one side of the piston reaches a predetermined level, corresponding to a proportional tensile stress, permitting fluid to flow through the conduit in such a volume that the pressure on that side of the piston is maintained at the predetermined level.