Patents by Inventor James D. Sterling
James D. Sterling has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11479747Abstract: Systems and methods for the efficient agitation of tissue samples. A device may include a plurality of chambers that each receives samples therein. The plurality of chambers may be uniformly spaced with respect to a least one dimension, to form a one dimensional or two dimensional array. Each of the chambers may include an opening and an agitator device in fluid contact with the sample disposed within the chamber. The agitator devices may include a micromotor which provides rotational motion to a shaft and an impeller fixed to the shaft such that the impeller and the shaft rotate together upon provision of the rotational motion by the micromotor. The system may include an electrical energy source electrically coupled to the plurality of micromotors to rotate the impellers sufficient to agitate the sample as required for a particular activity (e.g., homogenization, lysis).Type: GrantFiled: February 1, 2018Date of Patent: October 25, 2022Assignee: CLAREMONT BIOSOLUTIONS LLCInventors: Robert W. Doebler, Mark Brown, Tanya Ferguson, Bruce Irvine, James D. Sterling
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Patent number: 11473049Abstract: Oscillating angularly rotating a container containing a material may cause the material to be separate. Denser or heavier material may unexpectedly tend to collected relatively close to the axis of rotation, while less dense or light material may tend to collect relatively away from the axis of rotation. Oscillation along an arcuate path provides high lysing efficiency. Alternatively, a micromotor may drive an impeller removably received in a container. Lysing may be implemented in batch mode, flow-through stop or semi-batch mode, or flow-through continuous mode. Lysing particulate material may exceed material to be lysed or lysed material and/or air may be essentially eliminated from a chamber to increase lysing efficiency.Type: GrantFiled: September 9, 2019Date of Patent: October 18, 2022Assignee: CLAREMONT BIOSOLUTIONS, LLCInventors: Robert Doebler, Ali Nadim, James D. Sterling, Anna Hickerson, Barbara Erwin, Denice Woyski, Ryan P. Talbot, Bruce Irvine
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Publication number: 20200010789Abstract: Systems and methods for the efficient agitation of tissue samples. A device may include a plurality of chambers that each receives samples therein. The plurality of chambers may be uniformly spaced with respect to a least one dimension, to form a one dimensional or two dimensional array. Each of the chambers may include an opening and an agitator device in fluid contact with the sample disposed within the chamber. The agitator devices may include a micromotor which provides rotational motion to a shaft and an impeller fixed to the shaft such that the impeller and the shaft rotate together upon provision of the rotational motion by the micromotor. The system may include an electrical energy source electrically coupled to the plurality of micromotors to rotate the impellers sufficient to agitate the sample as required for a particular activity (e.g., homogenization, lysis).Type: ApplicationFiled: February 1, 2018Publication date: January 9, 2020Inventors: Robert W. Doebler, Mark Brown, Tanya Ferguson, Bruce Irvine, James D. Sterling
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Publication number: 20200002663Abstract: Oscillating angularly rotating a container containing a material may cause the material to be separate. Denser or heavier material may unexpectedly tend to collected relatively close to the axis of rotation, while less dense or light material may tend to collect relatively away from the axis of rotation. Oscillation along an arcuate path provides high lysing efficiency. Alternatively, a micromotor may drive an impeller removably received in a container. Lysing may be implemented in batch mode, flow-through stop or semi-batch mode, or flow-through continuous mode. Lysing particulate material may exceed material to be lysed or lysed material and/or air may be essentially eliminated from a chamber to increase lysing efficiency.Type: ApplicationFiled: September 9, 2019Publication date: January 2, 2020Inventors: Robert Doebler, Ali Nadim, James D. Sterling, Anna Hickerson, Barbara Erwin, Denice Woyski, Ryan P. Talbot, Bruce Irvine
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Patent number: 10428301Abstract: Oscillating angularly rotating a container containing a material may cause the material to be separate. Denser or heavier material may unexpectedly tend to collected relatively close to the axis of rotation, while less dense or light material may tend to collect relatively away from the axis of rotation. Oscillation along an arcuate path provides high lysing efficiency. Alternatively, a micromotor may drive an impeller removably received in a container. Lysing may be implemented in batch mode, flow-through stop or semi-batch mode, or flow-through continuous mode. Lysing particulate material may exceed material to be lysed or lysed material and/or air may be essentially eliminated from a chamber to increase lysing efficiency.Type: GrantFiled: October 20, 2016Date of Patent: October 1, 2019Assignee: Keck Graduate InstituteInventors: Robert Doebler, Ali Nadim, James D. Sterling, Anna Hickerson, Barbara Erwin, Denice Woyski, Ryan P. Talbot, Bruce Irvine
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Publication number: 20170037359Abstract: Oscillating angularly rotating a container containing a material may cause the material to be separate. Denser or heavier material may unexpectedly tend to collected relatively close to the axis of rotation, while less dense or light material may tend to collect relatively away from the axis of rotation. Oscillation along an arcuate path provides high lysing efficiency. Alternatively, a micromotor may drive an impeller removably received in a container. Lysing may be implemented in batch mode, flow-through stop or semi-batch mode, or flow-through continuous mode. Lysing particulate material may exceed material to be lysed or lysed material and/or air may be essentially eliminated from a chamber to increase lysing efficiency.Type: ApplicationFiled: October 20, 2016Publication date: February 9, 2017Inventors: Robert Doebler, Ali Nadim, James D. Sterling, Anna Hickerson, Barbara Erwin, Denice Woyski, Ryan P. Talbot, Bruce Irvine
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Patent number: 9358540Abstract: An isothermal reaction and analysis system may include a receiver to receive sample holders, a thermal control subsystem to control a temperature of the receiver, an excitation subsystem, a detection subsystem and an analysis subsystem. Excitation sources and/or detectors are positioned to enhance data collection. Sample holders may include filters, selectively blocking and passing wavelengths or bands of electromagnetic radiation.Type: GrantFiled: July 22, 2015Date of Patent: June 7, 2016Assignee: KECK GRADUATE INSTITUTEInventors: Robert W. Doebler, II, Christopher Cooney, Anna Hickerson, James D. Sterling, Ali Nadim
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Publication number: 20160151785Abstract: An isothermal reaction and analysis system may include a receiver to receive sample holders, a thermal control subsystem to control a temperature of the receiver, an excitation subsystem, a detection subsystem and an analysis subsystem. Excitation sources and/or detectors are positioned to enhance data collection. Sample holders may include filters, selectively blocking and passing wavelengths or bands of electromagnetic radiation.Type: ApplicationFiled: July 22, 2015Publication date: June 2, 2016Inventors: Robert W. Doebler, II, Christopher Cooney, Anna Hickerson, James D. Sterling, Ali Nadim
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Patent number: 9115393Abstract: An isothermal reaction and analysis system may include a receiver to receive sample holders, a thermal control subsystem to control a temperature of the receiver, an excitation subsystem, a detection subsystem and an analysis subsystem. Excitation sources and/or detectors are positioned to enhance data collection. Sample holders may include filters, selectively blocking and passing wavelengths or bands of electromagnetic radiation.Type: GrantFiled: June 17, 2014Date of Patent: August 25, 2015Assignee: Keck Graduate InsituteInventors: Robert W. Doebler, II, Christopher Cooney, Anna Hickerson, James D. Sterling, Ali Nadim
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Publication number: 20150024480Abstract: Oscillating angularly rotating a container containing a material may cause the material to be separate. Denser or heavier material may unexpectedly tend to collected relatively close to the axis of rotation, while less dense or light material may tend to collect relatively away from the axis of rotation. Oscillation along an arcuate path provides high lysing efficiency. Alternatively, a micromotor may drive an impeller removably received in a container. Lysing may be implemented in batch mode, flow-through stop or semi-batch mode, or flow-through continuous mode. Lysing particulate material may exceed material to be lysed or lysed material and/or air may be essentially eliminated from a chamber to increase lysing efficiency.Type: ApplicationFiled: August 4, 2014Publication date: January 22, 2015Inventors: Robert Doebler, Ali Nadim, James D. Sterling, Anna Hickerson, Barbara Erwin, Denice Woyski, Ryan P. Talbot, Bruce Irvine
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Publication number: 20140295534Abstract: An isothermal reaction and analysis system may include a receiver to receive sample holders, a thermal control subsystem to control a temperature of the receiver, an excitation subsystem, a detection subsystem and an analysis subsystem. Excitation sources and/or detectors are positioned to enhance data collection. Sample holders may include filters, selectively blocking and passing wavelengths or bands of electromagnetic radiation.Type: ApplicationFiled: June 17, 2014Publication date: October 2, 2014Inventors: Robert W. Doebler, II, Christopher Cooney, Anna Hickerson, James D. Sterling, Ali Nadim
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Patent number: 8784736Abstract: An isothermal reaction and analysis system may include a receiver to receive sample holders, a thermal control subsystem to control a temperature of the receiver, an excitation subsystem, a detection subsystem and an analysis subsystem. Excitation sources and/or detectors are positioned to enhance data collection. Sample holders may include filters, selectively blocking and passing wavelengths or bands of electromagnetic radiation.Type: GrantFiled: March 8, 2012Date of Patent: July 22, 2014Assignee: Keck Graduate InstituteInventors: Robert W. Doebler, II, Christopher Cooney, Anna Hickerson, James D. Sterling, Ali Nadim
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Publication number: 20120171756Abstract: An isothermal reaction and analysis system may include a receiver to receive sample holders, a thermal control subsystem to control a temperature of the receiver, an excitation subsystem, a detection subsystem and an analysis subsystem. Excitation sources and/or detectors are positioned to enhance data collection. Sample holders may include filters, selectively blocking and passing wavelengths or bands of electromagnetic radiation.Type: ApplicationFiled: March 8, 2012Publication date: July 5, 2012Inventors: Robert W. Doebler, II, Christopher Cooney, Anna Hickerson, James D. Sterling, Ali Nadim
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Patent number: 8153064Abstract: An isothermal reaction and analysis system may include a receiver to receive sample holders, a thermal control subsystem to control a temperature of the receiver, an excitation subsystem, a detection subsystem and an analysis subsystem. Excitation sources and/or detectors are positioned to enhance data collection. Sample holders may include filters, selectively blocking and passing wavelengths or bands of electromagnetic radiation.Type: GrantFiled: March 21, 2008Date of Patent: April 10, 2012Inventors: Robert W. Doebler, II, Christopher Cooney, Anna Hickerson, James D. Sterling, Ali Nadim
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Publication number: 20100178697Abstract: Oscillating angularly rotating a container containing a material may cause the material to be separate. Denser or heavier material may unexpectedly tend to collected relatively close to the axis of rotation, while less dense or light material may tend to collect relatively away from the axis of rotation. Oscillation along an arcuate path provides high lysing efficiency. Alternatively, a micromotor may drive an impeller removably received in a container. Lysing may be implemented in batch mode, flow-through stop or semi-batch mode, or flow-through continuous mode. Lysing particulate material may exceed material to be lysed or lysed material and/or air may be essentially eliminated from a chamber to increase lysing efficiency.Type: ApplicationFiled: March 25, 2010Publication date: July 15, 2010Applicant: KECK GRADUATE INSTITUTEInventors: Robert Doebler, Ali Nadim, James D. Sterling, Anna Hickerson, Barbara Erwin, Denice Woyski, Ryan P. Talbot, Bruce Irvine
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Publication number: 20080229849Abstract: An isothermal reaction and analysis system may include a receiver to receive sample holders, a thermal control subsystem to control a temperature of the receiver, an excitation subsystem, a detection subsystem and an analysis subsystem. Excitation sources and/or detectors are positioned to enhance data collection. Sample holders may include filters, selectively blocking and passing wavelengths or bands of electromagnetic radiation.Type: ApplicationFiled: March 21, 2008Publication date: September 25, 2008Inventors: Robert W. Doebler, Christopher Cooney, Anna Hickerson, James D. Sterling, Ali Nadim
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Patent number: 7163612Abstract: An active matrix microfluidic platform employs thin film transistor active (“TFT”) matrix liquid crystal display technology to manipulate small samples of fluid for chemical, biochemical, or biological assays without moving parts, for example, using a two-dimensional matrix array of drive electrodes. The active matrix microfluidic platform may employ existing active matrix addressing schemes and/or commercial “off-the-shelf” animation software to program assay protocols. A feedback subsystem may determine an actual location of a fluid in the microfluidic structure, and provides location information to for display, for example, on an active matrix display, and/or to control movement of one or more fluid bodies in the microfluidic structure.Type: GrantFiled: November 26, 2002Date of Patent: January 16, 2007Assignee: Keck Graduate InstituteInventors: James D. Sterling, Chao-Yi Chen
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Publication number: 20040231987Abstract: An microfluidic platform employs a two-dimensional matrix array of drive electrodes and at least one ground line on a bottom substrate, eliminating the need for a top plate or cover, to allow easy access to the active surface of the microfluidic platform. The open microfluidic platform may, for example, allow the depositing of samples via an array of pipettes or other automated deliver systems, and/or the use of standard video equipment to focus on the active surface to track positions of fluid bodies. A user may move fluid bodies and perform operations in real time and/or create animation files for later execution using a pointing device and a display device such as a monitor.Type: ApplicationFiled: October 16, 2003Publication date: November 25, 2004Applicant: Keck Graduate InstituteInventors: James D. Sterling, Chao-Yi Chen, Ali Nadim
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Publication number: 20030164295Abstract: An active matrix microfluidic platform employs thin film transistor active (“TFT”) matrix liquid crystal display technology to manipulate small samples of fluid for chemical, biochemical, or biological assays without moving parts, for example, using a two-dimensional matrix array of drive electrodes. The active matrix microfluidic platform may employ existing active matrix addressing schemes and/or commercial “off-the-shelf” animation software to program assay protocols. A feedback subsystem may determine an actual location of a fluid in the microfluidic structure, and provides location information to for display, for example, on an active matrix display, and/or to control movement of one or more fluid bodies in the microfluidic structure.Type: ApplicationFiled: November 26, 2002Publication date: September 4, 2003Applicant: Keck Graduate InstituteInventor: James D. Sterling