Abstract: A catheter interface protection device can include a shield. The shield can include an open bottom, a transparent upper surface, sidewalls, and a cavity at least partially defined by the bottom, the upper surface, and the sidewalls. The device can include a vent. The device can include a clip, a tether, and a latch. A non-therapeutic method of protecting a catheter interface can include extending a catheter in the subject through a slot in a catheter interface protection device, wrapping the catheter at least partially around a clip of the catheter interface protection device, and securing a latch of the catheter interface protection device around the clip. A device for positioning a subject in a prone position can include a padded area including an opening configured to accommodate a catheter interface protection device.

Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: A seal cartridge for a centrifugal pump includes a housing that fits within a conventional stuffing box of the pump and has a cylindrical internal surface receiving the shaft. A pair of annular grooves are provided internally of the housing adjacent respectively opposite ends thereof. Each groove receives an O-ring that runs in contact with the sleeve when the shaft rotates. The sleeve, housing and O-rings define an annular chamber through which water is circulated to cool and lubricate the O-rings. The water is pressurized to cause the O-rings to deform and seal against the sleeve.

Abstract: A seal cartridge for a centrifugal pump includes a housing that fits within a conventional stuffing box of the pump and has a cylindrical internal surface receiving the shaft. A pair of annular grooves are provided internally of the housing adjacent respectively opposite ends thereof. Each groove receives an O-ring that runs in contact with the sleeve when the shaft rotates. The sleeve, housing and O-rings define an annular chamber through which water is circulated to cool and lubricate the O-rings. The water is pressurized to cause the O-rings to deform and seal against the sleeve.